Nephrogenic systemic fibrosis (NSF) is a new fibrotic skin disease entity that was first recognized in 1997 in 15 patients receiving hemodialysis. Early reports noted that NSF closely resembled scleromyxedema, but had a number of differentiating features. The entity was initially termed nephrogenic fibrosing dermopathy, and a case definition was established based on its characteristic clinical and histopathologic features. The name was later changed to NSF in view of the systemic nature of the disorder and recognition of the role circulating fibrocytes play in mediating NSF. Underlying renal impairment is a prerequisite for the diagnosis of NSF, and 90% of ... Read More
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