Reglan users blame depression, suicidal thoughts on heartburn drug

The prescription drug Reglan, also known by the generic metoclopramide, is taken by more than 2 million people to treat the symptoms of gastrointestinal problems such as severe heartburn, gastroesophageal reflux disease (GERD) and gastroparesis. Many people have become aware of the drug’s serious side effects, including the debilitating neurological disorder known as Tardive Dyskinesia in which the muscles move involuntarily. Reglan’s safety label now includes an FDA black box warning for the risk of the disorder. But another serious condition is being blamed on the medication – suicidal ideation.

“My life is unbearable because of Reglan, and if the side effects don’t end soon, I am afraid that I will eventually kill myself,” writes Jodi* on bulletin board. “I took Reglan for a month. I gradually began to lose interest in things, couldn’t concentrate, and at the very end of the month became suicidal. It has now been a month since I have stopped taking Reglan, and every day is miserable and joyless. Everyday I cry and think about suicide. The side effects of this medication did not end when I stopped taking it.”

Bobby is also suspicious of Reglan. He wonders if his wife’s suicide was triggered by the drug. “My wife started taking Reglan last year, one week before she committed suicide at the age of 57,” he wrote on “She had never been diagnosed in her life as depressed.”

Reglan’s safety label carries a host of side effects, including the black box warning for Tardive Dyskinesia. Under the “important warnings” section, it also mentions side effects such as “depression” and “thinking about harming or killing yourself.” Perhaps its time for the FDA to issue another black box warning for its popular heartburn drug.