Heart attacks and strokes top the list of adverse reactions associated with testosterone replacement therapy, according to a report by openFDA and Truven Health Analytics. The report included all events linked to testosterone treatment regardless of whether the drug was thought to be the primary cause of the reaction.
There were 1,426 reports of myocardial infarction, or heart attack, followed by 1,005 reports of cerebrovascular accident, the medical term for strokes. Various blood clots were also high on the list of testosterone side effects with 910 cases of deep vein thrombosis (typically blood clots deep in the legs), 908 cases of pulmonary embolism (blood clot in the lungs), and 531 cases of thrombosis (blood clots).
The list also included 1,371 reports of pain and 828 injuries. Anxiety and emotional distress made the list with 924 and 630 cases, respectively. Economic problems rounded out the list with 933 cases.
The reports were gathered by openFDA, provider of APIs and raw download access to drug adverse event dataset, which receives data from the Food and Drug Administration (FDA) Adverse Event Reporting System, which contains information on adverse events and medication error reports submitted to the FDA. The information was provided by Truven Health Analytics, which delivers analytic tools, benchmarks, research and services to the health care industry.
Within the past two years, the FDA has strengthened or issued new warnings for testosterone replacement treatments involving increased risk for heart attacks and strokes, as well as a risk of mental health issues and dependency.
Source: Fox News