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acetaminophen 41 articles

Tylenol use during pregnancy linked to ADHD

Tylenol is often recommended to pregnant women to relieve pain and fever, but a new study suggests that pregnant women who take Tylenol and other medications containing acetaminophen long-term have a twofold increased risk of having a child with attention-deficit hyperactivity disorder (ADHD). Acetaminophen is available over-the-counter as well as by prescription in higher doses. An estimated 65 percent of pregnant women in the U.S. take the medication to relieve pain and fever. And while the medication is considered safe for pregnant women if taken short term, researchers with the Norwegian Institute of Public Health caution pregnant women against “continuous ... Read More

FDA recommends adding serious skin reactions warning to OTC acetaminophen

The Food and Drug Administration (FDA) is recommending that makers of over-the-counter acetaminophen-containing medicines add warning statements to the labels of their products informing consumers that use of acetaminophen has been associated with severe and potentially fatal skin reactions including Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). In 2013, after reviewing cases of serious skin reactions reported to the FDA’s Adverse Event Reporting System, the agency issued a drug safety communication alerting health care professionals and consumers of this risk. The recommendation isn’t binding, and the agency said it will not take legal action at this time if drug ... Read More

Long-term use of Advil, Tylenol linked to hearing loss

Using common over-the-counter pain relievers like Advil or Tylenol for an extended period of time may contribute to hearing loss, according to a study published in the American Journal of Epidemiology. Researchers examined data regarding use of aspirin, ibuprofen (Advil) and acetaminophen (Tylenol), as well as self-reported hearing loss, of more than 54,000 women between the ages of 48 and 73 enrolled in the Nurses’ Health Study. They found that longer duration of ibuprofen or acetaminophen use was tied to a greater risk of hearing loss. The increased risk was not seen with aspirin use. Longer duration was defined as ... Read More

Studies link prenatal exposure to Tylenol to increased risk of asthma, hyperactivity

Pregnant women have been lead to believe that the painkiller Tylenol (acetaminophen) is a safe for developing fetuses, but two new studies show that prenatal exposure to the widely used medicine can increase the risk of asthma or hyperactivity by the time that child reaches 7 years of age. The first study, published in the International Journal of Epidemiology, evaluated more than 53,000 children from the Norwegian Mother and Child Cohort Study for current asthma at ages 3 and 7. Researchers also noted maternal use of acetaminophen during pregnancy. They found that women who used the pain reliever while pregnant increased ... Read More

hyperactivity in children linked to acetaminophen use during pregnancy

Doctors are often leery of recommending prescription or over-the-counter medications to their pregnant patients because of concerns of causing harm to developing fetuses. But a new study published in JAMA Pediatrics has linked one common medicine that has long been given the green light for pregnant women to hyperactivity in their children. Acetaminophen is the active ingredient in Tylenol and various generic over-the-counter medicines, as well as some prescription painkillers. It is also found in medication for allergies, colds, flu and sleeplessness. It is considered safe for pregnant women, with more than half of women in the U.S. and Europe ... Read More

Plaintiffs gear up for Tylenol liver damage lawsuit

Plaintiffs suing Johnson & Johnson and its subsidiary McNeil-PPC Inc. in a multidistrict litigation (MDL) claiming the companies’ popular over-the-counter painkiller Tylenol caused liver damage, filed a motion to stop the defendants from testifying that their own family members have taken the medicine. The plaintiffs steering committee (PSC) argued that allowing such testimony would only prejudice juries. Plaintiffs cited a March 2014 ruling in a different lawsuit against Johnson & Johnson involving the OTC painkiller Motrin and the risk of a life-threatening allergic reaction known as Stevens Johnson Syndrome. In that case, a Louisiana federal court granted a plaintiff’s request ... Read More

Prolonged use of Tylenol during pregnancy linked to birth defects in male babies

Tylenol and other medicines containing acetaminophen have long been considered a safe painkiller for pregnant women, but a new study from the University of Edinburth has found that prolonged use of acetaminophen – also known as paracetamol – during pregnancy can drive down testosterone levels in those taking the medicine leading to reproductive disorders in male babies. Researchers gave laboratory mice three doses of acetaminophen every day for a week, and found that the mince given acetaminophen had a 45 percent reduction in testosterone compared to mice who were not given the medicine. Testosterone is produced in the testicles and serves ... Read More

Tylenol shown ineffective for back, arthritis pain relief

The popular over-the-counter painkiller Tylenol is no more effective as a placebo in treating back pain, knee or hip pain, or arthritis, according to a systematic review of randomized clinical trials. Tylenol contains the active drug ingredient acetaminophen, which is also available in various OTC brands as well as in greater doses and/or in combination with other drug ingredients in many prescription medications. The review, conducted by Australian researchers, involved three randomized trials that pitted the effects of acetaminophen against a placebo for spinal pain, and 10 trials evaluating the drug for relieving the pain of osteoarthritis. In total, the analysis ... Read More

First bellwether lawsuit alleging severe liver damage with Tylenol scheduled for June trial

The first bellwether case in a multidistrict litigation against Johnson & Johnson subsidiary McNeill alleging the company’s Tylenol products caused severe liver damage has been set for June 22. The lawsuit was filed by Rana Terry, administrator of her sister Denice Hayes’ estate, who claims her sister took Tylenol Extra Strength in August 2010, and followed the instructions on the medicine’s label. Later that month, Hayes went to the emergency room with severe liver damage and died a week later. Terry alleges that Johnson & Johnson and McNeill knew acetaminophen, the active ingredient in Tylenol, was unreasonably dangerous yet the ... Read More

Acetaminophen as effective as placebo in treating lower back pain

The commonly used painkiller acetaminophen, the same drug in over-the-counter Tylenol, doesn’t relieve lower-back pain any better than a placebo, according to a new study published in the journal The Lancet. Medical guidelines recommend acetaminophen as a first-line treatment for acute lower back pain, however few studies have been conducted to show whether the treatment actually works. Researchers with the University of Sydney in Australia set out to put the painkiller to the test. For the study, researchers randomly assigned more than 1,600 people with sudden, or acute, lower-back pain into three groups. One group took acetaminophen tablets regularly three ... Read More