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Actos 310 articles

Insulin use linked to cardiovascular events, cancer, death

Type 2 diabetics taking insulin to control their blood sugar levels may be at greater risk of major cardiovascular events, cancer and death, and those taking higher doses of insulin are at even greater risk, according to new research published in the journal Diabetes, Obesity and Metabolism. Researchers with the Cardiff University School of Medicine in the United Kingdom said the findings add to ongoing concerns about insulin use to treat the chronic disease, adding that more research was needed on the issue. The study involved 6,484 patients with type 2 diabetes who were using insulin from the year 2000. ... Read More

Using type 2 diabetes drug Actos a risk factor for bladder cancer

The American Cancer Society warns that long-term use of the type 2 diabetes drug Actos, known generically as pioglitazone, can increase the risk of bladder cancer. The bladder is a hollow organ in the pelvis with flexible, muscular walls designed to store urine before it leaves the body. There are four main layers to the bladder. The innermost lining is made up of cells called urothelial or transitional cells. The next layer, called the urothelium, is made of up a thin layer of connective tissue, blood vessels, and nerves. Next is a layer of muscle, and the outer layer is ... Read More

Type 2 diabetes can be prevented, reversed by following healthy lifestyle

Type 2 diabetes can be prevented or even reversed with simple lifestyle changes, according to Dr. Eberhard Standl, a diabetes expert and spokesman for the European Society of Cardiology (ESC). Type 2 diabetes has grown in epidemic proportions, with 400 million diabetics and another 400 million pre-diabetics around the world. The chronic disease contributes to serious health concerns including heart disease, kidney disease, dementia, amputations due to neuropathy, some forms of cancer, and blindness. The disease contributed to an estimated 5 million deaths in 2014 alone. Once known as adult-onset diabetes, type 2 diabetes now affects as many as 80,000 ... Read More

Top best-selling Type 2 diabetes drugs linked to cancer

Nearly half of the top-selling Type 2 diabetes drugs come from a class of drugs known as incretin mimetics. They have been linked to a painful inflammation of the pancreas called acute pancreatitis, and an increased risk of pancreatic cancer. The list, compiled by Genetic Engineering & Biotechnology News, ranks FDA-approved type 2 diabetes drugs based on sales for the year 2013. Drugs not included in the list include those whose sales figures were withheld, such as Johnson & Johnson’s Invokana (canagliflozin), as well as the several treatments approved during 2014, such as Boehringer Ingelheim’s Jardiance (empagliflozin), Eli Lilly’s Trulicity (dulaglutuide) ... Read More

FDA approves new type 2 diabetes treatment

The Food and Drug Administration (FDA) has approved Xigduo, a new once-daily treatment for type 2 diabetes. Xigduo is a combination of an extended release version of the long-used diabetes drug metformin and dapagliflozin, a diabetes drug recently approved by the FDA and marketed under the name Farxiga. Xigduo is the first and only once-daily combination oral medication of an SGLT2 inhibitor and an extended release version of metformin to be approved in the United States. The drug is intended to be used in combination with exercise and diet to improve glycemic control in adults with type 2 diabetes. The ... Read More

Patients with Type 2 diabetes should follow care routine, be aware of medication risks

Some people with Type 2 diabetes can manage their disease with diet and exercise, but for the millions who still experience spikes in blood sugar, it may be time to add medication to their diabetes care routine. For some, a single pill is effective. For many, however, a combination of medications is needed. It may take time finding a good balance but it is well worth the effort. Uncontrolled diabetes can lead to serious health issues including heart disease, kidney disease, dementia, blindness and amputations due to neuropathy. The most commonly prescribed type 2 diabetes medication is metformin, which belongs ... Read More

Diabetes drug Farxiga label updated to include new warnings for bladder cancer risk

The safety labels of the new type 2 diabetes drug Farxiga (dapagliflozin) have been updated to advise patients and health care professionals not to monitor glycemic control with urine glucose tests in patients taking Farxiga or similar drugs in the class because the drugs increase urinary glucose excretion and will lead to positive glucose tests. Alternative methods are advised to monitor glucose control. Farxiga was approved by the Food and Drug Administration (FDA) in January to help lower blood sugar levels in patients with type 2 diabetes. Manufactured by AstraZeneca and Bristol-Myers Squibb, Farxiga had been previously rejected because of ... Read More

UNC researchers investigate Drug Induced Liver Injuries in connection with diabetes drugs

When life-threatening side effects are linked to pharmaceuticals already on the market, it can lead to black box warnings or even market withdrawal. When this potential for injury is found during clinical trials before the medication has been approved, it can stop development in its tracks resulting in a waste of time and resources. “We’re trying to be smarter in our approach to drug development,” says Kim Brouwer, a researcher with the University of North Carolina. Brouwer and colleagues have partnered with the Drug Induced Liver Injury (DILI)-sim Initiative, a group of life science companies led by the Hamner Institutes ... Read More

Researchers work to develop diabetes drugs with fewer side effects

Researchers with the Department of Medicine at Imperial College London and LMU Munich in Germany are developing a type 2 diabetes drug that can be switched off and on with a blue light, potentially improving treatment. Many type 2 diabetes drugs encourage the pancreas to release insulin to control blood sugar levels, but they can also cause side effects to other organs. Other drugs encourage too much insulin release, causing blood sugar levels to drop to dangerously low levels. The prototype drug, called JB253, is designed to stimulate insulin release from pancreatic cells only when it is exposed to blue ... Read More

Researchers working on drug to cure type 2 diabetes

A modified form of the drug niclosamide , used to eradicate intestinal parasites, could help stop type 2 diabetes at its source, a team of researchers say. Type 2 diabetes is a chronic condition in which the body does not produce enough insulin to control blood sugar levels. This can lead to serious health consequences including heart disease, kidney disease, some types of cancer, blindness, amputations due to neuropathy, and Alzheimer’s disease. A major cause of insulin resistance is from the accumulation of excess fat in the cells of the liver and muscle tissue. The study involved finding a safe ... Read More