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Actos 310 articles

Cancer Monthly urges Actos users to be aware of the signs of bladder cancer

Cancer Monthly, an information site about the disease, is advising people who take or have taken the type 2 diabetes drug Actos to be aware of the symptoms of bladder cancer following a $9 billion judgment against the drug company to compensate a single bladder cancer victim. According to court testimony, the plaintiff took Actos for five years before he was diagnosed with bladder cancer in 2011. Also that year, the Food and Drug Administration (FDA) issued a warning that people who took Actos for a year were 40 percent more likely to develop bladder cancer. The FDA ordered Takeda ... Read More

Takeda hit with more sanctions in Actos bladder cancer trial

Takeda Pharmaceuticals was hit by sanctions for its defense counsel’s “very disrespectful” conduct during the trial of two women who claim the drug company’s type 2 diabetes medication Actos caused them to develop bladder cancer. The trial of Delores Cipriano and Bertha Triana began in February, however the court noted that “defense counsel has repeatedly engaged in disruptive and disrespectful behavior toward the court, which is well-documented in the record. As a result, the court’s decision to impose sanctions is based on the aforementioned cumulative conduct of counsel in disobeying court orders and disrupting court procedings.” Plaintiffs reported they had ... Read More

California study reveals one third of patients hospitalized have diabetes

Nearly a third of patients age 35 and older who were hospitalized in 2011 in California were diabetics, despite only 11.6 percent of people living in California having the chronic disease. Not all patients were hospitalized for diabetes. However, these patients are more susceptible to complications such as vascular or retinal disease. They also require special measures to keep their blood sugar levels in check. Diabetes is a growing concern. More than 90 percent of diabetics have type 2 diabetes, a condition often caused by obesity, poor eating habits, and a sedentary lifestyle. People with diabetes are at greater risk ... Read More

European Union approves new combination treatment for type 2 diabetes

European Union drug regulators have approved a new combination pill to treat type 2 diabetes. Vokanamet combines the new diabetes drug Invokana with the standard treatment metformin. The new treatment is made by Johnson & Johnson and will be marketed in Europe by Janssen-Cliag International. The active ingredient in Invokana is canagliflozin, which is in a class of diabetes medications known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. These drugs are designed to help reduce blood sugar levels by preventing the reabsorption of glucose from the kidneys back into the blood, and allows glucose to be excreted in the urine. The U.S. ... Read More

Number of children with type 1, type 2 diabetes has increased dramatically in recent years

The number of children diagnosed with type 1 or type 2 diabetes has increased dramatically in the past eight years, according to a new study published in the Journal of the American Medical Association. From 2001 to 2009, the number of children with type 1 diabetes increased by 21 percent and the number of children with type 2 diabetes rose 30.5 percent. The increase was similar among boys and girls as well as among racial groups. Researchers say the reason for the increase is still in question. Individuals with type 1 diabetes, once called juvenile diabetes because it is most ... Read More

Type 2 diabetes may shrink brain tissue, lead to cognitive disorders

Long-term type 2 diabetes may shrink gray matter, the portion of the brain responsible for memory, emotions, decision-making and self control, according to a new study published in the journal Radiology. For each decade a person has diabetes, his brain looks about two years older than a non-diabetic, researchers found. For the study, researchers with the University of Pennsylvania analyzed MRI scans to evaluate brain structure of more than 600 patients with type 2 diabetes. They were surprised to find that diabetes was not linked to just the damaging effect of the tiny blood vessels in the brain, but by ... Read More

Increased risk of death, cancer linked to very low blood sugar in type 2 diabetics

Type 2 diabetics with severe hypoglycemia, or very low blood sugar, are at an increased risk of death and of developing various cancers, a new study finds. Hypoglycemia can happen suddenly and if left untreated can worsen and cause confusion, clumsiness, or fainting. Severe hypoglycemia can lead to seizures, coma, and even death. Many medications to treat type 2 diabetes can cause very low blood sugar levels. For the study, researchers from Hong Kong studied 8,767 patients with a mean age of 57.4, and divided them into two groups – those with severe hypoglycemia and those without the condition. Both also had ... Read More

Alabama residents with Type 2 diabetes sought for long-term study on medication effectiveness

Researchers at the University of Alabama at Birmingham (UAB) are enrolling participants in an ongoing study on the long-term benefits and side effects with certain combinations of drugs to treat type 2 diabetes. Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness, or GRADE, is a national study that is being conducted at UAB and 36 other sites across the country. Enrollment began in June 2013, but more participants are being sought. More than 5,000 people will be enrolled in the study. Subjects must have type 2 diabetes that was diagnosed within the past five years and should not be on ... Read More

Participants sought to test long-term effects of popular type 2 diabetes drugs

Researchers at Washington University School of Medicine in St. Louis are seeking volunteers to participate in a study comparing the long-term risks and benefits of four widely prescribed diabetes drugs. The medications will be given in combination with the widely used metformin. The Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) study will span five years, during which time researchers will evaluate how the drugs affect blood sugar levels, diabetes complications and quality of life. Each drug’s side effects will also be noted. The research team also aims to examine individual factors associated with better or worse response to ... Read More

Cases of diabetes on the rise in the United States

The number of Americans with diabetes has nearly doubled in the past 20 years, paralleling the country’s growing obesity epidemic. Experts say if the trend continues, the number of Americans with diabetes will reach 44 million in the next 20 years. The study was published this week in the Annals of Internal Medicine. Researchers say the increase could be attributed to better screening tools, such as the hemoglobin A1c diagnostic test. However, researchers say the number of estimated undiagnosed cases in the past two decades has remained flat at about 2.3 million. Type 2 diabetes is by far the most ... Read More