Tagged Articles

adolescents 11 articles

Warnings of teen suicide risk with antidepressants may have led to increase in teen suicide attempts

Researchers are concerned that recent warnings about antidepressants increasing suicide risk in teens may have contributed to a rise in teen suicide attempts. The study, published in the British Medical Journal, set out to investigate this possible power of suggestion since 2003, when the Food and Drug Administration (FDA) began publicizing suicide risks (including suicide attempts and completed suicides) with antidepressant use in young adults. The study involved data from about 2.3 million adolescents and young adults. Researchers found that the warnings led to a significant drop in antidepressant use in young people, beginning in 2003. At the same time, ... Read More

North Carolina woman says prescription drug-induced psychosis led husband to kill daughters

The moment Kim Crespi of Charlotte, N.C., heard that her husband David had stabbed their 5-year-old twin daughters to death, she knew that the real culprit behind the horrific act wasn’t her spouse but a cocktail of prescription drugs, including Selective Serotonin Reuptake Inhibitors, or SSRIs – a form of antidepressants. According to Charlotte’s WBTV, David Crespi, a Charlotte-area banker, called 911 on the morning of Jan. 20, 2006 to report that he had just killed his own daughters. Mr. Crespi was arrested and ultimately took a plea bargain to avoid the death penalty. He is now serving two life ... Read More

Young people who start antidepressants at higher doses more prone to suicidal thoughts

Children and young adults who start taking antidepressants at higher than recommended doses are twice as likely to have suicidal thoughts or attempt suicide than those who begin treatment at lower doses, according to a new study published in JAMA Internal Medicine. For the study, researchers examined data from 1998 through 2010 on about 163,000 people ages 10 to 64 who were treated for depression. Some people in the study were given the recommended dosage, while others were started at higher doses. It was not made clear why some individuals started at higher-than-typical doses. About 18 percent of 10- to ... Read More

Risperdal makers marketed bipolar drug to children despite alarming side effects

In 1993, the Food and Drug Administration (FDA) approved the antipsychotic medication Risperdal (risperidone) to treat manic or mixed delusional episodes in adult patients with schizophrenia. Fourteen years later that the FDA expanded the indication to include children and adolescents, but only for the treatment of schizophrenia and bipolar disorder. Yet, between 1993 and 2008, Risperdal was being administered “off label” to thousands of children, many of whom suffered complications from the drug, including death. In fact, the FDA ordered Johnson & Johnson in 2001 to change the drug’s label stating that the safety and efficacy of Risperdal in children ... Read More

Anti-seizure drug Topamax approved for treatment of migraine headaches in teens

Federal drug regulators have approved the anti-seizure drug Topamax, known generically as topiramate, as a prophylaxis treatment for migraine headaches in teenagers ages 12 to 17. It is the first medication to be approved by the Food and Drug Administration (FDA) for adolescents. It is intended to be taken daily to prevent or reduce the frequency of migraines. Topamax first won FDA approval in 1996 to help prevent seizures. It was approved as a migraine prevention for adults in 2004. The expanded indication to include adolescents was based on a clinical trial involving 103 patients ages 12 to 17. Among ... Read More

Forest to pay millions to Missouri parents for misleading drug data on childhood depression meds

Forest Laboratories will pay between $7.7 million and $10.4 million to settle multidistrict litigation alleging the drug company misled Missouri parents into buying Celexa and Lexapro for their children even though the antidepressants were not approved for children. The class includes all parents and other third parties in Missouri who purchased Celexa for a minor patient between Jan. 1, 1998, and Dec. 31, 2013, or Lexapro for a child between Aug. 1, 2002, and Dec. 31, 2013. Forest is accused of covering up clinical trial data that showed Celexa was ineffective in treating pediatric depression based on studies from as ... Read More

Lawsuit alleges Forest mislead public about Celexa, Lexapro effectiveness in treating childhood depression

Forest Laboratories is facing a potential class action lawsuit in Massachusetts federal court by two funds that allege the company illegally marketed its antidepressants Celexa and Lexapro and paid kickbacks to others to endorse the drugs as a treatment for pediatric depression. The lawsuit, filed by Allied Services Division Welfare Fund and New Mexico UFCW Union’s and Employers’ Health and Welfare Trust Fund, allege they and others had to pay or provide reimbursement for Celexa and Lexapro. However, the lawsuit claims, the sales of those drugs were based on inadequate drug labels that were designed to mislead consumers and the ... Read More

Actos label updated to advise against use in pediatric patients with type 2 diabetes

The type 2 diabetes drug Actos is not recommended for children or adolescents because of potentially dangerous side effects including fluid retention and congestive heart failure, fractures and urinary bladder tumors, according to an update to the drug’s safety label. Actos, known generically as pioglitazone, is an oral diabetes medicine that helps control blood sugar levels. It is approved for use in adults with type 2 diabetes, a chronic condition often associated with obesity and a sedentary lifestyle. The condition was once known as “adult onset diabetes,” however, with increasing childhood obesity, more children and adolescents are being diagnosed with ... Read More

Bayer markets Mirena-like IUD for adolescents despite Mirena IUD injury lawsuits

A new intrauterine device is being marketed in the United States with sexually active adolescents in mind. Skyla, made by Bayer Healthcare, is raising concerns among some experts not because it is geared toward younger women, but because some IUDs, especially the Mirena, also made by Bayer, have been associated with injuries, some of which have been serious. Skyla is a new version of Bayer’s Mirena. Both deliver a steady dose of the hormone levonorgestrel, but Skyla is smaller than the Mirena, lasts up to three years as opposed to five years with Mirena, and contains less of the hormone ... Read More

Study finds Avandia-plus-metformin is best for young type 2 diabetics

A drug made of metformin and Avandia is better at controlling blood sugar levels in children and adolescents with type 2 diabetes than metformin alone, but the serious risks associated with Avandia raise concerns about the new drug combo. Avandia is a type 2 diabetes medication that was severely restricted by the Food and Drug Administration (FDA) in 2010 after the drug was linked to fatal heart attacks. Actos, another type 2 diabetes medication, is in the same class of medications and was recently linked to bladder cancer. The new study, called the Treatment Options for Type 2 Diabetes in Adolescents and ... Read More