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atorvastatin 19 articles

Mylan recalls 2.5M bottles of generic Lipitor due to possible contamination

Mylan Pharmaceuticals Inc., is recalling more than 2.5 million bottles of generic Lipitor, a cholesterol-lowering statin medication known chemically as atorvastatin, due to the potential for microbial contamination. The Food and Drug Administration (FDA) has listed the issue as a Class II recall, which involves a situation in which use of or exposure to a violative product may cause temporary or medically reversible health consequences or where the probability of serious adverse health consequences is remote. Affected products were distributed nationally. The recall includes atorvastatin calcium tablets packaged in 90-count or 500-count bottles and include more than 1.2 million 10mg ... Read More

Type 2 diabetes added to list of statin side effects

Cholesterol-lowering statin drugs are widely prescribed to lower levels of LDL – the so-called “bad” cholesterol – that builds up in the arteries in order to prevent cardiovascular events. However, studies have found the drugs can increase blood sugar levels and put users at risk of developing type 2 diabetes. Statins work by preventing the liver from producing LDL cholesterol. They also stabilize the lining of the blood vessels, which helps to prevent strokes and heart attacks. How statins effect glucose metabolism is unclear. Some studies suggest that statins may cause hyperglycemia – or high blood sugar – by increasing ... Read More

Pfizer faces thousands of lawsuits linking Lipitor to type 2 diabetes

From the time the cholesterol-lowering statin Lipitor (atorvastatin) hit the market in 1996, it has been the No. 1 best-selling prescription drug in the country, bringing in more than $130 billion in worldwide sales. More than 29 million people in the United States currently take the drug to control their cholesterol. However, this wonder drug comes with a price – an increased risk of type 2 diabetes. Now, thousands of former users have filed lawsuits against drug maker Pfizer alleging the company did not adequately warn users of this risk. In 2012, the Food and Drug Administration (FDA) issued a ... Read More

FDA rejects consumer group’s request for black box warning on statin drugs

Cholesterol-lowering statin medication will not carry a black box warning for a deadly muscle disorder, the Food and Drug Administration (FDA) announced. The agency was petitioned by the consumer watchdog group Public Citizen, urging the FDA to force drug makers to alert consumers of the risk of rhambdomyolysis, a condition in which muscle cells break down and enter the bloodstream where they can damage the kidneys. Public Citizen filed its petition in 2001, not long after Bayer pulled its statin drug Baycol (cerivastatin) off the market after mounting reports of patients dying from the condition while taking the medication. The ... Read More

UK advisors propose wider indication for cholesterol-lowering statins

The National Institute for Health and Care Excellence (NICE) has released a draft guidance on the management of high cholesterol for people with and without cardiovascular disease, as well as those with diabetes and chronic kidney disease. NICE, an agency that provides guidance for the United Kingdom’s National Health Service, recommends that high-intensity statin medications be given as a primary preventative treatment in patients with a 10 percent risk of cardiovascular disease over the next 10 years. Previously, the recommendation was for patients with a 20 percent risk of cardiovascular events over the next 10 years be treated with statins. ... Read More

Merck recalls all lots of new cholesterol pill Liptruzet

Drug company Merck & Co. is recalling its entire U.S. stock of the new combination cholesterol pill Liptruzet because of a packaging defect. The recall affects every batch from all four strength doses of the pill. Liptruzet was approved by the Food and Drug Administration (FDA) in May. It is a combination of the ezetimibe (the active ingredient in Zetia) and atorvastatin (the drug ingredient in the statin Lipitor). Liptruzet is designed to help block the absorption of cholesterol that comes from food, as well as reduce the cholesterol the body makes naturally based on family history. It can also ... Read More

Widely prescribed statins increase risk of type 2 diabetes

The cholesterol-lowering statin Crestor (rosuvastatin) is the top selling prescription medication for the 12-month period ending September 2013, according to a report from the research firm IMS Health. Crestor sold more than 23.7 million prescriptions raking in sales of $5.3 billion during that time period. Statins are commonly prescribed to lower cholesterol levels. They work by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produce about 70 percent of total cholesterol in the body. Increased cholesterol levels have been associated with cardiovascular disease. Thus, statins are used to help ... Read More

Cholesterol-lowering statin medications can interfere with exercise

Regular physical activity is great for the body – helping to control weight, boost good HDL cholesterol, improve mood and lower the risk of diabetes and some cancers. But even with good exercise and healthy diet, cholesterol levels can be higher than desired. Cholesterol-lowering statins, such as Lipitor (atorvastatin), are often given to people in order to improve cholesterol levels and protect against heart disease. However, statins can lead to side effects that can make physical activity difficult. A study published in the Journal of the American College of Cardiology showed that the statin Zocor (simvastatin) prevented exercisers from reaching ... Read More

Novel new cholesterol-lowering drug highly anticipated by analysts

A novel new oral medication by Esperion Therapeutics designed to lower cholesterol levels to help protect against heart disease is making its way through clinical trials, and analysts say it is a compound that should be taken seriously. The reason? Esperion founder Roger Newton was one of the key players in the development of Lipitor (atorvastatin), the widely used cholesterol-lowering statin medication made by Pfizer. Statins are commonly prescribed to patients with elevated cholesterol levels and have shown to be effective. However, they can carry potentially serious side effects including muscle pain leading to muscle injury as well as liver damage. ... Read More

Crestor ranks first, Lipitor ranks 73rd on list of most prescribed drugs in US

The cholesterol-lowering statin Crestor (rosuvastatin) was the most prescribed drug in the United States during a 12-month period with 23.7 million prescriptions, according to a new report from research firm IMS Health. The report looked at the top 100 selling drugs in the U.S. based on prescriptions and sales during a 12-month period ending last September 2013. The only other statins to make the list include Zetia (ezetimibe) which ranked 19th on the list, and Lipitor (atorvastatin), which ranked 73rd. Lipitor may have ranked low but it is still the best selling drug in the history of pharmaceuticals with more ... Read More