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atorvastatin 19 articles

Lipitor may protect against gum disease but increases blood sugar levels

A high dose of the widely prescribed cholesterol-lowering statin atorvastatin, known by the brand name Lipitor, may help alleviate periodontal disease, a small, randomized study suggests. However, other studies have shown Lipitor puts users at risk for type 2 diabetes, a condition that if not properly controlled can lead to gum disease. Periodontal disease is a gum disease that affects nearly half of U.S. adults. It has been associated with atherosclerosis, or hardening of the arteries in some studies although more recent studies have questioned the connection. The possible connection between atherosclerosis and gum disease comes from the type of ... Read More

Statins help lower stroke risk in diabetics, but can increase risk of diabetes in others

Cholesterol-lowering statin medications reduce the risk of recurrent stroke in patients who have diabetes or metabolic syndrome, a group of risk factors that occur together and increase the risk for coronary artery disease, stroke and type 2 diabetes, a new analysis indicates. The study, conducted by researchers at Vanderbilt University, is the first that focuses on the effect of statin treatment on secondary stroke prevention in people with type 2 diabetes or metabolic syndrome. The primary conclusion of the clinical trial found that the statin Lipitor (atorvastatin) reduced the risk of stroke in general. The secondary analysis assessed stroke risk ... Read More

Discontinuing use of cholesterol-lowering Lipitor linked to Parkinson’s disease

Cholesterol-lowering statins, which include the widely prescribed Lipitor, were once thought to be wonder drugs because of their ability to protect against cardiovascular disease. However, new studies have raised concerns about the safety of the drugs and whether they may put users at greater risk for other health problems. Recent studies have identified a possible link between the use of statin medications and the development of type 2 diabetes. The risk was greater with Lipitor compared to other statins. Data from a University of Massachusetts study also showed that postmenopausal women who took Lipitor, particularly those with a body mass ... Read More

Cholesterol-lowering drug Lipitor associated with risk of developing type 2 diabetes

Cholesterol-lowering drugs may increase the chances of developing type 2 diabetes, according to a large Canadian study. The risk is grater for patients taking Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). All three drugs are in a class of medications known as statins. They lower cholesterol by inhibiting the enzyme HMG-CoA reductace, which plays a central role in the production of cholesterol in the liver. Elevated cholesterol levels have been associated with cardiovascular diseases, and statins are used to help prevent these diseases. Statins have been effective in lowering cholesterol but they do carry adverse events, specifically muscle damage. The ... Read More

Statins tied to increased risk for type 2 diabetes

Statin drugs used to prevent heart attacks may increase the risk of type 2 diabetes, according to a new study published in the British Medical Journal. Statins are a class of drugs commonly prescribed to help lower “bad” cholesterol in the blood to reduce the chances of heart attack or stroke. The study, conducted by researchers in Canada, compared the incidence of diabetes between 1.5 million people older than age 66 taking various statins. They found that the strongest statins could increase the risk of type 2 diabetes by 22 percent compared to less potent drugs. Atorvastatin, known by the ... Read More

Merck seeks approval for previously rejected combination cholesterol drug

Merck & Co. is resubmitting the drug application for its combination cholesterol-lower drug MK-0653C, which was rejected by the Food and Drug Administration (FDA) last March due to insufficient data. The experimental medication combines a generic version of the cholesterol-lowering drug Lipitor, the top-selling medication of all time, with Merck’s cholesterol med Zetia. Lipitor and Zetia work in different ways to reduce high cholesterol and thus reduce the risk of heart attack and stroke. Lipitor, also known as atorvastatin, is a member of the statin drug family, which reduce the amount of cholesterol naturally produced in the liver. Zetia reduces the ... Read More

Researchers find dozens more prescription drugs can be deadly with grapefruit

Grapefruit, an excellent source of vitamin C, beta-carotene, lycopene, and other vital nutrients, becomes extremely toxic when mixed with a growing number of prescription drugs, according to a new Canadian study. Dozens of widely used drugs interact with compounds in the popular citrus fruit, triggering serious complications and even death. “The number of drugs on the market with the potential to produce serious adverse and in many cases life-threatening effects when combined with grapefruit has markedly increased over the past few years from 17 to 43 in four years,” lead researcher David Bailey of the Lawson Health Research Institute in ... Read More

Generic version of cholesterol-lowering Lipitor recalled due to glass particles in pills

More than 40 lots of Ranbaxy Laboratory’s generic version of the cholesterol-lowering drug Lipitor are being recalled in the U.S. because small glass particles were found in the pills. Ranbaxy is one of six drug companies that make a generic version of Lipitor, however Ranbaxy’s generic Lipitor sales cover nearly half of the U.S. market. The recall will cause a temporary supply disruption, and could lead to a shortage of atorvastatin, the generic name for Lipitor. The FDA is monitoring the situation, and is even reaching out to other manufacturers to mitigate the shortage. No injuries or deaths associated with ... Read More

FDA rejects Merck’s new combo cholesterol drug

Merck & Co. will have to provide more data on its experimental cholesterol-lowering drug cocktail before the Food and Drug Administration (FDA) will allow it to be sold in the United States. The drug, known only as MK-0653C, is designed to fight high cholesterol in two different ways to reduce the risk of heart attack and stroke. Merck’s new drug contains a generic version of the statin Lipitor, the top selling drug of all time. Known chemically as atorvastatin, Lipitor works to reduce the amount of cholesterol naturally produced in the liver. MK-0653C also contains Zetia, known as simvastatin, a ... Read More