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Bayer 244 articles

Experimental diabetes drug may increase ketoacidosis risk


Sanofi and Lexicon have teamed up on the development of a new diabetes drug that can treat both type 1 diabetes and type 2 diabetes. The new medication, known chemically as sotagliflozin, is in a class of diabetes drugs known as SGLT2 inhibitors, which also includes the brand name medications Invokana, Invokamet, Farxiga and Jardiance. Most type 2 diabetes medications work through the pancreas and liver. SGLT2 inhibitors work differently, blocking the absorption of glucose in the kidneys, allowing patients to excrete excess glucose through their urine. Sotagliflozin also works by targeting SGLT1 inhibitors located in the intestinal tract. SGLT2 ... Read More

Reader concerned about Xarelto bleeding side effects


“After having a pacemaker fitted, I was prescribed 20mg Xarelto (rivaroxaban),” a Daily Mail reader wrote in a message to Martin Scurr for the “Ask the Doctor” column. “I have read it was described as ‘the most dangerous drug,’ and that thousands are suing the makers. I am healthy but terrified about adverse reports.” Xarelto is in a new class of blood thinners. It is used to prevent strokes in patients with the heart condition atrial fibrillation. It is also used to treat deep vein thrombosis and pulmonary embolism, and to prevent blood clots in patients who have recently undergone ... Read More

Wrongful death lawsuit blames blood thinner Xarelto


New Jersey resident Dell Wise is suing Johnson & Johnson, Janssen Pharmaceuticals, Bayer, and their related companies over allegations that the drug companies’ blood thinner Xarelto caused the death of her aunt, Mattie Edgin, The lawsuit accuses the drug companies of acting negligently by “fervently” marketing Xarelto “with no regard to the accuracy and misrepresentations of their misleading advertisement,” citing studies that link the anticoagulant to serious bleeding events including gastrointestinal bleeds, brain bleeds, and bleeding deaths. “Due to the defective nature of Xarelto, persons who were prescribed and ingested Xarelto, for even a brief period of time, including the ... Read More

Xarelto litigation gaining momentum nationwide


Litigation involving the blood thinner Xarelto is gaining momentum nationwide. There has been an increase in filings to the multidistrict litigation (MDL), and the first trial dates are soon to be scheduled in the mass tort program in Philadelphia. The Xarelto MDL increase comes just weeks after Judge Eldon E. Fallon of the Eastern District of Louisiana issued an order to extend deadlines another 90 days for certain plaintiffs groups to serve Bayer with complaints. The order came about “due to an influx of complaints” that reportedly inundated the clerk’s office. The first bellwether trials in the Xarelto MDL have ... Read More

FDA approves Bayer’s study plan for tracking Essure side effects


The Food and Drug Administration (FDA) has given the go-ahead to Bayer’s updated post-market surveillance study plan for its non-surgical permanent birth control device Essure. The controversial contraceptive has been linked to tens of thousands of adverse events including allergic reactions, autoimmune reactions, unintended pregnancies, miscarriages and fetal deaths, and four cases of adult death. The device can also migrate from its intended position in the fallopian tubes and damage neighboring tissue and organs. Essure, made by Bayer and approved for marketing in the U.S. in 2002, consists of two nickel alloy coils that are inserted into the fallopian tubes ... Read More

Pradaxa holds edge among newer anticoagulants

blood cells

Boehringer Ingelheim’s blood thinner Pradaxa has snagged a comfortable seat among its newer anticoagulant rivals thanks to recent Food and Drug Administration (FDA) rulings. In 2010, Pradaxa became the first in the Factor Xa inhibitor class to hit the market. The drug was promoted as a more convenient alternative to the long-used warfarin for the prevention of strokes in patients with atrial fibrillation. Warfarin requires users to be monitored on a regular basis. Prescriptions soared, and so did adverse reactions reports involving bleeding events, a risk not uncommon with blood thinners. But unlike warfarin, there was no FDA-approved antidote to ... Read More

Women blame health problems on Essure birth control


At age 28, Angela Otwell had just delivered her second child and, considering her birth control options, decided to get Essure, the only FDA-approved non-surgical, permanent birth control method on the market. Compared to surgical sterilization tubal ligation, the Essure implant was less invasive and offered shorter recovery. Essure, made by Bayer, consists of two nickel alloy coils that are implanted into each of the fallopian tubes. Over about three months, scar tissue builds up around the coils, creating a barrier that is designed to prevent the sperm from reaching the egg. Otwell was implanted with the device in January ... Read More

Data shows Xarelto antidote is effective, but FDA raises concerns


Andexanet alfa, the antidote to new novel anticoagulants such as Xarelto and Eliquis, did not receive Food and Drug Administration (FDA) approval last month as anticipated because the agency raised questions about the design of the study from which approval would be based. But new data shows the medication is highly effective at reversing the bleeding effects of the newer blood thinners. Initial trial data was published early in the New England Journal of Medicine and presented at the European Society of Cardiology in Ontario because it was anticipated that andexanet alfa would be approved this August. Those early results showed ... Read More

Women who claim they were injured by Essure fighting for their day in court


Becky Beesley struggles not to cry when she thinks back on the day in 2012 that she decided to get the Essure permanent birth control. “Immediately my body rejected the procedure,” she told ABC 15 News. “My leg started to tremor and I threw up a couple of times.” Within a few months, serious health issues began to emerge. “I felt like there were little gremlins…that were just trying to claw their way out.” She says the pain became so excruciating, she had to quit her teaching job. Her doctor finally removed the implant, but the pain persisted. Beesley saw ... Read More

First four lawsuits set the stage for Xarelto bleeding events litigation


Joseph Boudreaux was prescribed the blood thinner Xarelto, but a month later he began bleeding internally so badly that he was hospitalized and required several blood transfusions. Joseph Orr’s wife used Xarelto for about a month before she died from a brain hemorrhage. Dora Mingo took Xarelto after developing blood clots, but had to discontinue treatment after she began bleeding in her gastrointestinal tract. William Henry died from a gastrointestinal bleed after taking Xarelto to prevent strokes associated with his heart condition, atrial fibrillation. These are the first four cases set to go to trial among more than 7,200 in a ... Read More