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blood sugar levels 37 articles

First-in-class cholesterol drug faring well in clinical trials

A first-in-its-class cholesterol-lowering drug is plowing through clinical trials and appears to lower LDL levels significantly more than Merck & Co’s Zetia. ETC-1002 is an oral pill made by Esperion Therapeutics. It is the first in a new class of cholesterol-lowering drugs known as ACL inhibitors. They work by reducing cholesterol synthesis in the liver and increasing LDL receptors that remove cholesterol from the blood. ETC-1002 was pitted against Zetia in a 12-week study involving 348 patients with high LDL, considered the “bad” cholesterol. ETC-1002 reduced LDL an average of 30 percent in patients who received a 180-milligram dose and ... Read More

Statins side effects may discourage older adults from exercising

Older men who take cholesterol-lowering statins are less likely to exercise than men of the same age group not taking the drugs – a trend experts say could be pushing an already inactive segment of the population to be even more inactive, lessening the benefit of statin medications. Statins, such as the widely prescribed Lipitor, are one of the most prescribed medications in the country, designed to drive down cholesterol levels and thus reduce the risk of heart attacks and strokes. Maintaining a lifestyle with healthy diet and exercise can also lower cholesterol levels and ward off cardiovascular disease, as ... Read More

FDA approves new ‘high-intensity’ sugar substitute

A new zero-calorie sweetener will soon hit store shelves, giving consumers more sugar substitute options to sweeten or add flavor to their foods, the Food and Drug Administration (FDA) announced. The new sweetener is called advatame, but does not yet have an official brand name. Advatame, along with other marketed sugar substitutes, are called high-intensity sweeteners “because small amounts pack a large punch when it comes to sweetness,” says Captain Andrew Zajac, U.S. Public Health Service (USPHS) director of the Division of Petition Review at the Food and Drug Administration (FDA). Unlike sweeteners like sugar, honey or molasses, high-intensity sweeteners ... Read More

Many preteens with high cholesterol at risk for heart problems later in life

As many as one-third of all preteens may have borderline or high cholesterol, putting them at risk of heart problems later in life, a new study suggests. The study involved 13,000 Texas preteens and will be presented at the American College of Cardiology conference this week. Researchers say it sheds light on the growing problem of high cholesterol in children and whether more can be done to prevent long-term consequences as these children age. Recently, the National Heart, Lung and Blood Institute announced new guidelines calling for every child to have a cholesterol test sometime between ages 9 and 11. ... Read More

Medical groups want children to have their cholesterol levels checked

Children ages 9-11 should have their cholesterol levels checked by their pediatricians, recommends the National Heart, Lung and Blood Institute. High cholesterol doesn’t just affect adults, it can occur in children as well. And it’s not always associated with obesity. By checking cholesterol levels in kids, doctors can identify risk factors early on to reduce their risk of heart disease as adults. The American Academy of Pediatrics recommends that children be screened after age 2 but no later than age 10. If the fasting lipid profile is normal, the test need not be repeated for another three to five years. ... Read More

Drug company sees promise in trials of first oral insulin pill

An Israeli drugmaker is doing something no company has ever done before – developing an insulin that can be taken by mouth. Clinical trials using the drug in type 2 diabetic patients are currently underway and early results are promising. Insulin therapy is important for regulating blood sugar levels in both type 1 and type 2 diabetics. Those who require insulin take it by injection –usually from a shot or pump that injects the insulin into the fat under the skin so it can get into the blood. Insulin has not been previously been available in an oral pill because ... Read More

New blood-filtering therapy can help reduce very high cholesterol levels

Cardiologists from the University of Rochester Medical Center are offering a new blood-cleansing treatment for people with extremely high cholesterol known as hypercholesterolemia. The filtering process is designed to remove excess cholesterol from the blood in an effort to reduce the risk of stroke or heart attack. “This new therapy offers a tremendous advance for patients with familial hypercholesterolemia, which is a genetic cause of very high cholesterol and relatively rare, but can be very dangerous because standard medications are ineffective in sufficiently lowering the cholesterol levels,” said Robert Block, M.D., M.P.H., a lipids expert and director of the URMC ... Read More

‘Good’ cholesterol linked to increased risk of cardiovascular disease

HDL, the so-called “good” cholesterol, may not be so good after all. A new study published in the journal Nature Medicine has linked high levels of HDL to an increased risk of cardiovascular disease. Cholesterol is a lipid, or fat, produced by the liver. It is vital for normal body function however elevated levels of cholesterol have been associated with an increased risk of heart attacks and strokes. Because of this, many people are prescribed cholesterol-lowering medications. A cholesterol reading is made up of HDLs, or “good” cholesterol, and LDL, or “bad” cholesterol. HDL is considered a “friendly scavenger” because ... Read More

Widely prescribed statins increase risk of type 2 diabetes

The cholesterol-lowering statin Crestor (rosuvastatin) is the top selling prescription medication for the 12-month period ending September 2013, according to a report from the research firm IMS Health. Crestor sold more than 23.7 million prescriptions raking in sales of $5.3 billion during that time period. Statins are commonly prescribed to lower cholesterol levels. They work by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver, which produce about 70 percent of total cholesterol in the body. Increased cholesterol levels have been associated with cardiovascular disease. Thus, statins are used to help ... Read More

Statin prescriptions – and associated side effects – likely to increase

Cholesterol-lowering statin medications are the fourth most prescribed drugs in America, and that number will likely skyrocket if new guidelines for treating the condition are adopted. The data comes from the Rochester Epidemiology Project, conducted by researchers with Mayo Clinic and Olmsted Medical Center, and funded by the National Institute on Aging and the Mayo Clinic Center for the Science of Health Care Delivery. According to the data, nearly 70 percent of Americans take at least one prescription medication, and more than half take two. Twenty percent reportedly take five or more prescription medications. The most popular medications prescribed are ... Read More