Tagged Articles

breast cancer 116 articles

Novel trials aim to speed approval of experimental breast cancer drugs

Two experimental breast cancer drugs showed promising results in a closely watched study designed to enable the accelerated approval of medication that addresses unmet medical need in the treatment of serious or life threatening conditions. The drugs include AbbVie Inc’s veliparib, a treatment for an especially aggressive type of breast cancer known as triple negative, for which there are few effective treatments, and Puma Biotechnology Inc.’s neratinib, designed to treat a different type of breast cancer known as Her2-positive. Both drugs were tested in an unconventional mid-stage trial involving patients with confirmed breast cancer whose disease is considered curable but ... Read More

Studies look at cancer risk, prevention with type 2 diabetes medications

A type of diabetes medications known as insulin sensitizers may reduce the risk of cancer by a third in women who used the drugs, a new study suggests. Insulin sensitizers include the commonly prescribed drug metformin as well as Avandia, known generically as rosiglitazone, and Actos, known generically as pioglitazone. The new study claims these insulin sensitizers were better at preventing cancer in women than diabetes drugs known as insulin secretagogues such as glyburide, glipizide and glimepiride. Type 2 diabetics are already 30 to 50 times more likely to develop cancer than those without the metabolic disorder. Women with diabetes ... Read More

FDA orders 23andMe to stop marketing genetic testing kits

DNA testing company 23andMe has been ordered by the Food and Drug Administration (FDA) to stop marketing its over-the-counter genetic test because it is being sold illegally to diagnose diseases and there is no proof the test actually works. The agency sent a warning letter to the start-up company, headed by Anne Wojcicki, the ex-wife of a Google co-founder, saying the company needed regulatory approval before it can sell its “saliva collection kit and personal genome service” in the United States. 23andMe provides a saliva analysis kit designed to help consumers determine their genetic risks for developing diseases such as ... Read More

Experts caution against statin use to lower breast cancer risk

A new study has linked high cholesterol to an increased risk of breast cancer, prompting researchers to question whether cholesterol-lowering statins could help prevent cancer. However, cancer charities cautioned that it is too soon to advise women to take statins as a preventative measure for breast cancer. Previous research has already linked obesity to an increased risk of breast and bowel cancer as well as cancers of the uterus. Fat can cause the body to excrete hormones such as estrogen, which fuels cancer growth. Researchers with Duke University Medical Center, using laboratory mice, found that cholesterol has a similar effect. ... Read More

Atossa Genetics recalls breast cancer detection device for producing false results

A medical device used to collect breast fluid and a test that uses the collected fluid to detect breast cancer are being recalled because they may produce false results. The recall comes seven months after the Food and Drug Administration (FDA) said the device needed additional clearance because changes were made after the device was approved. The recall affects Atossa Genetics MASCT (Mammary Aspiration Specimen Cytology Test) collection system and the ForeCYTE Breast Health Test. The MASCT system allows collection of nipple aspirate fluid in physician’s offices for cytological testing. The ForeCYTE Breast Health Test is an early breast cancer ... Read More

Makers of new diabetes drug hope more data will help drug win FDA approval

Blood sugar levels were improved, body weight was reduced, and blood pressure was lowered in patients who were given a new type 2 diabetes drug, according to the drug’s makers, Bristol-Myers Squibb and AstraZeneca. The treatment, known as dapagliflozin, was pitted against a placebo in clinical trials in patients with type 2 diabetes who were also taking a combination of metformin plus sulfonylurea. Dapagliflozin is a once daily pill that was approved in the European Union under the brand name Forxiga last November. It is also sold in Australia, Brazil, Mexico and New Zealand. Dapagliflozin works by removing excess blood ... Read More

Class of high blood pressure medication linked to breast cancer in postmenopausal women

Postmenopausal women who used calcium-channel blockers, a type of medication to treat high blood pressure, for 10 years or longer more than doubled their risk of developing breast cancer. Comparatively, there was no increased risk of breast cancer among women who used diuretics, beta-blockers, ACE inhibitors or angiotensin receptor blockers (ARBs) to control their blood pressure, shows a new study published online in JAMA Internal Medicine. Researchers with the Fred Hutchinson Cancer Research Center in Seattle reviewed hypertensive medication use – including recency and duration – of 880 women with invasive ductal breast cancer, 1,027 women with invasive lobular breast ... Read More

Long-term use of cholesterol-lowering statins linked to increased risk of breast cancer

A new study suggests that women who are long-term users of cholesterol-lowering statins are at 83 to 143 percent greater risk of developing breast cancer. The report, published in the journal Cancer Epidemiology, Biomarkers & Prevention, comes just weeks after news that the highly prescribed statin Lipitor increases the risk of developing type 2 diabetes, in particular among postmenopausal women with a body mass index (BMI) of less than 25. Researchers have found that statin drugs can decrease inflammation throughout the body, in particular in the blood vessels. This has led scientists to consider whether statins can also help treat ... Read More

Attorneys investigating cancer cases in patients taking type 2 diabetes drugs

An experimental type 2 diabetes drug vying for Food and Drug Administration (FDA) approval is being tested as an add-on therapy for type 1 diabetes. In January 2012, the FDA declined to approve dapagliflozin, also known by the brand name Forxiga, based on concerns over breast and bladder cancer. The drug’s makers, Bristol-Myers Squibb and AstraZeneca, said they will resubmit the application for approval before the end of the summer. Meanwhile, they are testing the drug for other indications, including a treatment for type 1 diabetes. Currently, type 1 diabetes is typically treated with insulin. Drug makers say dapagliflozin is ... Read More

FDA approves new type 2 diabetes drug, orders studies on cancer, organ risks

A new type 2 diabetes drug that works differently than all others currently on the market has been approved by the Food and Drug Administration (FDA). Invokana, made by Johnson & Johnson, is a once-a-day medication designed to lower blood sugar by flushing it out in patients’ urine. Analysts believe Invokana could generate $1 billion in annual sales, earning it the coveted “blockbuster drug” status. It is different than other type 2 diabetes medications in that it works by blocking the kidneys from reabsorbing sugar. Older drugs work by reducing the amount of sugar absorbed from food and stored in ... Read More