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cardiovascular risk 21 articles

Study: Testosterone does not improve sexual function

Testosterone replacement therapy may look like the fountain of youth, but a new analysis has found the hormone supplements don’t provide any real benefits as far as improving cardiovascular health, sexual function and cognitive abilities. What testosterone treatments do provide are a laundry list of potential health issues that render the treatments a risky gamble for men. The analysis, published in the journal PLOS One, involved a review of 226 clinical trials conducted between 1950 and 2016 in which testosterone treatments were compared to a placebo for cardiovascular health, sexual function, physical function, mood or cognitive function. “Testosterone has been ... Read More

Dallas Cowboys linebacker suspended after drug test reveals testosterone use

Little-known Dallas Cowboys offensive lineman R.J. Dill is making headlines in recent weeks, but not for making big plays. Dill was suspended for the first four games of the season after he tested positive for testosterone replacement treatments. Dill claims he was prescribed testosterone for medical reasons, and that he only started using the hormone after he failed to make a roster last year and had assumed his career was over. But that doesn’t matter to the National Football League (NFL), whose strict performance-enhancing drug-testing policy bans use of the hormone except in extraordinary circumstances, such as a player whose ... Read More

Injectable testosterone treatments more dangerous than gels, patches

Injectable testosterone treatments are more dangerous than testosterone gels or patches, according to a new epidemiologic study published this month in JAMA Internal Medicine. The study involved three large, diverse databases involving more than a half million men in the United States and Great Britain, all of whom had just been prescribed testosterone therapy after not having had any treatments of the hormone in the previous six months. The men received either injectable testosterone treatments, testosterone gels, or testosterone patches. Researchers found that the men who had received injections of testosterone had a higher short-term risk of cardiovascular events compared ... Read More

Physicians question safety of testosterone replacement therapy

Increasing numbers of physicians are questioning whether testosterone replacement therapy to boost libido, muscle mass and mood may do more harm than good. Recent studies have linked testosterone therapy to an increased risk of heart attack, stroke and death. News of the study results rang loudly throughout America, where nearly 3 percent of men older than 40 are using prescription testosterone supplements as a “fountain of youth.” And they didn’t come blindly to their doctors in search of a cure. Many were swayed by heavy marketing campaigns waged by drug companies concocting a disorder they called “Low T,” and urging men ... Read More

Repros enrolls men to test new topical testosterone treatment Androxal

Repros Therapeutics Inc. announced it has completed enrollment for one of two clinical trials pitting its topical testosterone gel alternative Androxal against other topical testosterone products currently on the market. Each trial will include 120 men, who will be divided into groups of 40 for three parallel study arms to test Androxal against an already marketed testosterone gel and a placebo. Studies will run for 17 weeks, which includes 16 weeks of dosing and one week of follow-up to gather information for the conclusion. Repros sought men who were at least 60 years of age who exhibited a normal sperm count ... Read More

FDA panel split on heart risks with non-steroidal anti-inflammatory drugs

Two Food and Drug Administration (FDA) advisory committees were split on whether data from an analysis of multiple clinical trials showed an increased risk of cardiovascular events in people using common painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs). The FDA’s Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee met jointly to review data and determine whether naproxen was less dangerous to the heart than other NSAIDs such as ibuprofen and Celebrex, as the journal The Lancet suggested. Naproxen is sold as a prescription drug under the name Naprosyn and over-the-counter under the brand name Aleve. Ibuprofen is ... Read More

Exposure to thirdhand smoke an ‘under-appreciated health risk’

The ill effects of cigarettes have been shown to affect not only smokers but also those exposed to the smoke second hand. New research shows that thirdhand smoke – the invisible remnants of tobacco smoke that clings to surfaces and dust particles – could also be putting several billion people at an “under-appreciated health risk.” Even the most courteous of smokers can be leaving behind tobacco residue that can be dangerous, say researchers from the University of California-Riverside. They reference previous studies that show children living with adults who smoke are absent from school 40 percent more days than children ... Read More

‘Good’ cholesterol linked to increased risk of cardiovascular disease

HDL, the so-called “good” cholesterol, may not be so good after all. A new study published in the journal Nature Medicine has linked high levels of HDL to an increased risk of cardiovascular disease. Cholesterol is a lipid, or fat, produced by the liver. It is vital for normal body function however elevated levels of cholesterol have been associated with an increased risk of heart attacks and strokes. Because of this, many people are prescribed cholesterol-lowering medications. A cholesterol reading is made up of HDLs, or “good” cholesterol, and LDL, or “bad” cholesterol. HDL is considered a “friendly scavenger” because ... Read More

Testosterone therapy dangerous for men who have undergone coronary angiography

Men who underwent a heart procedure known as  coronary angiography and used testosterone replacement therapy to increase their low testosterone levels were at a 30 percent increased risk of death, heart attack, or stroke, according to a study published in a recent issue of the Journal of the American Medical Association. Testosterone therapy, which includes products such as AndroGel, Testim and Axiron, has increased greatly in the past decade thanks in large part to aggressive marketing campaigns from pharmaceutical companies encouraging men to talk to their doctors about whether they have “Low T.” Low testosterone levels can be blamed for low libido, ... Read More

Studies look at cancer risk, prevention with type 2 diabetes medications

A type of diabetes medications known as insulin sensitizers may reduce the risk of cancer by a third in women who used the drugs, a new study suggests. Insulin sensitizers include the commonly prescribed drug metformin as well as Avandia, known generically as rosiglitazone, and Actos, known generically as pioglitazone. The new study claims these insulin sensitizers were better at preventing cancer in women than diabetes drugs known as insulin secretagogues such as glyburide, glipizide and glimepiride. Type 2 diabetics are already 30 to 50 times more likely to develop cancer than those without the metabolic disorder. Women with diabetes ... Read More