Tagged Articles

chemotherapy 19 articles

Experimental vaccine helps extend life of brain cancer patients

An experimental cancer vaccine helped patients with one of the most common malignant brain tumors live almost twice as long as patients who received the standard treatment of care. Glioblastoma multiforme, or GMB, is one of the most aggressive malignant brain tumors. The tumors arise from astrocytes, star-shaped cells that make up the supportive tissue of the brain. They are highly malignant because the cells reproduce quickly and are supported by a large network of blood vessels. GMB is the same tumor that affected the late Sen. Ted Kennedy. Most people with a GMB die within one year of diagnosis ... Read More

Kentucky chemotherapy center guilty of buying, selling counterfeit drugs, violating False Claims Act

The U.S. Attorney’s office for the Eastern district of Kentucky has brought criminal charges against the Hematology and Oncology Center (HOC) PLLC in Somerset, Ky., for buying and selling unapproved and mislabeled chemotherapy medicines. Natarajan Murugesa, the former office manager, also pleaded guilty to the charges, which are in violation of the Federal Food, Drugs and Cosmetics Act. The FDA’s department of Criminal Investigations and the U.S. Department of Health and Human Services’ Office of Inspector General were the ones that lead this investigation. Philip Walsky, current director of the FDA’s Office of Criminal Investigations, said, “The FDA commends the U.S. ... Read More

New chemotherapy treatment extends metastatic pancreatic cancer survival by nearly 2 months

Metastatic pancreatic cancer patients treated with Merrimack Pharmaceuticals’ experimental chemotherapy drug MM-398 in combination with the cancer drugs 5-fluorouracil (5-FU) and leucovorin survived nearly two months longer than patients treated with only 5-FU and leucovorin, the Pancreatic Cancer Action Network announced. The results come from the NAPOLI-1 phase III study, which involved three participant groups, each made up of patients with metastatic pancreatic cancer who had been previously treated with gemcitabine (Gemzar) -based chemotherapy. Participants were treated with either 5-FU and leucovorin, or a combination of MM-398 with 5-FU and leucovorin. (5-FU and leucovorin are a standard treatment option for metastatic ... Read More

Experimental vaccine shows promise against most aggressive brain tumors

More than 90 percent of patients with a highly reoccurring type of brain cancer treated with an experimental vaccine were alive six months after undergoing surgery, a far better prognosis than patients who followed standard treatment, according to a study published in the journal Neuro-Oncology and accompanied by an editorial highlighting the importance of the trial.  “The grim prognosis is exactly why new research is important,” says Orin Bloch, MD, a neurosurgeon at Northwestern Memorial Hospital and lead author of the study. The tumor, known as glioblastoma multiforme, or GBM, is the same type of tumor that took the life ... Read More

Novel trials aim to speed approval of experimental breast cancer drugs

Two experimental breast cancer drugs showed promising results in a closely watched study designed to enable the accelerated approval of medication that addresses unmet medical need in the treatment of serious or life threatening conditions. The drugs include AbbVie Inc’s veliparib, a treatment for an especially aggressive type of breast cancer known as triple negative, for which there are few effective treatments, and Puma Biotechnology Inc.’s neratinib, designed to treat a different type of breast cancer known as Her2-positive. Both drugs were tested in an unconventional mid-stage trial involving patients with confirmed breast cancer whose disease is considered curable but ... Read More

Injectable Reglan, Zofran recalled due to hazardous vial defect

Some injectable medications used to treat severe acid reflux and other gastrointestinal conditions are being recalled because tiny strands of glass were found in some vials. If the glass comes loose and is injected in to patients, it could cause serious and potentially life threatening consequences. The nationwide recall involves one lot of metoclopramide injection and two lots of ondansetron injection. Metocloparmide is known by the brand name Reglan and is used to treat gastric esophageal reflux disease (GERD), and a heartburn condition known as gastroparesis in diabetics. Ondansetron, known by the brand names Zofran and Zuplenz, prevents nausea and vomiting ... Read More

FDA approves new type of breast cancer treatment

The Food and Drug Administration (FDA) has approved a first-of-a-kind breast cancer cocktail designed to kill tumor cells while sparing healthy ones. The new drug, Kadcyla, made by Roche, contains Herceptin, an established breast cancer treatment, with a powerful chemotherapy drug, and a third chemical that binds the two medicines together. Researchers say the Kadcyla may be more beneficial for some breast cancer patients because it delivers more medicine and has fewer side effects. Kadcyla is indicated for patients with HER2-positive breast cancer, an aggressive form of the disease that generally does not respond well to hormone therapy. About 20 ... Read More

Hospira recalls ovarian cancer drug due to visible particles in vials

Drug company Hospira, Inc., is recalling three lots of the advanced ovarian cancer treatment Carboplatin injection because of visible particles found in samples taken from the lots during a routine inspection. The particles have been identified as Carboplatin crystals. If injected into a patient, the particles may become lodged in and obstruct blood vessels, potentially causing local infraction, thromboembolism (blood clots), and vasculitis (inflammation of blood vessels). Over time, granulomatous, or a noncancerous inflammation in the tissue, can form in the lungs. Hospira issued the updated recall notice just five months after it issued a recall notice on 19 lots ... Read More

Drug company stock drops after news that drug data was flawed

It was a great day for Peregrine Pharmaceuticals when earlier this month during a midpoint review of a clinical trial the company announced that lung cancer patients taking its experimental drug bavituximab were living twice as long as patients who were treated with chemotherapy alone. The company’s stock shot up and last Friday had reached a three-year high. Monday, however, the price of Peregrine stock plummeted after news of a major discrepancy between some patient sample test results and treatment code assignments. Bavituximab is being studied as a second option for non-small cell lung cancer and as a primary treatment ... Read More

Bristol-Myers Squibb recalls chemotherapy drug

More than 31,000 units of a chemotherapy drug are being recalled by manufacturer Bristol-Myers Squibb Co., because one vial was found to be overfilled, which puts patients at risk for overdose. The recall affects 10 lots of BiCNU, an injection of the drug carmustine, which is used to treat brain tumors, multiple myeloma, Hodgkin’s disease and non-Hodgkin’s lymphoma. An overdose of BiCNU could result in lung or kidney toxicity. No adverse events have yet been reported. BiCNU was manufactured by Ben Venue Laboratories, a manufacturing contractor that Bristol-Myers Squibb no longer uses. The recall affects products sold in the United ... Read More