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cystic fibrosis 8 articles

Contaminated stool softener linked to bacterial infections in critically ill patients

A contaminated oral docusate stool softener may be to blame for a multi-state outbreaks of Burkholderia cepacia infections, caused by a bacteria that can cause potentially serious respiratory infections, especially in patients with cystic fibrosis, the health officials warn. An investigation by the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) have found that the infections have occurred primarily in patients with cystic fibrosis who are receiving treatment in intensive care units. A contaminated liquid docusate product was identified as a possible culprit in cases in one state. Preliminary information still indicates that contaminated oral ... Read More

Glass particles found in inhaled respiratory treatment

Ben Venue Laboratories has issued a nationwide recall of an inhaled Acetylcysteine solution to treat specific respiratory conditions because of the possibility of glass particles in the solution. Inhaling these particles can cause airway obstruction that can lead to choking, wheezing, difficulty breathing, coughing and possibly hemoptysis, or blood in the mucus. These problems can be life threatening and could also result in recurrent infections due to obstruction of airways and decreased clearance of airway secretions. Acetylcysteine is a drug that is inhaled to clear mucus and material entrapped in mucus in people who have thick mucus that may interfere ... Read More

FDA approves first newborn screening test for intellectual disabilities

Federal drug regulators have granted approval for a first-of-its-kind blood test that can detect intellectual disabilities in infants by scanning variations in patients’ chromosomes that are linked to many developmental disorders. The laboratory test, known as CytoScan Dx Assay is made by medical technology company Affymetrix. It is the first FDA-approved test that analyzes the whole genome in a single procedure at very high resolutions. An intellectual disorder is a condition in which a person has limitations in mental functioning and skills such as communicating, taking care of him- or herself, and social skills. These limitations will cause a child ... Read More

Contaminated lot of Zicam nasal spray recalled

One lot of Zicam Extreme Congestion Relief nasal gel, an over-the-counter medicine used to treat nasal congestion and sinus pressure, is being recalled because an organism was found in a single sample during a routine review at the manufacturing plant where the medicine is produced. The contaminant, known as Burkholderia cepacia, poses no risk to healthy individuals but in a nasal spray could cause upper airway colonization and secondarily lead to respiratory infections in people with a compromised immune system or people with chronic lung conditions such as cystic fibrosis. Burkholderia cepia is also resistant to many antibiotics and may ... Read More

Disinfectant, antiseptic swabs and wipes recalled due to possible contamination

Selected lots of benzalkonium chloride swabs and antiseptic wipes manufactured for DUKAL by Jianerkang Medical Dressing Co. and sold over-the-counter and in kits are being recalled because of potential microbial contamination with Burkholderia cepacia. All customers are advised to discontinue use of the recalled products immediately as using them could lead to infections, some of which pose certain health risks for immune-suppressed patients. Burkholderia cepacia is an important human pathogen that often causes pneumonia in people with underlying lung diseases such as cystic fibrosis or chronic granulomatous disease. For average healthy people, the presence of Burkholderia cepacia on the recalled products ... Read More

FDA to consider approval of personalized DNA testing kit to determine disease risk

Genetic test maker 23andMe has applied for Food and Drug Administration (FDA) approval of a saliva-based DNA test that would enable consumers to look at their genetic code for information about their ancestry and what diseases they may develop in the years to come. Such personalized kits have caught flack for claiming to help users detect if they are likely to develop diseases such as breast cancer, heart disease and Alzheimer’s disease. Geneticists say that how DNA variations lead to certain diseases is still poorly understood and that tests that claim to predict these risks is not reliable. But the ... Read More

FDA approves breakthrough treatment for cystic fibrosis

The Food and Drug Administration (FDA) has approved the first drug that target the underlying cause of the lung disease Cystic Fibrosis, a move that is being heralded by the Cystic Fibrosis Foundation. The drug, developed by Vertex Pharmaceuticals Inc., and funded in large part by CF Foundation, will be sold under the brand name Kalydeco. It is indicated for a segment of CF patients ages 6 and older who have the G551D mutation of the disease. This mutation is present in roughly 4 percent of CF patients in the United States. In people with this mutation, a defective protein ... Read More

Asthma meds may cause newborn endocrine, metabolic disorders

Pregnant women who use inhaled glucocorticoids to relieve breathlessness that occurs randomly with asthma may be increasing their child’s chances of developing endocrine or metabolic disorders, according to a new study published in the American Journal of Respiratory and Critical Care Medicine. The study was based on a review of 65,085 mother-child pairs from the Danish National Birth Cohort. Researchers found that children who were exposed to glucocorticoids in utero were nearly 80 percent more likely to develop some type of endocrine or metabolic disorder by the age of 6. The risk was dependent on the frequency of use of ... Read More