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dangerous side effects 20 articles

Lifestyle intervention does not reduce risk of heart attacks, strokes in type 2 diabetics

A controlled diet and exercise plan may help patients with type 2 diabetes lose weight, but the weight loss did not reduce their risk for having heart problems, a new study shows. The study, sponsored by the National Institutes of Health (NIH), looked at the long-term effects of healthy nutrition and exercise in overweight people with type 2 diabetes. More than 5,000 obese adults ages 45 to 76 with type 2 diabetes were followed for nearly 10 years. Half of the participants focused on lifestyle intervention through physical activity and low calorie intake, and the other half was given conventional ... Read More

Roche stops development of type 2 diabetes drug because of safety, efficacy concerns

Drug maker Roche has stopped development of the experimental type 2 diabetes treatment aleglitazar because of undesirable side effects and a lack of efficacy. The decision was based on a recommendation by the independent Data and Safety Monitoring Board, which conducted a regular safety review of the aleglitazar AleCardio phase III trail. The drug was being tested in patients with a recent acute coronary syndrome event and type 2 diabetes. Patients reportedly suffered from side effects to the kidneys and the heart. “The safety of patients is our first priority. Roche is working with investigators to support the management of ... Read More

Class of type 2 diabetes drugs linked to acute pancreatitis, pancreatic cancer, thyroid cancer

Concerns over the safety of a class of type 2 diabetes drugs known as incretin mimetics – glucagon-like peptide-1 (GLP-1) agonists and dipeptidylpeptidase-4 (DPP-4) inhibitors – took a sharp turn recently after an investigative report by British media revealed that it uncovered unpublished data that links the drugs to “unwanted proliferative or inflammatory pancreatic effects,” and that drug regulators in the United States and Europe have not responded quickly enough to studies that suggest these drugs are not as safe as manufacturers claim. Incretin mimetic drugs include exenatide (Byetta, Bydureon), liraglutide (Victoza), sitagliptin (Januvia, Janumet, Janumet XR, Juvisync), saxagliptin (Onglyza, ... Read More

Researchers receive funding for innovative new blood thinner

Researchers have received financial support to develop a new kind of blood thinner they believe may prevent life threatening blood clots without causing major bleeding events, a dangerous side effect to currently marketed anticoagulants. Index Ventures is teaming up with GlaxoSmithKline and Johnson & Johnson to create X01, a new company formed to develop experimental drugs. The new $11 million venture early-stage biotech fund will help fund research into the innovative blood thinner ichorcumab. The drug is still in the very early stages of development with clinical trials not expected for at least another two years. However, financial analysts say ... Read More

Cost of diabetes rising as number of diabetics increases

The cost of diabetes rose more than 40 percent during the past five years, however the per-patient cost has remained roughly flat, according to new research that will be published in the April issue of Diabetes Care. The study, commissioned by the American Diabetes Association, estimated that diabetes cost the nation $245 billion in 2012, compared to $174 billion in 2007. Comparatively, an estimated 22.3 million people were diagnosed with the disease in 2012, compared to about 17.5 million in 2007. John Anderson, president of medicine and science for the American Diabetes Association, said the data shows the rising cost ... Read More

New social media program targets prediabetics

A new social media program designed to provide regular and aggressive support for people with prediabetes was launched this week. Called Prevent, the first-of-its-kind the program matches prediabetics into small online communities based on their age, body mass index, and location. Participants are mailed a wireless scale that transmits the participant’s weight to the online system on a daily basis. Participants not only can monitor their own progress, but also the progress of other members (shown as a percentage of body weight lost) of their online community. The 16-week program introduces a new behavior change each week, then provides support ... Read More

Analyst: diabetes drug sales expected to more than double by 2020

Sales of diabetes drugs should keep growing at about 10 percent a year for the rest of the decade, reaching $65 billion a year by 2020, says Jeffrey Holford, an analyst with Jefferies & Co. At that pace, diabetes drug revenues should more than double from the current $30 billion by the decade’s end. Holford says diabetes drug revenues should rise in relation to the aging population in the West, while in emerging markets, diabetes and obesity are increasing and access to health care is also growing. Other factors considered include higher drug prices, strong patent protection for key drugs, ... Read More

Paula Deen won’t change her ways too much due to diabetes diagnosis

TV celebrity chef Paula Deen says she’s willing to offer up lighter versions of her fatty Southern recipes, but she refuses to change her style of cooking just because she was diagnosed with type 2 diabetes. The Food Network star went public about her diabetes last month – three years after diagnosis – when she landed an endorsement deal for Victoza, a new diabetes treatment. Deen told the Associated Press, “I am who I am. But what I will be doing is offering up lighter versions of my recipes. … I will have a broader platform now, trying to do ... Read More

Could birth control pill affect your preferences for partners?

Could your birth control pill be affecting your preferences for romantic partners? Researchers say there is evidence that contraceptives alter both a woman’s and a man’s perception of attractiveness. A review of data on the topic was recently published in the journal Trends in Ecology and Evolution and reported in the Wall Street Journal. According to researchers, both men’s and women’s preferences in partners change when a woman is ovulating. This was tracked in various studies by gauging women’s responses to photographs of different men or interviewing women about their feelings for men over several weeks. The studies show that ... Read More

Alert your friends to the dangers of Yaz, Yasmin

When Yaz and Yasmin hit the market, they were touted to be different than other birth control pills because they could curb the annoying symptoms of premenstrual syndrome (PMS) and even clear up unsightly acne. The marketing campaign worked quite well for Bayer HealthCare. The pills became the No. 1 selling oral contraceptives in the United States, with many of its users being young women and teenagers who asked their doctors for the pills by name. But the honeymoon would soon end for Bayer, as reports of potentially fatal side effects from Yaz and Yasmin began to surface. Bayer was ... Read More