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Study investigates testosterone side effects

Last year, the Food and Drug Administration (FDA) ordered manufacturers of testosterone replacement products to add blood clot warnings to the safety labels of the hormones. A new study suggests testosterone supplements may not increase the risk of blood clots, but the risk for heart attacks and strokes in patients who use the therapy remains. The most common forms of blood clots in the veins, also known as venous thromboembolism (VTE), are deep vein thrombosis (blood clot in the leg) and pulmonary embolism (blood clot in the lungs). It is the third most common cardiovascular problem after heart attacks and ... Read More

FDA strengthens heart attack, stroke warnings on NSAIDs

The Food and Drug Administration (FDA) is strengthening existing warnings on the labels of prescription and over-the-counter (OTC) nonsteroidal anti-inflammatory drugs, or NSAIDs, to indicate that use of the drugs can increase the risk of heart attack or stroke, either of which can result in death. Those serious side effects can occur as early as the first few weeks of using a NSAID, and the risk may increase the longer a person takes the drugs. NSAIDs are used for the temporary relief of a variety of pains and fever, and include a range of brand names and generics. NSAIDs include ... Read More

Study: Testosterone not linked to increased prostate cancer risk

Elevated testosterone levels – either naturally occurring or from use of testosterone replacement therapy (TRT), does not increase prostate-specific antigen (PSA) levels or prostate cancer risk, according to new research. “Many urologists are concerned that TRT may accelerate prostate growth not only in benign disease but also in cancer,” said Peter Boyle, MD, with the International Prevention Research Institute in Ecully, France. The theory is that most prostate cancers respond to androgen deprivation therapy. Thus, testosterone is thought to stimulate prostate growth and prostate cancer. Boyle set out to identify whether there is a link between testosterone and prostate cancer ... Read More

FDA panel recommends heart failure warning for Type 2 diabetes drugs

The Type 2 diabetes drugs Onglyza and Kombiglyze should carry warnings that use of the medication may cause heart failure and death, a Food and Drug Administration (FDA) advisory panel warned. The recommendation is based on the expert panel’s review of a 16,000-patient study that looked at heart health among patients taking either Onglyza or Kombiglyze. Panel members voted 14-1 to recommend that the drugs’ safety labels should include information to alert patients that using the drugs could lead to an increased risk of hospitalization for heart failure and death from any cause. Despite this risk, panel members voted 13-1, ... Read More

Alabama fireworks factory explosion kills two workers, injures four others

OWENS CROSS ROADS, Ala. — A north Alabama fireworks factory explosion Friday morning that left two women dead and four other employees injured was not the first deadly blast at the plant. Family members of some of the victims of Friday’s explosion condemned Ultratec Special Effects for its poor history of worker safety. The plant, which produces pyrotechnic special effects and displays for movies, concerts, and other events, was racked by another explosion in 1999 that killed one person. Aimee Cothran Bearden’s family told Huntsville’s WHNT that “Aimee was killed doing a job she was dedicated to, because she was ... Read More

First-time users of testosterone replacement treatments are at greater risk of heart attack

Men using testosterone replacement treatments are at greater risk of suffering a heart attack during the first 90 days of treatment than men who have been on the hormone replacement for more than four months. They were also at greater risk of heart attack compared to men who had used the treatment and discontinued use, according to a new study published in the journal Pharmacotherapy. The study involved data from the IMS LikeLink database for new-onset heart attacks in men ages 45 to 80 who had filled at least one prescription for testosterone replacement therapy. Researchers looked at current users ... Read More

Adverse events linked to misuse of IV training solutions

Numerous patients have fallen ill and one died after receiving infusions of saline products intended for training purposes and not for human use, the Centers for Disease Control and Prevention (CDC) reported. The products involve Wallcur’s simulated intravenous (IV) saline solutions, which were inadvertently distributed to medical clinics, surgical centers and urgent care facilities in numerous states. More than 40 patients were injected with the IV training solutions, and many experienced adverse events including fever, chills, tremors and headaches. Some patients were hospitalized, and one death has been associated with use of the product though the CDC says it is ... Read More

Testosterone replacement therapy can boost sex drive in women, but there are side effects

Women who suffer from hypoactive sexual desire disorder (HSDD), a common female sexual dysfunction, may benefit from testosterone replacement therapy, says Dr. John E. Buster, professor of Obstetrics and Gynecology, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University in Providence. HSDD is diagnosed when the loss of sexual desire causes emotional distress enough for a woman to complain to her doctor. It is caused by a drop in androgens from adrenal receptors and ovulatory failure from menopause, which is a natural part of female aging. “Transdermal testosterone, even in modest doses, is highly effective ... Read More

Cyclist Santambrogio suspended after testing positive for testosterone supplement

Italian professional road racing cyclist Mauro Santambrogio says he tested positive for testosterone because he was prescribed the therapy by a urologist to treat erectile and fertility problems and to help him father a child with his new girlfriend. Santambrogio, who was due to race with the Amore e Vita Continental team in 2015, was suspended after he was tested positive for the male hormone by the Union Cycliste International (UCI), the world governing body for sports cycling and overseer of international competitive cycling events. Santambrogio says he informed officials when he was tested that that he had just completed ... Read More

Testosterone increases colon cancer incidence in lab rats

The male hormone testosterone may cause cancerous tumor growth in the colon, according to new research. Researchers at the University of Missouri College of Veterinary Medicine observed normal levels of naturally occurring colon cancer in a group of male rats. When the testosterone was removed from those rats, colon cancer rates decreased dramatically. When the testosterone was reintroduced, the colon cancer rates returned to normal. It was previously thought that female hormones may have offered some protection against tumor susceptibility. “However, by showing that removing testosterone from rats leads to a dramatic decrease in colon cancer susceptibility, it appears that ... Read More