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estrogen 57 articles

Label of Estring menopause treatment updated to include estrogen-class standards

The black box warning and other warnings and precautions on the hormonal postmenopausal symptom reliever Estring have been updated to reflect current recommended estrogen-class labeling standards which include risk of uterine cancer, breast cancer, heart attack, stroke, blood clots and dementia. Estring is a vaginal ring made by Pfizer that contains estradiol, a synthetic estrogen. It is inserted into the vagina and should be removed after 90 days of continuous use. Estring is used after menopause to treat moderate to severe vaginal itching, burning and dryness, painful intercourse, urinary urgency and painful urination due to urogenital atrophy. Hormone replacement therapy, ... Read More

Osteoporosis drugs may not lower breast cancer risk in postmenopausal women

Osteoporosis drugs known as bisphosphonates may not help prevent breast cancer in women, a new study suggests. Bisphosphonates, sold under the brand names Fosamax and Reclast, are used to treat postmenopausal osteoporosis, a disease that weakens the bones and increases the risk of sudden and unexpected fractures. There is a direct link between the lack of estrogen after menopause and the development of osteoporosis. However, lower estrogen levels are also associated with a lower breast cancer risk. It was assumed after several observational studies that bisphosphonates helped protect women from breast cancer. But when researchers from University of California San ... Read More

NuvaRing makers covered up blood clot risks with contraceptive device

Early one morning in June 2008, Lyndsey Agresta, then 27, called her mother and asked for help. She had an unbearable headache and asked her mother to drive her to the emergency room and look after her 5-year-old son. That was when “everything changed,” her mother, Diane Agresta recalls. Doctors discovered bleeding on her brain caused by a blood clot. It was an unusual diagnosis for a young woman, and doctors suspected her NuvaRing contraceptive device likely contributed to the blood clot. Doctors surgically removed two-thirds of Lyndsey’s right cerebral hemisphere, which left her paralyzed and in need of round-the-clock ... Read More

Birth control pills may help protect athletic women from lingering effects of head injury

Women who suffer head injuries within the two weeks before their period have a slower recovery time and poorer health up to one month after their injury, according to a new study, prompting researchers to suggest that women who participate in sports that put them at risk for head injuries may benefit from taking birth control pills. Previous studies have suggested that women who experience head trauma have greater cognitive decline, slower reaction time, more headaches, longer periods of depression, longer hospital stays and longer delays before returning to work, compared to men who suffer head injuries. The outcomes are even ... Read More

Experts caution against statin use to lower breast cancer risk

A new study has linked high cholesterol to an increased risk of breast cancer, prompting researchers to question whether cholesterol-lowering statins could help prevent cancer. However, cancer charities cautioned that it is too soon to advise women to take statins as a preventative measure for breast cancer. Previous research has already linked obesity to an increased risk of breast and bowel cancer as well as cancers of the uterus. Fat can cause the body to excrete hormones such as estrogen, which fuels cancer growth. Researchers with Duke University Medical Center, using laboratory mice, found that cholesterol has a similar effect. ... Read More

Combination birth control pills discouraged for older women who smoke

A new black box warning will be added to the safety labels of several brands of estrogen-plus-progestin birth control pills urging women who are older than 35 years of age who smoke not to use the medication because it greatly increases their chances of having a heart attack or stroke. Black box warnings, or boxed warnings, are the strongest warning the Food and Drug Administration (FDA) requires, and signifies that medical studies indicate that using a drug carries a significant risk of serious or even deadly adverse effects. The warnings will be placed on the following oral contraceptives: Modicon (norethindrone/ethinyl ... Read More

FDA approves new extended regime oral contraceptive

Quartette, a new generation of extended regime oral contraceptives, has been approved by the Food and Drug Administration (FDA), Teva Pharmaceuticals announced. The combination levonorgestral/ethinyl estradiol and ethinyl estradiol tablets are designed to minimize breakthrough bleeding between scheduled periods. Breakthrough bleeding is a common side effect with extended regime birth control pills, especially during the first few months, and one of the main reasons why women give up on the pills. The estrogen in Quartette increases at specific points and provides four short, light periods a year. FDA approval is based on a series of clinical trials involving more than ... Read More

Study suggests timing of HRT affects dementia risk

How soon after menopause a woman uses hormone replacement therapy (HRT) may determine her risk for developing dementia, a new study published online in the journal Neurology suggests. The numerous studies conducted on the effects of HRT in women have come to different conclusions about whether the menopause treatment lowers or raises a woman’s risk for Alzheimer’s disease and dementia. Observational studies, or those that follow a group over a period of time, show a reduced risk of dementia in women who use HRT, whereas clinical trials, which test the effects of a drug against placebo, show an increased risk. ... Read More

Ortho Evra birth control patch now warns of death, permanent disability from blood clots

Stronger warnings have been placed on packages of the Ortho Evra birth control patch, informing users that studies suggest women who use the patch are at greater risk of developing potentially life-threatening blood clots than women who use some oral contraceptives. Birth control pills with the combined hormones estrogen and progestin carry a risk for blood clots. Ortho Evra is a combined hormone contraceptive, containing the progestin norelgestromin and the estrogen ethinyl estradiol. The patch is a thin, matrix-type transdermal patch that is applied to the skin and gradually releases the active ingredients to stop ovulation in order to prevent ... Read More

FDA approves new drug to treat most common form of breast cancer

A new drug to treat the most common form of breast cancer has been approved by the Food and Drug Administration (FDA). Afinitor (everolimus) in combination with Aromasin (exemestane), won approval for the treatment of some postmenopausal females with advanced hormone-receptor positive, HER2-negative breast cancer. The drug is indicated for patients with progression or recurrence of breast cancer after receiving Arimidex (anastrozole) or Femara (letrozole). Both Arimidex and Femara are aromatase inhibitors, which work by depriving cancer tumors of the hormone estrogen, which can fuel their growth. However, over time, these tumors can become resistant to those drugs. The addition ... Read More