A new contraindication is being added to birth control pills and other treatments containing the hormone ethinyl estradiol regarding the use of these drugs with certain hepatitis C (HCV) drug combinations. Specifically, using HCV drug combinations containing ombitasvir, partiaprevir/ritonavir, with or without dasabuvir is contraindicated because there is a risk for liver enzyme elevations. This was observed in clinical trials with women using ethinyl estradiol-containing medications, such as combined oral contraceptives. These women were significantly more likely to have ALT elevations that in some cases was greater than 20 times the upper limit of normal. ALT, or alanine transaminase, are ... Read More
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