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FDA: Invokana, Invokamet linked to foot, toe amputations

People who take the type 2 diabetes medication Invokana or Invokamet, both of which contain the active drug ingredient canagliflozin, are at an increased risk of foot amputations, mostly affecting the toes, the Food and Drug Administration (FDA) warned. The Safety Alert comes just weeks after the European Medicines Agency (EMA) announced that it was conducting an investigation into reports of lower limb amputations, specifically toe amputations, with the drug. The FDA said that results from an ongoing clinical trial found an increased risk of foot and toe amputations in patients treated with Invokana and Invokamet. The agency said it ... Read More