Tagged Articles

gastroesophageal reflux disease 23 articles

PPI treatment Prevpac linked to serious hypersensitivity reactions

A new hypersensitivity reaction warning has been added to the safety label of the prescription proton pump inhibitor (PPI) Prevpac, a package of medications used to treat stomach ulcers, gastroesophageal reflux disease (GERD), damaged esophaguses, and conditions that cause the stomach to produce too much acid. Prevpac consists of a daily administration card containing two PREVACID (lansoprazole) 30 mg capsules, four amoxicillin 500 mg capsules, and two clarithromycin 500 mg tablets. The drugs treat or prevent infections that are proven or strongly suspected to be caused by bacteria. The new warnings inform health care providers to immediately discontinue use and ... Read More

Metozolv label has new tardive dyskinesia warning

The new chewable heartburn medication Metozolv, an orally disintegrating version of Reglan (metoclopramide), has added a warning to its label alerting users of a risk of the serious movement disorder Tardive Dyskinesia with long-term use of the drug. The change to the drug’s safety label was approved by the Food and Drug Administration (FDA) and announced this month. The updated information to the drug’s WARNINGS section reinforces the Boxed Warning that was added to all metoclopramide-containing drugs in June 2009. The new warning states, “Treatment with metoclopramide can cause Tardive Dyskinesia (TD), a potentially irreversible and disfiguring disorder characterized by ... Read More

Reglan as morning sickness treatment still carries risks for mom

A study into the safety of the anti-nausea drug metoclopramide, also known as the brand name Reglan, on pregnant women indicates that the drug is safe in mothers and their unborn children, according to a first-time study of the drug’s affects on expectant mothers. The drug is not indicated for pregnant women but the drug has an off-label indication for the treatment of morning sickness. Metoclopramide is approved by the Food and Drug Administration (FDA) to treat severe heartburn, gastroesophageal reflux disease (GERD), and gastroparesis. Last year, the federal agency ordered a black box warning be placed on the drug ... Read More

FDA, CSPC urge parents to stop using dangerous sleep positioners

Parents and caregivers of infants are being warned not to put babies in sleep positioning products because of the risk of death due to suffocation. The warnings were issued by both the Food and Drug Administration (FDA) and the Consumer Product Safety Commission (CSPC) after reviewing reports of 12 known infant deaths associated with the products. Sleep positioners are thin mats or wedges used to either elevate the baby’s head or keep the baby in a desired position while sleeping. They are often used with infants under 6 months of age. Some manufacturers claim the products help prevent Sudden Infant ... Read More

Reglan users blame depression, suicidal thoughts on heartburn drug

The prescription drug Reglan, also known by the generic metoclopramide, is taken by more than 2 million people to treat the symptoms of gastrointestinal problems such as severe heartburn, gastroesophageal reflux disease (GERD) and gastroparesis. Many people have become aware of the drug’s serious side effects, including the debilitating neurological disorder known as Tardive Dyskinesia in which the muscles move involuntarily. Reglan’s safety label now includes an FDA black box warning for the risk of the disorder. But another serious condition is being blamed on the medication – suicidal ideation. “My life is unbearable because of Reglan, and if the ... Read More

GERD sufferers sought for study on investigational heartburn treatment

Researchers in Sacramento, Calif., are looking for people who still experience troublesome symptoms of gastroesophageal reflux disease (GERD) even while taking heartburn medication, to participate in a study to evaluate an investigational heartburn treatment. Symptoms of GERD include heartburn, or a burning sensation under the breastbone, burning in the back of the throat due to regurgitation of stomach acid, nausea and vomiting. If left untreated, GERD can result in painful inflammation or ulcers in the esophagus, scar tissue in the esophagus, Barrett’s esophagus, cough and asthma, inflammation and infection in the lungs, inflammation of the throat and larynx, and even ... Read More

Pepcid linked to serious skin reaction

Famotidine, the heartburn drug most known by the brand name Pepcid, is yet another drug that has been linked to a deadly skin reaction known as toxic epidermal necrolysis (TEN), the most serious version of Stevens Johnson Syndrome (SJS). Famotidine is available by both prescription and over-the-counter in either a tablet or suspension (liquid) that is taken by mouth. It is in a class of medications called H2 blockers and works by decreasing the amount of acid made in the stomach. Famotidine is used to treat ulcers, gastroesophageal reflux disease (GERD), and conditions where the stomach produces too much acid. ... Read More

Acid reflux study may lead to new treatments

A team of researchers in India hope a new tool for identifying acid reflux disease will lead to improved treatments for the more than 15 million Americans who suffer from the bothersome symptoms. The tool is a molecular imaging device that allows researchers to study the differences between a healthy esophageal muscle and an unhealthy one. When a person with a normally functioning digestive system swallows, the lower esophageal sphincter acts as a trap door by relaxing and allowing for food and liquids to move into the stomach. Then the muscle tightens, closing this door. For people who suffer from ... Read More

Man suffers permanent disability from heartburn drug

When 57-year-old August Macaluso, a former nuclear-plant maintenance worker in Charlotte, N.C., began shaking violently, blinking incessantly and slurring his speech, he and his wife Sharon were both puzzled. Desperate for answers, Sharon Googled his symptoms and learned that the drug her husband had been taking for just three months was linked to the involuntary movement disorder Tardive Dyskinesia with frighteningly similar symptoms. He stopped taking the drug and after a battery of medical tests, doctors confirmed the Macalusoes’ worst fears. August had suffered permanent damage. Reglan (metoclopramide) was approved by the Food and Drug Administration in 1979 for the ... Read More

Less common symptoms of GERD can make diagnosis difficult

Gastroesophageal reflux disease, or GERD, affects as many as 40 percent of the population. The nagging symptoms of frequent heartburn, upset stomach and an acid taste in the back of the throat can help identify the condition. But some less common symptoms can make the diagnosis more difficult to pinpoint. “I recently met a lady visiting from Iran. She has been coughing for seven years. She had seen numerous physicians and had been tested extensively in Iran. She had no word for heartburn although she described, through a translator, ‘a volcano going off in my chest,’” writes Dr. Kurt Barrett ... Read More