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gastrointestinal bleeding 6 articles

New boxed warnings added to prescription NSAIDs

The safety labels for prescription painkillers known as nonsteroidal anti-inflammatory drugs (NSAIDs) have been updated to include a new black box warning for risk of serious cardiovascular and gastrointestinal events. Boxed warnings are the most serious type of warning issued by the FDA and involve situations in which there is a significant risk of serious or even life-threatening adverse events. The boxed warnings state the following: Cardiovascular Thrombotic Events Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction (heart attack) and stroke, which can be fatal. This risk may occur early in treatment ... Read More

Chinese pet treats sickened thousands of animals; will humans be next?

The rash of pet illnesses and deaths from possibly tainted jerky treats made in China has raised questions whether federal officials are doing enough to endure imported foods are thoroughly inspected and deemed safe for humans. More than 3,600 dogs and 10 cats were sickened or died after eating the jerky treats, however the Food and Drug Administration (FDA) says it has yet to identify what in the treats made the animals sick. About 580 of the cats and dogs that fallen ill have died from health problems including kidney failure and gastrointestinal bleeding. In an effort to identify the ... Read More

FDA issues update on ongoing review of serious bleeding with blood thinner Pradaxa

Pradaxa

The Food and Drug Administration (FDA) announced it has evaluated new information about the risk of serious bleeding associated with use of the blood thinners dabigatran (Pradaxa) and warfarin (Coumadin, Jantoven, and generics), and determined that bleeding rates with Pradaxa do not appear to be higher than bleeding rates with warfarin, despite the high number of adverse event reports the agency has received about Pradaxa. The FDA, however, says it is continuing to evaluate multiple sources of data in the ongoing safety review of this issue. Pradaxa was approved in 2010 to prevent strokes in patients with a heart condition ... Read More

SSRIs may increase stroke risk

Taking the most common type of antidepressant can increase the risk of certain types of strokes, according to a study published in the journal Neurology. The new research builds on previous studies that linked use of selective serotonin reuptake inhibitors (SSRIs) to major bleeding, such as gastrointestinal bleeding. SSRIs include brand name drugs Zoloft, Paxil, Lexapro and Prozac. SSRIs are thought to inhibit the clumping together of platelets, which could cause internal bleeding. The new study focused on antidepressant use and stroke. Canadian researchers analyzed 16 studies and found that of the combined 500,000 participants, those taking SSRIs were 51 ... Read More

Cardiology group compares safety of blood thinners

A group of researchers from the European Society of Cardiology have found what they say is the best-documented alternative to the blood thinners warfarin and aspirin for the prevention of stroke in patients with a type of irregular heartbeat known as atrial fibrillation. But the most preferred drug has yet to be approved for use in the United States. Recently published results of this new research say Apixaban (Eliquis), made by Pifzer and Bristol-Myers Squibb, “has been shown to be superior compared with warfarin concerning the reduction of stroke and mortality in combination with a reduction in major bleeding, with ... Read More

Aspirin + SSRIs = risk of bleeding

Patients who take a blood thinning agent, such as aspirin, after suffering a heart attack who also take  selective serotonin reuptake inhibitors, or SSRIs, are at increased risk for bleeding, according to a Canadian study. Both types of drugs have been associated with an increased risk of bleeding, but the new analysis shows that when the drugs are combined, patients increase their risk by 40 percent or more. The study looked at data from 27,058 patients aged 50 and older who were discharged from the hospital after a heart attack between January 1998 and March 2007. Following discharge, 14,426of the ... Read More