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heart failure 50 articles

Many breast cancer patients don’t seek prompt treatment for drug-related heart failure

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About 12 percent of breast cancer patients treated with chemotherapy drugs develop heart failure within three years after cancer treatment, but only a third saw a cardiologist within 90 days of the onset of symptoms, according to a new study. The research was presented at the American Cancer Society meeting in Baltimore. The study involved data from about 8,400 breast cancer patients age 65 and older who were treated either with chemotherapy drugs called anthracyclines, or a targeted therapy trastuzumab. Both drugs have been previously linked to heart problems. Researchers said that patients who saw a cardiologist were more likely ... Read More

Hospira recalls injectable heart drug due to contamination with glass particles

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Hospira is recalling another injectable drug due to the presence of visible particle matter floating in the vials, the Food and Drug Administration (FDA) has announced. This latest recall involves one lot of Dobutamine Injection, used to treat heart failure and help the heart pump blood. The recall was issued after a customer reported discolored solution in a vial of Dobutamine. Upon further review, a chip in the neck of the glass was identified as well as glass particulate within the solution. To date, no adverse events have been linked to this recall. If the solution with particulate is injected ... Read More

Fictional Dr. House character helps solve real-life medical mystery

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Doctors were stumped by the symptoms exhibited by the 55-year-old man with severe heart failure. He had fever, swollen lymph nodes, hearing and vision loss when he arrived at the Center for Undiagnosed Diseases in Marburg, Germany. He also had a metal hip implant that replaced a previous ceramic one. The team of German doctors was no stranger to medical mysteries. They use a variety of resources to help pinpoint difficult-to-diagnose conditions. For this case, doctors recalled an episode of the then-recently-ended Fox TV series, House, a show in which the fictional character Dr. Gregory House solves some of the ... Read More

FDA opens investigation into heart failure risk with diabetes drugs Onglyza, Kombiglyze

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The Food and Drug Administration (FDA) has opened an investigation into the safety of the type 2 diabetes drug saxagliptin after a recent study published in the New England Journal of Medicine (NEJM), reported an increased rate of hospitalizations for heart failure in patients taking the drug. Heart failure occurs when the heart does not efficiently pump blood throughout the body. It can lead to more serious and life threatening problems. Saxagliptin is sold in the United States under the brand names Onglyza and Kombiglyze XR. Patients currently taking saxagliptin should talk with their health care providers about any questions ... Read More

Ariad Pharmaceuticals adds serious blood clot, heart failure risks to label of leukemia drug

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Ariad Pharmaceuticals is re-launching its leukemia drug Iclusig (ponatinib) with new warnings about potential blood clots and the risk of heart failure. The Food and Drug Administration (FDA) ceased sales and promotion of the drug until the drug company addressed safety concerns including the danger of life-threatening blood clots associated with the medication. Iclusig is a treatment for two rare types of leukemia, chronic myeloid leukemia and acute myeloid leukemia. About 5,000 people are diagnosed with the chronic variety of the disease each year. Iclusig was approved by the FDA in late 2012 under the condition that it carry a ... Read More

Testosterone treatment linked to increased risk of heart attacks, strokes, death

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Aggressive marketing campaigns by drug companies peddling testosterone treatments has resulted in an increasing number of men asking their doctors if they are a candidate for testosterone therapy. Low levels of testosterone, or “Low T” as the drug companies have dubbed it, can be blamed for a variety of symptoms from fatigue and low libido to muscle weakness and weight gain. But testosterone supplementation may not be the wonder therapy marketers are claiming it to be. Recent studies show that men who take the drugs are 30 percent more likely to have a heart attack, stroke, or die during a ... Read More

Diabetes drugs may not increase heart problems but could pose cancer risk

Actos (pioglitazone) Type 2 diabetes medication

Studies involving different type 2 diabetes drugs show no evidence that the medications cause heart attacks and strokes, however they do not improve cardiovascular outcomes in patients either. Some medications also pose cancer risks. The first study compared the drug saxagliptin, marketed in the United States as Onglyza, with a placebo in patients who had type 2 diabetes and were considered at high risk for a cardiovascular event. Another study pitted the drug alogliptin, marketed as Nesina, against placebo. Researchers recorded incidences of cardiovascular death, heart attack or ischemic stroke as well as hospitalizations for unstable angina, coronary revascularization or ... Read More

Some type 2 diabetes medications linked to increased risk of heart failure

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New studies suggest two type 2 diabetes drugs do not increase the risk of heart attack, but may increase the risk of heart failure. A heart attack occurs when blood flow to part of the heart is blocked for a long enough time to cause damage or death to part of the heart muscle. Heart failure is a condition in which the heart cannot pump enough blood to the rest of the body. Both conditions can be deadly. Cardiovascular risks with diabetes medications have made headlines in recent years since the blockbuster diabetes drug Avandia was linked to fatal heart ... Read More

For-profit dialysis clinics use more costly and dangerous drugs

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For-profit dialysis kidney centers use more of an expensive and dangerous class of drugs than nonprofit clinics, according to a report published this week in JAMA Internal Medicine. The drugs are known as erythropoiesis-stimulation agents (ESAs) such as Amgen’s Epogen. They are designed to raise levels of hemoglobin, a protein in red blood cells that delivers oxygen. The drugs have come under scrutiny in recent years because critics say they are overused and have been linked to a greater risk for blood clots, heart attacks, strokes, heart failure and death. The drugs carry a black box warning but for-profit dialysis clinics ... Read More

Actos, Avandia use with insulin products may increase risk for heart failure

Actos (pioglitazone) Type 2 diabetes medication

Several insulin products have updated labels warning that using them with a class of type 2 diabetes drugs known as TZDs (thiazolidinediones) increases the risk for heart failure. TZDs include Avandia (rosiglitazone) and Actos (pioglitazone). The labels for Novolin N, Novolin 70/30, Humulin 70/30, Humulin N NPH, and Humulin R, include changes to the patient packet insert for patients to tell their health care provider of other medications they are taking, in particular if they are taking TZDs. “Taking … TZDs with this medicine may cause heart failure in some people. This can happen even if you have never had ... Read More