Sildenafil, the active ingredient in Viagra, a phosphodiesterase-5 inhibitor (PDE5 inhibitor), is not only an erectile dysfunction drug. It is also approved to treat pulmonary artery hypertension, a complication that can worsen the prognosis for patients who have heart failure with preserved ejection fraction (HFpEF), also referred to as diastolic heart failure. Approximately half of people with heart failure have HFpEF. Researchers from The Wright Center for Graduate Medical Education, Scranton, Pennsylvania, recently conducted a meta-analysis to determine the efficacy of sildenafil specifically on the hemodynamic parameters in patients with HFpEF. They identified only four randomized controlled studies with a ... Read More
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