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heartburn medication 13 articles

Heartburn drugs linked to persistent diarrhea

There is more bad news about a type of heartburn medication known as Proton Pump Inhibitors, or PPIs. Last week the British Medical Journal published a study that suggested the drugs put older women at greater risk for hip fractures. Now the Food and Drug Administration (FDA) is alerting doctors and patients that the medicine has been associated with Clostridium Difficile-Associated Diarrhea (CDAD), a persistent type of diarrhea that may develop into more serious intestinal conditions. PPIs include both over-the-counter and prescription drugs including AcipHex (rabeprazole sodium), Dexilant (dexlansopazole), Nexium (esomeprazole magnesium), Omeprazole (omeprazole) OTC, Prevacid (lansoprazole), OTC Prevacid 24 ... Read More

Lesser expensive generic drugs soon available, but are they safe?

The patents for several of the best-selling prescription medications will be expiring over the next two years, paving the way for drug companies to manufacture and sell less expensive generic versions of the drugs. Among the medications that will likely be matched by a generic competitor are the cholesterol-lowering Lipitor and the blood thinner Plavix. On average, generic drugs cost as much as 20 to 80 percent less than their brand-name equivalents. Generic drugs are what the Food and Drug Administration calls “copies of brand name drugs that have exactly the same dose, intended use, side effects, route of administration, ... Read More

Metozolv label has new tardive dyskinesia warning

The new chewable heartburn medication Metozolv, an orally disintegrating version of Reglan (metoclopramide), has added a warning to its label alerting users of a risk of the serious movement disorder Tardive Dyskinesia with long-term use of the drug. The change to the drug’s safety label was approved by the Food and Drug Administration (FDA) and announced this month. The updated information to the drug’s WARNINGS section reinforces the Boxed Warning that was added to all metoclopramide-containing drugs in June 2009. The new warning states, “Treatment with metoclopramide can cause Tardive Dyskinesia (TD), a potentially irreversible and disfiguring disorder characterized by ... Read More

Heartburn drugs before pregnancy may increase risk for birth defects

Women who use heartburn medication during pregnancy should not be overly concerned about the drugs causing birth defects, but using the drugs before they become pregnant may cause problems for the unborn child, according to a new study from Denmark published in the New England Journal of Medicine. The study looked at nearly 841,000 births registered with national databases from 1996 to 2008. In about 5,000 cases, the mothers had taken PPIs at some point during the four weeks prior to pregnancy through their first trimester. Overall, 3.4 percent of the babies whose mothers took PPIs had a major birth ... Read More

Restless leg syndrome turns out to be movement disorder caused by Reglan

PHOENIX, ARIZONA – Ron, a musician and artist, was having trouble sleeping. His legs would move involuntarily back and forth under the sheets. At first, both Ron and his doctors thought he suffered from restless leg syndrome. But after a battery of tests conducted by neurologists, and a review of his medical history and medications, doctors determined that Ron suffered from a Parkinson’s-like condition known as Tardive Dyskinesia. They say it was caused by the heartburn medication Reglan. Reglan, also known by the generic metoclopramide, is a prescription medication used to treat severe heartburn, acid reflux, gastroparesis and other gastrointestinal ... Read More

People feared link between Reglan and suicide 20 years ago

In 1992, a woman wrote to the People’s Pharmacy, a syndicated column in her local newspaper by King Features, asking if her father’s heartburn medication Reglan (metoclopramide) may have led to his suicide. “Looking back, mother started noticing gradual changes in his behavior after his doctor prescribed Reglan for heartburn associated with a hiatal hernia,” she wrote. “We have done some research and found that this drug can indeed cause depression, confusion and even suicide. We were unaware of this side effect when Daddy was taking Reglan. “Why don’t doctors and pharmacists warn patients about this deadly reaction?” she asked. ... Read More

GERD sufferers sought for study on investigational heartburn treatment

Researchers in Sacramento, Calif., are looking for people who still experience troublesome symptoms of gastroesophageal reflux disease (GERD) even while taking heartburn medication, to participate in a study to evaluate an investigational heartburn treatment. Symptoms of GERD include heartburn, or a burning sensation under the breastbone, burning in the back of the throat due to regurgitation of stomach acid, nausea and vomiting. If left untreated, GERD can result in painful inflammation or ulcers in the esophagus, scar tissue in the esophagus, Barrett’s esophagus, cough and asthma, inflammation and infection in the lungs, inflammation of the throat and larynx, and even ... Read More

Using Reglan can make you depressed

You can’t turn on the TV these days without hearing that the heartburn medication Reglan, also known by the generic name metoclopramide, has been linked to the serious involuntary movement disorder, Tardive Dyskinesia. But the drug also carries another serious warning – it can cause depression and suicidal thoughts. Reglan was approved by the Food and Drug Administration (FDA) for the treatment of gastrointestinal conditions such as chronic heartburn, severe acid reflux or GERD, nausea, and gastroparesis. One year ago, after numerous reports of people using Reglan developed the often permanent and debilitating movement disorder, the FDA placed a black ... Read More

Reglan (metoclopramide) jury trial to begin next week

An Atlanta woman is suing Pliva, Inc., makers of the prescription heartburn medication metoclopramide, alleging that the drug company failed to adequately warn physicians of the long-term risks involved with taking metoclopramide. Susan Swicegood says metoclopramide caused her to suffer from a debilitating neurological disorder known as Tardive Dyskinesia, which involves involuntary muscular movements. The lawsuit was filed in the United States District Court, Northern District of Georgia, Atlanta Division, and will be heard by a jury next week. According to the complaint, Swicegood was prescribed 10 mg Reglan to be taken four times daily. Reglan is the brand name ... Read More

Less common symptoms of GERD can make diagnosis difficult

Gastroesophageal reflux disease, or GERD, affects as many as 40 percent of the population. The nagging symptoms of frequent heartburn, upset stomach and an acid taste in the back of the throat can help identify the condition. But some less common symptoms can make the diagnosis more difficult to pinpoint. “I recently met a lady visiting from Iran. She has been coughing for seven years. She had seen numerous physicians and had been tested extensively in Iran. She had no word for heartburn although she described, through a translator, ‘a volcano going off in my chest,’” writes Dr. Kurt Barrett ... Read More