Tagged Articles

heartburn treatment 8 articles

GERD sufferers sought for study on investigational heartburn treatment

Researchers in Sacramento, Calif., are looking for people who still experience troublesome symptoms of gastroesophageal reflux disease (GERD) even while taking heartburn medication, to participate in a study to evaluate an investigational heartburn treatment. Symptoms of GERD include heartburn, or a burning sensation under the breastbone, burning in the back of the throat due to regurgitation of stomach acid, nausea and vomiting. If left untreated, GERD can result in painful inflammation or ulcers in the esophagus, scar tissue in the esophagus, Barrett’s esophagus, cough and asthma, inflammation and infection in the lungs, inflammation of the throat and larynx, and even ... Read More

Forum discusses side effects of heartburn drug Reglan

Wendy from Oklahoma sought advice from fellow gastroparesis sufferers on Inspire.com’s group forum after her doctor recommended she take Reglan (metoclopramide) to treat symptoms of her condition. Gastropareses causes pain and nausea from slow emptying of the stomach contents. Wendy was concerned, she said, because “I read (Reglan) was the leading prescription cause for tardive dyskinesia,” a debilitating involuntary movement disorder similar to Parkinson’s. The numerous responses tell the same story. “My experience with Reglan was absolutely frightening,” says SoCal. “I developed severe Parkinson’s-like tremors and anxiety. And, I don’t even have a history of anxiety. I stopped the drug ... Read More

Drugs that block dopamine receptors can cause Tardive Dyskinesia

An estimated 250,000 to 400,000 people in the United States have Tardive Dyskinesia, a disfiguring and debilitating involuntary movement disorder involving symptoms such as lip smacking, tongue thrusting and protruding, eye blinking and bulging, head jerking, facial grimacing, and puckering and pulsing of the lips. The muscle spasms can become painful and embarrassing and often are permanent. But what is most disturbing is that in many cases, the condition could have been prevented. Tardive Dyskinesia is caused by the long-term use of drugs that block dopamine receptors known as dopamine-receptors antagonists or DRAs. Most of the drugs in this category ... Read More

Using Reglan can make you depressed

You can’t turn on the TV these days without hearing that the heartburn medication Reglan, also known by the generic name metoclopramide, has been linked to the serious involuntary movement disorder, Tardive Dyskinesia. But the drug also carries another serious warning – it can cause depression and suicidal thoughts. Reglan was approved by the Food and Drug Administration (FDA) for the treatment of gastrointestinal conditions such as chronic heartburn, severe acid reflux or GERD, nausea, and gastroparesis. One year ago, after numerous reports of people using Reglan developed the often permanent and debilitating movement disorder, the FDA placed a black ... Read More

More children taking prescription drugs to treat chronic conditions

American children are taking more medications than ever before to treat chronic conditions, according to the 2010 Medco Drug Trend Report, raising the question, “How safe are these drugs for children?” The drug trend report looked at prescription drug spending growth between 2001 and 2009 and found that prescription drug use among children has grown four times higher than the overall population. More than one in four insured kids and nearly 30 percent of adolescents (10-19 years of age) took at least one prescription medication to treat chronic conditions. The most substantial increases were seen in the use of antipsychotic, ... Read More

Alzheimer’s drug may treat Barrett’s esophagus, esophageal cancer

A team of researchers renowned for their work in colon cancer believe they may have found a better treatment for Barrett’s esophagus and esophageal cancer based on findings from their colon cancer research, according to Science Daily. Cancer of the esophagus is one of the 10 most common cancers, yet there is no good treatment for the disease. Most people who have been diagnosed with esophageal cancer also have a long history of heartburn. Heartburn occurs when toxic acid from the stomach splashes up into the esophagus. Over time, if left untreated, this constant bathing of stomach acid can damage ... Read More

New heartburn medication meets expectations in drug trial

Swiss biotech group Addex Pharmaceuticals announced that its lead drug candidate met expectations in a mid-stage clinical trial in heartburn, setting the company up for a lucrative partnership with a bigger drug maker that would provide much-needed funds for the startup company. In a Phase IIb trial, Addex’s ADX10059 increased performed well in the treatment of gastroesophageal reflux disease (GERD). The four-week trial, which comprised 103 patients, showed ADX10059 significantly increased the number of symptom-free days for patients that took the drug compared to patients on a placebo. Patients involved in the trial had previously responded well to a group ... Read More

New study may lead to different treatments for GERD

Findings from a new study on the causes of gastroesophageal reflux disease (GERD) may lead to new way of treating the condition. According to a team of researchers from the University of Texas Southwestern Medical Center, GERD, which causes painful chest pain and heartburn, may be caused by immune system cells causing inflammation. The study showed that gastroesophageal reflux in rats causes tissue in the esophagus to release immune chemicals called cytokines. Those cytokines attract inflammatory cells that cause the uncomfortable symptoms associated with heartburn and GERD. GERD is a condition thought to be the result of an acid burn ... Read More