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hepatitis B 4 articles

Long-term Hepatitis B treatment linked to cervical, colorectal cancer

Long-term use of oral nucleos(t)ide analogues for the treatment of chronic hepatitis B virus (HBV) may increase the risk of colorectal and cervical cancer, according to new study presented at The International Liver Congress in Barcelona, Spain. Prolonged treatment with nucleos(t)ide analogues to prevent the virus from reproducing are recommended in some patients with chronic HBV, but questions have been raised about the safety of long-term use. This prompted researchers with the Department of Medicine & Therapeutics Academic at the Chinese University of Hong Kong to investigate the risks. The study involved more than 45,000 patients with chronic HBV. Of ... Read More

Hepatitis B vaccine recalled due to sterility issues

Vials of the hepatitis B vaccine RECOMBIVAX HB are being recalled by the manufacturer because a limited number of the vials in the lot may crack, the Food and Drug Administration (FDA) announced. If a crack occurs, the integrity of the vial and the sterility of any product remaining in the vial could not be assured. Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., issued the recall for Lot Number J001183 of RECOMBIVAX HB (Recombinant) Adult Formulation. The product was distributed only in the United States between March 12, 2013, and May 2, 2013. The company says ... Read More

Labels on TNFa blockers get stronger warning

The black box warning for a class of immunosuppressant drugs known as Tumor Necrosis Factor-alpha (TNFa) blockers is being updated to include the risk of potentially deadly infections from two bacterial pathogens, Legionella and Listeria. TNFa blockers are biologic products that include Remicade (infliximab), Enbrel (etanercept), Humira (adalimumab), Cimzia (certolizumab pegol), and Simponi (golmumab). TNFa blockers are drugs used to treat Crohn’s disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, and/or juvenile idiopathic arthritis. Since TNFs blockers are immunosuprresants, patients who take these drugs are at increased risk of serious, including fatal, infections. These infections can involve ... Read More

Merck vaccines contaminated with charred bits of shrink wrap

Charred bits of plastic shrink wrap have been found in vials of vaccines manufactured by Merck & Co, adding to mounting quality control concerns at the company’s West Point facility in Philadelphia. The contaminated shots include those that protect against the human papillomavirus (Gardasil), shingles (Zostavax), measles/mumps rebella (MMR II), pneumococcal disease (Pneumovax), and chicken pox (Varivax). An April 2011 report by the Food and Drug Administration (FDA) Department of Health and Human Services found 12 reports of charred shrink wrap particles found in licensed biological products, eight of which came from consumer complaints and four from a retention sample ... Read More