Tagged Articles

hot flashes 18 articles

FDA approves Pfizer’s new hormone treatment for hot flashes, prevention of osteoporosis

The Food and Drug Administration (FDA) has approved Duavee, Pfizer’s new hormone treatment for menopause-related hot flashes in women who have not had a hysterectomy, and to prevent osteoporosis in post-menopausal women. Duavee is the first FDA-approved drug that combines a mixture of estrogens with another compound, bazedoxifene, which acts like estrogen to protect bone density. The FDA rejected bazedoxifene as an osteoporosis treatment in 2009 after numerous delays based on concerns that the drug could increase the risk for strokes and blood clots. Duavee enters a profitable market that already includes Hisamitsu Pharmaceutical Co.’s Brisdelle and Eli Lilly & ... Read More

FDA panel rejects non-hormonal menopause treatment

An experimental non-hormonal treatment for menopause was rejected by a Food and Drug Administration advisory panel this week because the group found risks associated with the drug were greater than any benefit it offered. Drug maker Depomed submitted for approval Seflsa, known generically as gabapentin, a medication that has long been used to treat pain and seizures. It is also prescribed off-label by doctors to treat menopause symptoms. Depomed asked the FDA to approve this use, which would allow the company to market it as a menopause treatment. The panel’s decision to vote against approving Seflsa is based on studies that ... Read More

Lexapro may be effective in treating symptoms of menopause

The antidepressant escitalopram, known by the brand name Lexapro, was effective in decreasing hot flash frequency and severity in menopausal women, according to a small clinical trial. Lexapro is in a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is approved to treat depression and generalized anxiety disorder, and excessive worry and tension that lasts for 6 months or longer. Other brand-name antidepressants in the SSRI class include Paxil, Zoloft, Celexa, and Prozac. The study was conduced in 2009 and has not resulted in the drug’s maker seeking approval for the new indication. However, some doctors prescribe ... Read More

Poise brand launches line of products to help with menopause symptoms

Kimberly-Clark, makers of Poise pads for incontinence, is launching a new line of products for women who are or will soon go through menopause. The line includes lubricant for vaginal dryness, panty freshener sticks and feminine wash for odor, and cooling towelettes and roll-on gel for women having hot flashes. The Poise brand was first launched in 1992, and sales of Poise products have grown steadily over the years. In 2009, the company coined the phrase “light bladder leakage,” or LBL, to avoid the negative stigma associated with the word “incontinence.” Kimberly-Clark also hired actress Kirstie Alley to front its ... Read More

Estrogen patches carry new warnings for cancer, cardiovascular disease, dementia

Estraderm transdermal system used to treat symptoms of menopause has a new black box warning added to its safety label. The new label warns of endometrial cancer, cardiovascular disorders, breast cancer, and probable dementia. Black box warnings, or boxed warnings, are the strongest warning that the Food and Drug Administration (FDA) requires, and signifies that medical studies indicate that the drug carries a significant risk of serious or even life-threatening adverse effects. The Estraderm (estradiol) transdermal system is a patch that is placed on the trunk of the body to deliver the hormone estrogen to treat menopause symptoms including hot flashes, vaginal dryness ... Read More

Study finds HRT breast cancers are more likely to be advanced, deadly

The evidence weighing the benefits and risks of hormone replacement therapy (HRT) in menopausal and postmenopausal women continues to tip toward the same conclusion – that taking HRT is dangerous. HRT was once heralded as a cure-all for problematic symptoms of menopause, including hot flashes, sleeping difficulties, mood swings and vaginal dryness. It was also given the added benefit of protecting women against heart disease and osteoporosis. However, opinion quickly changed in 2002, after a large study of postmenopausal women found that HRT that combined the hormones estrogen and progesterone increased a woman’s risk for breast cancer by about one extra ... Read More

Herbal alternative to HRT denied FDA approval

An herbal remedy for menopause symptoms marketed in Japan failed to show benefits among American women, according to a recent study published in the journal Menopause. The pill, known as TU-025, combines cinnamon bark, peach pits and several other botanicals, and is regulated as a prescription drug in Japan. It is commonly used by Japanese gynecologists to treat hot flashes in menopausal women. The drug’s maker, Tokyo-based Tsumura & Company, helped fund a study to see if the benefits would also be seen in American women. The consensus was that if it proved beneficial, the herb could offer a safer ... Read More

Dr. Oz warns post-menopausal guest to stay away from HRT

How important is it for a post-menopausal woman to take hormone replacement therapy (HRT)? Audience member Rosemarie posed the question to Dr. Oz, the popular television doctor. Rosemarie says she became post-menopausal three years ago and she has never taken HRT. Hormone replacement therapy was designed to boost hormone levels in menopausal and post-menopausal women and help them deal with symptoms such as irritability, night sweats, hot flashes, vaginal dryness and sleeplessness. If you asked drug companies – especially 20 years ago when HRT was widely prescribed – they would rattle off a laundry list of extra benefits ranging from ... Read More

More studies help women make educated decisions about HRT

The more than 2 million baby-boomer women who are approaching menopause may find themselves in a precarious position when it comes to handling hot flashes and mood swings. Should they risk the threat of breast cancer from use of hormone replacement therapy, or simply suffer through the agonizing symptoms? According to Forbes, new and detailed research offers women the opportunity to make a more educated decision. Last February, the New England Journal of Medicine concluded that HRT was in fact linked to a surge of breast cancer cases and that women who took a combination of progestin and estrogen for ... Read More

Estrogen receptor-positive cancer easier to treat, study says

Hormone replacement therapy (HRT) and its link to breast cancer and other serious conditions continue to make headlines. This week, U.S. News & World Report announced that women who take HRT and then get breast cancer are at lower risk of dying from their disease, according to a new study by the University of California-Irvine. Years ago, HRT was the method-of-choice for most women to combat annoying menopausal symptoms such as hot flashes, moodiness, night sweats and decreased sexual desire. The therapy also was thought to offer other benefits, such as a lowered risk of heart disease and breast cancer. ... Read More