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HRT 58 articles

Testosterone treatments can double, triple heart attack risk in men

Men who use testosterone replacement therapies have a “substantial” risk of having a heart attack, says Francisco Lopez-Jimenez, a Mayo Clinic researcher involved in a new study published in the journal PLOS One. The report is one of a series of new studies looking into the long-term effects of testosterone therapy, a treatment that has increased dramatically in popularity in recent years. The study involving 56,000 men found that older men using testosterone supplements were twice as likely to have a heart attack, and younger men with heart disease were nearly three times as likely to have heart problems. “That’s the ... Read More

FDA approves Pfizer’s new hormone treatment for hot flashes, prevention of osteoporosis

The Food and Drug Administration (FDA) has approved Duavee, Pfizer’s new hormone treatment for menopause-related hot flashes in women who have not had a hysterectomy, and to prevent osteoporosis in post-menopausal women. Duavee is the first FDA-approved drug that combines a mixture of estrogens with another compound, bazedoxifene, which acts like estrogen to protect bone density. The FDA rejected bazedoxifene as an osteoporosis treatment in 2009 after numerous delays based on concerns that the drug could increase the risk for strokes and blood clots. Duavee enters a profitable market that already includes Hisamitsu Pharmaceutical Co.’s Brisdelle and Eli Lilly & ... Read More

FDA panel rejects non-hormonal menopause treatment

An experimental non-hormonal treatment for menopause was rejected by a Food and Drug Administration advisory panel this week because the group found risks associated with the drug were greater than any benefit it offered. Drug maker Depomed submitted for approval Seflsa, known generically as gabapentin, a medication that has long been used to treat pain and seizures. It is also prescribed off-label by doctors to treat menopause symptoms. Depomed asked the FDA to approve this use, which would allow the company to market it as a menopause treatment. The panel’s decision to vote against approving Seflsa is based on studies that ... Read More

Study suggests timing of HRT affects dementia risk

How soon after menopause a woman uses hormone replacement therapy (HRT) may determine her risk for developing dementia, a new study published online in the journal Neurology suggests. The numerous studies conducted on the effects of HRT in women have come to different conclusions about whether the menopause treatment lowers or raises a woman’s risk for Alzheimer’s disease and dementia. Observational studies, or those that follow a group over a period of time, show a reduced risk of dementia in women who use HRT, whereas clinical trials, which test the effects of a drug against placebo, show an increased risk. ... Read More

Drug companies spend millions to promote testosterone gels

Drug companies peddling testosterone replacement products have their eyes on older men. Advertisements promoting testosterone gels by firms such as Abbott and Eli Lilly have risen more than 170 percent in the past three years to more than $14 million in 2011, according to advertising tracker Kanter Media. Those efforts have resulted in a 90 percent increase in prescriptions for the hormone during the past five years, which translates to nearly $2 billion in global sales. Baby boomers are the target of these campaigns, which ask men if they suffer from a decrease in libido, weight gain or fatigue. The ... Read More

Jurors award Utah woman $5.1 million in HRT-breast-cancer case

A Utah woman was awarded $5.1 million in compensatory damages by a federal jury that found hormone replacement therapy (HRT) drugs caused her to develop breast cancer, and that the drug companies who developed and marketed HRT were negligent because they failed to adequately warn users of the risks associated with the menopause treatment. The plaintiff, 73-year-old Toshiko Okunda, filed her lawsuit in 2004. She had a hysterectomy in 1985 at the age of 47, and because of severe menopausal symptoms, was prescribed over the next 17 years various doses and combinations of HRT including Premarin, Provera and Prempro. In ... Read More

Poise brand launches line of products to help with menopause symptoms

Kimberly-Clark, makers of Poise pads for incontinence, is launching a new line of products for women who are or will soon go through menopause. The line includes lubricant for vaginal dryness, panty freshener sticks and feminine wash for odor, and cooling towelettes and roll-on gel for women having hot flashes. The Poise brand was first launched in 1992, and sales of Poise products have grown steadily over the years. In 2009, the company coined the phrase “light bladder leakage,” or LBL, to avoid the negative stigma associated with the word “incontinence.” Kimberly-Clark also hired actress Kirstie Alley to front its ... Read More

Testosterone therapy can relieve symptoms of andropause

An estimated 20 to 30 percent of all men suffer from andropause, the male equivalent to menopause in women. It affects men in their mid 40s and older and carries symptoms such as mood swings, low sex drive and forgetfulness. But it can also lead to more serious problems, including osteoporosis. Just as women have hormone replacement therapy as a menopause treatment option, men have options, too. Testosterone therapy is the standard treatment for men who have been diagnosed with low testosterone levels. Treatments include injections or patches. The most popular treatment is a testosterone gel, which is sold under ... Read More

More men using testosterone treatments to boost libido

Sales of testosterone drugs are skyrocketing in recent years, driving into the billions. And while the drugs help older men feel like teenagers again, some types of testosterone treatments are causing disturbing side effects for others accidentally exposed. An estimated 13.8 million men older than 45 in the United States have low levels of testosterone, which can lead to a loss in libido, a decrease in bone and muscle mass, and depression. More and more men are turning to hormone therapies to help them feel like their former selves. And they are being driven there by marketing campaigns, such as ... Read More

Birth control shot Depo-Provera linked to breast cancer

Women who use the contraceptive Depo-Provera for at least a year have double the chance of developing breast cancer; however, that risk goes back to that of non-users a few months after the injections are discontinued, according to a new study. Depo-Provera is an injectable contraceptive given once every three months. It is desirable to some women because it is effective, more convenient than a once-daily pill, and is relatively inexpensive. The new study on Depo-Provera, conducted by researchers at the Fred Hutchinson Cancer Research Center, is the first of its kind in the United States specifically designed to evaluate ... Read More