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insulin 24 articles

Drug company sees promise in trials of first oral insulin pill

An Israeli drugmaker is doing something no company has ever done before – developing an insulin that can be taken by mouth. Clinical trials using the drug in type 2 diabetic patients are currently underway and early results are promising. Insulin therapy is important for regulating blood sugar levels in both type 1 and type 2 diabetics. Those who require insulin take it by injection –usually from a shot or pump that injects the insulin into the fat under the skin so it can get into the blood. Insulin has not been previously been available in an oral pill because ... Read More

Medtronic issues urgent medical device safety notice regarding infusion pumps

Medtronic has issued an urgent medical device safety notification to patients and health care providers regarding its Paradigm Infusion Set Connectors, which connect to Medtronic Paradigm infusion sets used to administer insulin to diabetic patients in order to maintain blood glucose levels. Vents can become blocked if insulin or other fluids come in contact with the inside of the connector on the Medtronic Paradigm infusion sets. If the pump’s vents are blocked, this can potentially result in too much or too little insulin being delivered, which may cause hypoglycemia or hyperglycemia. In extreme cases, these conditions may cause loss of consciousness or death. According to the safety notification, ... Read More

Actos, Avandia use with insulin products may increase risk for heart failure

Several insulin products have updated labels warning that using them with a class of type 2 diabetes drugs known as TZDs (thiazolidinediones) increases the risk for heart failure. TZDs include Avandia (rosiglitazone) and Actos (pioglitazone). The labels for Novolin N, Novolin 70/30, Humulin 70/30, Humulin N NPH, and Humulin R, include changes to the patient packet insert for patients to tell their health care provider of other medications they are taking, in particular if they are taking TZDs. “Taking … TZDs with this medicine may cause heart failure in some people. This can happen even if you have never had ... Read More

AAP issues first-ever guidelines for type 2 diabetes in children, teens

The American Academy of Pediatrics (AAP) has issued the first guidelines for the management of type 2 diabetes in children and teenagers aged 10 to 18. The guidelines were developed to assist pediatricians and pediatric endocrinologists, who most often are used to dealing with type 1 diabetes. However, the increase in childhood obesity has led to more children being diagnosed with type 2 diabetes – a condition once thought to affect adults only. Now, as many as one in three children diagnosed with diabetes has type 2. It can be difficult to quickly distinguish between type 1 and type 2 diabetes in ... Read More

FDA to review heart risks with new type 2 diabetes drug Tresiba

A Food and Drug Administration (FDA) advisory panel is expected to take a hard look at cardiovascular risks when it considers whether to recommend for approval Novo Nordisk’s type 2 diabetes drug Tresiba. The drug would go head-to-head with Sanofi’s best selling Lantus insulin, which generated more than $5 billion in revenue last year. News of the advisory panel’s concerns sent Novo Nordisk’s stock to its lowest point in more than 14 months, down 2.7 percent to 935.50. The drug company is the world’s largest insulin maker, and some analysts say Tresiba sales could generate as much as $9 billion ... Read More

Paula Deen’s diabetes drug of choice brings in hearty profits

Danish pharmaceutical company Novo Nordisk is rolling in profits, thanks to strong sales of its new diabetes drugs. Novo Nordisk is the world’s largest insulin manufacturer. It also makes non-insulin medications to treat type 2 diabetes including Victoza, a new treatment that is being promoted by Southern celebrity cookbook author Paula Deen. Deen caught a lot of flack when she announced earlier this year that she had been diagnosed three years ago with type 2 diabetes. Deen’s Southern-fried and sugar-filled recipes are prime examples of the kinds of foods that contribute to the country’s growing obesity and diabetes epidemic. But ... Read More

New analysis shows diabetes, diabetes drug Actos, increase risk for bladder cancer

A new analysis of previously completed studies provides more evidence that people with type 2 diabetes have a greater risk of developing bladder cancer, and taking the diabetes drug Actos increases that risk even more. The study, published July 3 in the Canadian Medical Association Journal found that people with type 2 diabetes have a 40 percent increased risk of developing bladder cancer. This risk is believed to be associated with high levels of insulin. Insulin is also a growth hormone, and cancer cells have insulin receptors, which means they can use insulin to grow. Studies on type 2 diabetes ... Read More

Study: Actos, Avandia may increase risk of macular edema

The popular type 2 diabetes drugs Actos and Avandia may increase the risk of eye and vision problems, according to a study published this month in the Archives of Internal Medicine. The study, Association Between Thiazolidinedion Treatment and Risk of Macular Edema Among Patients with Type 2 Diabetes, followed more than 100,000 patients during a 10-year period. Researchers found that participants who used either Actos or Avandia had a two to three times greater risk of developing macular edema. Those who used the drug with insulin had an even greater risk. Macular edema occurs when fluid and protein deposits collect ... Read More

Study shows daily insulin injections do not raise risk for heart attack, stroke, cancer

The safety of diabetes medications has been a concern since the Food and Drug Administration (FDA) issued warnings about cancer and heart attacks associated with the type 2 diabetes drugs Actos and Avandia. For decades, people have wondered if the use of another diabetes medication – insulin – made diabetics more susceptible to cardiovascular disease and cancer. But, a new study offers some peace of mind, indicating long-term, daily injections of insulin do not appear to increase the risk for heart attacks, strokes, or cancer in people with type 2 diabetes or pre-diabetes. The new international study, led by Canadian researchers, ... Read More

Kids with type 2 diabetes have limited treatment options

The rising number of kids being diagnosed with type 2 diabetes has created new challenges on how to manage the “adult-onset” disease in young people, according to concerns raised at a recent meeting of pediatricians in Boston. The staggering increase in type 2 diabetes is a result of increased childhood obesity. About half the new cases of diabetes in teenagers these days is for the type 2 “adult” variety, compared to just three percent decades ago. How to treat these children is what researchers call discouraging. Researchers studied about 700 children over the course of four years. They found that ... Read More