Tagged Articles

Invokana and Invokamet 43 articles

Doctors should educate patients taking Invokana about ketoacidosis symptoms

Less than a year after the U.S. Food and Drug Administration (FDA) warned of ketoacidosis risk in patients taking a class of type 2 diabetes drugs known as SGLT2 inhibitors, the European Commission issued the same warning. Now drug authorities in both countries are urging health care providers to be vigilant and educate patients about the signs and symptoms of the serious condition. Both groups say SGLT2 inhibitors, which include Invokana and Invokamet, are effective at lowering blood sugar levels in some patients, but there is a risk for developing ketoacidosis. The condition occurs when too many ketones build up ... Read More

AstraZeneca diabetes drug cocktail rejected by FDA

The Food and Drug Administration (FDA) rejected a fixed-dose drug cocktail from AstraZeneca to treat type 2 diabetes, saying not enough clinical data was provided with the drug’s application. AstraZeneca took the news hard, saying the setback would push back the drug’s launch date by a year or two, depending on whether new clinical trials would need to be conducted. The drug is a combination of two already FDA-approved drugs to treat type 2 diabetes – saxagliptin and dapagliflozin. Saxagliptin, which is sold under the brand name Onglyza, is a class of diabetes drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, ... Read More

Updated labels of Invokana, Invokamet include bone fracture, fall warnings

The Food and Drug Administration (FDA) has approved updated safety labels for the type 2 diabetes drugs Invokana and Invokamet that include stronger warnings regarding bone fracture risk, especially among people with decreased bone mineral density. The new warnings are listed under the WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS sections of the drug’s label. Invokana and Invokamet contain the active drug ingredient canaliflozin, and were approved by the FDA in 2013 and 2014, respectively. Invokamet also includes the diabetes drug metformin. The drugs are in a class of type 2 diabetes medications known as SGLT2 inhibitors. Other drugs in this class ... Read More