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kidney disease 50 articles

Study warns against PPI use for people with cystic fibrosis

Researchers at the University of Florida have linked acid reducing proton pump inhibitors, or PPIs, such as Prevacid, Nexium and Prilosec, to another risk. They are already under fire for links to kidney disease and kidney failure. The manufacturers of these drugs are being sued by many patients with serious kidney injuries who allege “negligence, design defect, failure to warn, fraudulent concealment, warranty claims and loss of consortium” as the cause of action against defendants. The popular drugs have also been linked to increased risk for gastric cancer, stroke, heart attack, dementia, C. difficile infections, and bone fractures. The new ... Read More

Tips for managing heartburn symptoms this Thanksgiving

The week of Thanksgiving is the 18th Annual GERD Awareness Week. Gastroesophageal reflux disease, or GERD, is very common, affecting millions of Americans. Its most common symptom is heartburn, specifically heartburn that occurs multiple times a week, is severe enough to wake a person from sleep, or occasional heartburn that is associated with difficulty swallowing or has persisted for five or more years. Another common symptom is acid regurgitation. Other less common symptoms include belching, difficulty or pain when swallowing, sudden excess of saliva, dysphagia (the sensation of food sticking in the esophagus), chronic sore throat, laryngitis, inflammation of the gums, ... Read More

Study links PPIs to risk of stroke and heart attack

A study published on Oct. 12, 2017, in Journal of Internal Medicine is linking common acid-reducing drugs to increased risk of strokes and heart attacks. Proton pump inhibitors, or PPIs, such as Prevacid, Nexium and Prilosec, are available both by prescription and over-the-counter and are taken by millions of Americans to treat ulcers, heartburn and acid reflux. When the researchers presented their preliminary findings last year at an American Heart Association conference, Dr. Thomas Sehested, the study’s lead author and a researcher at the Danish Heart Foundation, commented according to KFOR that, “PPIs have been associated with unhealthy vascular function, ... Read More

Call to deprescribe PPIs intensifies after drugs linked to persistent dermatological reaction

Proton pump inhibitors, or PPIs, used to treat symptoms of heartburn and acid reflux have been linked to side effects such as kidney disease, stomach infections, heart disease, pneumonia, bone fractures, and dementia, and even higher risk of death when compared to other drugs used to treat similar issues. Available both over-the-counter and by prescription, these popular drugs are taken by millions of Americans. PPIs have a reputation for being over-prescribed and used long-term when it is not medically necessary. Health care reformers have long been making efforts to limit PPI overuse and as more and more researchers raise awareness about ... Read More

Intervention works to reduce PPI overuse in hospital setting

Investigators have just published in JAMA Internal Medicine the results of an intervention that was launched in 2015 by fellows and residents at University of Chicago. Their goal was to address and reduce in the hospital setting unnecessary proton pump inhibitor infusions in patients with upper GI bleeding, lowering the cost of the care the patient receives, said Healio. “Unfortunately, PPI infusions may be continued for 72 hours without indication,” investigators wrote. “Reducing the overuse of these infusions is important because, in addition to increasing the length of stay and cost, PPI overuse is associated with various complications.” Some of ... Read More

Study: plant-based diet effective for reflux symptoms, alternative to PPIs

Medscape reports that a study just published in JAMA Otolaryngology–Head & Neck Surgery suggests that diet could control symptoms of laryngopharyngeal reflux (LPR) more effectively than proton pump inhibitors (PPIs). Guidelines for those suffering from LPR contradict, with some recommending PPI therapy and others saying patients with the condition who lack typical symptoms should avoid PPIs. Robert T. Kavitt, MD, MPH, from the University of Chicago, Illinois, in an editorial in JAMA Otolaryngology accompanying the study’s results, says, “Given the conflicting approach of society guidelines, as well as limited data regarding the role of medical therapy in the treatment of ... Read More

Doctor recommends discontinuing PPIs

In a column published in KPC News Dr. Terry Gaff said of popular acid-reducing proton pump inhibitors, or PPIs, such as Prevacid, Nexium and Prilosec: “Having been involved in medicine for many years, I remember when these drugs became available to help patients with stomach ulcers and gastroesophageal reflux disease (GERD). Back then, we were told to use these drugs with caution and for a very limited time to help avoid possible side effects. “Since then, PPIs have become among the most commonly used drugs, and their use has often become long term. Up to 55 percent of primary care ... Read More

Researchers say PPIs are being prescribed off-label to infants

New Zealand researchers are very concerned to find that although proton pump inhibitors (PPIs) are not approved to treat children younger than 1 year old, clinical trials have not found them to be more effective than placebos in infants, and the drugs carry risks of side-effects, their off-label prescription to this age group is common in the country. Previously the University of Otago researchers studied PPI use and showed that the popular acid reducing drugs increase the risk of developing interstitial nephritis, a kidney disease usually caused by an allergic reaction to drugs that can cause permanent kidney damage. PPIs ... Read More

National Kidney Month: Time to learn about kidneys and kidney disease

March is National Kidney Month, a great time to learn more about kidneys and kidney disease, the ninth leading cause of death in the U.S. The National Kidney Foundation has created a graphic full of useful information, which includes six ways kidneys keep you healthy, eight problems kidney disease can cause, four risk factors and seven symptoms of kidney disease, and two tests you can take to check your kidney health. Kidneys filter wastes from 200 liters of blood a day, help regulate both fluid levels and blood pressure, keep blood minerals in balance and direct red blood cell production. Twenty-six million American adults ... Read More

70 percent increased risk of gastro hospitalization for PPI users, study says

Australian National University researchers have found that people taking acid-reducing drugs proton pump inhibitors, or PPIs, have a 70 percent increased risk of being hospitalized for infectious gastroenteritis.They reported results that these hospitalizations accounted for just over 13 million lost days of work in Australia each year. Researchers analyzed information from patients older than 45 suffering from gastroenteritis. “The elderly and those with chronic bowel problems are most at risk,” lead author Yingxi Chen said according to ABC News. “These patients should be having a conversation with their doctor to ensure that they are on right dose and that these ... Read More