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Low T 116 articles

Repros enrolls men to test new topical testosterone treatment Androxal

Repros Therapeutics Inc. announced it has completed enrollment for one of two clinical trials pitting its topical testosterone gel alternative Androxal against other topical testosterone products currently on the market. Each trial will include 120 men, who will be divided into groups of 40 for three parallel study arms to test Androxal against an already marketed testosterone gel and a placebo. Studies will run for 17 weeks, which includes 16 weeks of dosing and one week of follow-up to gather information for the conclusion. Repros sought men who were at least 60 years of age who exhibited a normal sperm count ... Read More

Study: Low T contributes to more satisfying relationships

Low testosterone levels in men have been blamed for a variety of symptoms – from low sex drive and mood swings to weight gain and muscle loss. But a new study shows that low testosterone has its benefits. It may actually contribute to more romantic and satisfying relationships. “The assumption is generally that high testosterone is good for sexual relationships,” says Robin Edelstein, associate professor of psychology with the University of Michigan. Edelstein and her team set out to put that notion to the test. They surveyed 39 heterosexual couples between the ages of 18 and 39 who were in relationships ... Read More

Doctor raises red flags regarding heart risks with testosterone therapy

Testosterone replacement therapy may sound attractive with ads promising to build muscle mass and boost libido, but Low T therapy may not be all that it’s cracked up to be, warns Dr. Joe Littlejohn, a urologist at Orlando Health. It could be deadly. If you listen to the advertisements from drug companies pushing testosterone products, such as AndroGel, Testim and Axiron, the therapy can help men feel decades younger. Though testosterone levels drop naturally as men age, these supplements can help men turn back the clock. What’s not to love? New research, however, has raised some serious red flags that ... Read More

European drug regulators investigating heart attack, stroke, death risks with testosterone therapies

The European Medicines Agency (EMA) is reviewing the safety of testosterone therapy after studies showed the treatment increases the risk of strokes, heart attacks and death. The announcement comes three months after the U.S. Food and Drug Administration (FDA) launched a similar investigation into the drugs. Testosterone supplements are prescription medications given to men with low testosterone levels. The drugs are used to treat symptoms of “Low T” such as fatigue, muscle loss, weight gain and low sex drive. The drugs are available in capsules, implants for under the skin, patches or topical gels. Brand names include Testim, Androgel and Axiron. ... Read More

Group with drug maker ties pushes for retraction of paper linking testosterone therapy to heart problems

The Androgen Study Group, a newly formed multidisciplinary group of clinicians and researchers focused on the science of testosterone deficiency in men and its treatment, is calling for the retraction of a paper published in the Journal of the American Medical Association (JAMA) that linked testosterone replacement therapy to an increased risk of heart attacks, strokes and death. In a letter to JAMA editor-in-chief, the group claims that the study the paper was based on was compromised and should be removed from the journal. The paper by Michael Ho, MD, PhD focused on a study that found a higher rate ... Read More

More lawsuits filed against makers of testosterone replacement therapies

Makers of testosterone treatments are being slapped with lawsuits following studies that show use of the products increases the risk of cardiovascular events. The latest lawsuits to be filed name Auxilium Pharmaceuticals and GlaxoSmithKline, makers of Testim, as well as Abbott Laboratories and AbbeVie, makers of AndroGel. A lawsuit filed by Robert Olivetti and his wife Marion allege that Mr. Olivetti’s use of Testim and AndroGel caused him to have a heart attack, which led to a coronary bypass. Edwin Rios and wife Eileen lawsuit claim Mr. Rios’ use of Testim caused his heart attack. The plaintiffs say the drug ... Read More

Philadelphia man claims Testim testosterone treatment gave him a heart attack

A 67-year-old Philadelphia man with no history of cardiovascular problems has filed a lawsuit against the makers of his testosterone replacement product claiming the drug caused him to suffer a heart attack. The lawsuit states that the injury was caused by the “exogenously administered testosterone-containing Testim,” a prescription drug made by Auxilium Pharmaceuticals and GlaxoSmithKline. Edwin Rios had been using Testim for a year when he had the heart attack. Testosterone replacement products are designed to boost the hormone’s levels in men who are experiencing symptoms of low testosterone such as weight gain, mood swings, and low libido. Testim was ... Read More

FDA approves long-lasting injectable testosterone therapy despite protests

The Food and Drug Administration (FDA) has approved a new long-lasting testosterone treatment for men despite protests from consumer watchdog Public Citizen to delay it’s decision until the agency has had a chance to review studies that show testosterone replacement therapy increases the risk of heart attacks, strokes and death. The new treatment, AVEED, made by Endo Pharmaceuticals, is an injection that is administered as a single 3mL (750 mg) intramuscular injection given once at initiation of therapy, at four weeks, and then every 10 weeks thereafter. It will be available as a prescription this month. The drug is intended ... Read More

Public Citizen urges FDA to add warnings of heart attack, stroke, death to testosterone treatments

Consumer advocacy group Public Citizen is petitioning the Food and Drug Administration (FDA) to require manufacturers of testosterone treatments to add black box warnings on the labels about the increased risk of heart attacks, stroke and death in men who use the treatment. Black box warnings are the strongest given by drug regulators and signify that medical studies indicate that a particular drug carries a significant risk of serious or even life-threatening adverse events. Testosterone supplements, including AndroGel, Testim and Axiron, are approved by the FDA to treat hypogonadism, a medical condition in which the testes produce little to no testosterone. ... Read More

Does testosterone therapy pose heart risks for women?

You probably wouldn’t know it from the male-targeted advertisements pushing hormone supplements to boost “Low T,” but testosterone therapy can provide similar benefits for women. The question is, does it also carry the same risk of heart attacks, strokes and death in women as it does for men? Testosterone is considered the male hormone, responsible for the maturation of the testis and prostate as well as the development of sexual characteristics such as increased muscle, bone mass and body hair. In general, adult men have about 7-8 times more testosterone pumping through their bodies than adult females. Estrogen, considered the ... Read More