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Low T 116 articles

New Jersey man blames heart attack on Axiron testosterone treatment

New Jersey resident Patrick Miller was 54 when he started using Axiron, a testosterone replacement product used to treat men who have low levels of the hormone in their blood. A month later, on Oct. 3, 2012, he had a heart attack. Thirteen months later, the Journal of the American Medical Association (JAMA) published a study that found men who used testosterone treatments have a 30 percent increased risk of having a heart attack, stroke or dying. And, in January 2014, the journal PLOS One found a two-fold increased risk of heart attack among older men in the first 90 days ... Read More

Experts: testosterone treatments vastly overprescribed

Nearly 3 percent of American men aged 40 and older – about two million men – received prescriptions for testosterone replacement treatments in 2011 – three times more than a decade earlier, raising concerns that the drugs may be overprescribed. Testosterone therapy is intended for men who suffer from low testosterone levels, a condition known as hypogonadism, caused by damage or disease in their testes or other parts of the endocrine system. This can cause symptoms such as low sex drive, muscle loss, weight gain and fatigue. Testosterone levels typically drop as a man ages. But many middle-aged and older ... Read More

Panel recommends more studies on cardiovascular risks with testosterone drugs

Makers of testosterone replacement drugs should collect data on heart attacks and strokes in men who use their products, and the labels on the treatments should have stronger language to restrict intended uses to reduce over-prescribing, a Food and Drug Administration (FDA) advisory panel recommended. The FDA asked an outside panel of experts to address whether there is a risk of major cardiovascular events such as stroke, heart attack and death in men who used testosterone replacement therapies. The agency also asked the panel whether current evidence still supports the use of the drugs in certain patients. The FDA is ... Read More

Feds want to limit prescribing of testosterone replacement drugs

The indication for testosterone replacement treatments should be scaled back so that fewer men are prescribed them because the drugs do little to counter the signs of aging, a federal advisory panel announced. The group voted 10-1 to recommend that the prescribing language on testosterone supplements be revised to make it clear that the drugs have not been shown to reverse common symptoms of aging such as low libido, muscle loss, weight gain and fatigue. The new wording would limit the drug only for men who have abnormally low hormone levels due to disease or injury. Testosterone levels typically drop ... Read More

Lawsuit filed against Pfizer related to testosterone replacement drug

Pfizer’s testosterone replacement treatment Depo-Testosterone has become the subject of lawsuits questioning the safety and efficacy of the drugs after reports of heart attacks, strokes and blood clots in patients treated with the hormone. The lawsuit filed on behalf of Alvaro Roman Gutierrez alleges that Pfizer and its unit Pharmacia & Upjohn Co. LLC, conducted a “disease mongering” campaign to exaggerate the problem of low testosterone levels in men in order to boost sales of Depo-Testosterone. Gutierrez claims that Pfizer and Pharmacia & Upjohn spent millions of dollars to promote its drug to consumers and, along with other drug companies not ... Read More

New testosterone replacement capsule fares well in clinical trials

Clinical trials for Clarus Therapeutic’s new testosterone replacement treatment Rextoro show the drug is comparable to other testosterone therapies and, if approved by the Food and Drug Administration (FDA), could provide patients with yet another treatment option to boost the amount of the male hormone in their systems. Rextoro is a softgel capsule that contains a testosterone prodrug, testosterone undecanoate, or TU. It is formulated to foster absorption via the intestinal lymphatic pathway. After oral TU is absorbed, natural enzymes in the body cause testosterone to be released from the prodrug. “This proprietary formulation enables us to increase the amount ... Read More

Drug company tests new drug to boost testosterone levels in men

A new treatment designed to boost testosterone levels in men, which is not a testosterone replacement therapy, is currently being tested in clinical trials. If data is favorable, the drug could be considered for regulatory approval by the end of the year. Repros Therapeutics’ Androxal is a single isomer of clomiphene citrate, which is widely prescribed under the brand name Clomid to induce ovulation in women. The drug has been used off-label as a treatment of secondary male hypogonadism, a condition of low testosterone. Repros is developing Androxal for men of reproductive age with low testosterone due to secondary hypogonadism. ... Read More

Testosterone levels tend to fluctuate significantly in younger men but remain more constant in older men

Most schools of thought suggest that measuring testosterone levels in men can be tricky because the hormone levels vary from day to day as well as hour to hour. However, a new study finds that only young men experience statistically and clinically significant fluctuations in testosterone levels. Researchers studied records of more than 2,500 men ages 26 to 84 who had their testosterone levels checked at an erectile dysfunction clinic. The men were sorted into five age groups, beginning with 26- to 39-year-olds. Each of those groups were divided into sub-groups depending on the time of day their testosterone was ... Read More

Roberts says he would use testosterone therapy despite serious health risks

Morning Joe panelist Thomas Roberts says he would “live today, I will borrow from tomorrow” and take testosterone replacement therapy to boost his levels of the manly hormone if his levels were low, despite serious risks with the drugs including heart attacks, strokes and death. Roberts made the comment during Morning Joe’s segment on Time’s cover story “Manopause,” which addresses skyrocketing sales of testosterone supplements and health risks associated with the drugs. “We only got the now. I don’t know what’s going to happen tomorrow,” he said. Roberts is obviously being lured by television advertisements from drug companies that ask men ... Read More

Testosterone therapy does not appear to work in obese men with type 2 diabetes

Testosterone replacement therapy is designed to treat symptoms of “Low T,” such as low libido, weight gain, and fatigue; however, the treatment doesn’t appear to work on aging, obese men with type 2 diabetes, a new study shows. The new study published in The Journal of Clinical Endocrinology & Metabolism, found that testosterone supplements do not improve erectile dysfunction or general health in this population because testosterone levels are not the only issue causing their symptoms. The findings raise even more question about the controversial hormone supplements. Prescriptions for testosterone therapies, such as the widely used Androgel, Axiron and Testim, have skyrocketed ... Read More