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medication 93 articles

Makers of new diabetes drug hope more data will help drug win FDA approval

Blood sugar levels were improved, body weight was reduced, and blood pressure was lowered in patients who were given a new type 2 diabetes drug, according to the drug’s makers, Bristol-Myers Squibb and AstraZeneca. The treatment, known as dapagliflozin, was pitted against a placebo in clinical trials in patients with type 2 diabetes who were also taking a combination of metformin plus sulfonylurea. Dapagliflozin is a once daily pill that was approved in the European Union under the brand name Forxiga last November. It is also sold in Australia, Brazil, Mexico and New Zealand. Dapagliflozin works by removing excess blood ... Read More

Certain fruits can help protect against type 2 diabetes

Consuming certain fruits can help protect against type 2 diabetes, according to a large cohort study published in the British Medical Journal. The study focused on individual fruit consumption among more than 187,000 people who at the start of the study did not have diabetes, cardiovascular disease or cancer. The participants were given food frequency questionnaires every four years to analyze diet. The surveys specifically asked how often the people ate 10 different fruits including grapes or raisins; peaches, plums or apricots; prunes; bananas; cantaloupe; apples or pears; oranges; grapefruit; strawberries; and blueberries. They were also questioned about their intake ... Read More

Type 2 diabetes drug Bydureon recalled throughout Europe

About 92,000 vials of the type 2 diabetes drug Bydureon are being recalled throughout Europe because some of the vials of the long-acting medication were not fully filled. Bydureon is a weekly injectable version of the drug exenatide. It is the same medication in the type 2 diabetes drug Byetta. The affected drug, jointly marketed by AstraZeneca and Bristol-Myers Squibb Co., was recalled from the Netherlands, Ireland, Sweden, Finland and Spain. No Bydureon vials sold in the United States are affected. Spokesmen for the companies say that injecting under-filled vials should not pose any health concerns to patients. Bydureon has a ... Read More

ADHD drug Strattera could be dangerous for patients with serious heart problems

The attention deficit hyperactivity disorder (ADHD) medication Strattera (atomoxetine hydrochloride) has an updated safety label that warns that patients with severe cardiac or vascular disorders should not take the medication. The drug can cause increases in blood pressure or heart rate that could be deadly in patients with heart problems, especially those that worsen in the event of accelerated blood pressure or heart rate. The newly updated warnings and contraindications entry on Strattera’s safety label follow a previous warning from July 2012 in which researchers observed that in adult clinical trials some patients experienced elevated blood pressure and heart rates that could ... Read More

Some type 2 diabetes medications linked to increased risk of heart failure

New studies suggest two type 2 diabetes drugs do not increase the risk of heart attack, but may increase the risk of heart failure. A heart attack occurs when blood flow to part of the heart is blocked for a long enough time to cause damage or death to part of the heart muscle. Heart failure is a condition in which the heart cannot pump enough blood to the rest of the body. Both conditions can be deadly. Cardiovascular risks with diabetes medications have made headlines in recent years since the blockbuster diabetes drug Avandia was linked to fatal heart ... Read More

Psychiatric side effects of anti-malaria drug may be used to sway jury in soldier sentencing

The attorney for a U.S. soldier who killed 16 Afghan civilians in 2012 says his client took an anti-malaria medication used for years by the U.S. military before carrying out the mass murder. The drug has been linked to psychiatric problems that could serve as a defense for U.S. Army Staff Sgt. Robert Bales during a sentencing hearing next month, during which jurors will decide whether Bales should receive a life sentence without the possibility of parole or be eligible for consideration to be released from prison. Mefloquine is a drug used to prevent malaria or treat mild to moderate ... Read More

Januvia sales may be threatened by pancreatitis, pancreatic cancer risk

Drug maker Merck is putting most of its earnings “eggs” in one basket – Januvia, a type 2 diabetes drug – after its top-selling Singular went off patent protection and generic competition moved in. However analysts are unsure Januvia can fill the $1 billion Singular has left behind. Januvia is in a class of type 2 diabetes medications known as DPP-4 drugs. It works by inhibiting the action of the DDP-4 enzyme. It is designed to reduce blood sugar levels in patients with type 2 diabetes. The drug goes head-to-head with Onglyza, which got off to a slow start but ... Read More

Prescription drug deaths rise for 11th consecutive year

The number of prescription drug-induced deaths rose for the 11th straight year, according to a Centers for Disease Control and Prevention (CDC) analysis. Most of the drug deaths were accidents involving potent painkillers such as OxyContin and Vicodin. “This is a big problem that has gotten much worse quickly,” said CDC Director Dr. Thomas Frieden. Prescription drug deaths continue to rise despite efforts to raise awareness of the risks among doctors and patients. The CDC reported a total of 38,329 drug-overdose fatalities nationwide in 2010. Nearly 60 percent of those deaths involved medicines, most of them prescription drugs. In 2009, the ... Read More

Johnson and Johnson ordered to pay $63 million to girl who suffered severe reaction to Children’s Motrin

Consumer health product giant Johnson & Johnson has been ordered to pay $63 million plus interest to a Massachusetts teenager who suffered a serious skin reaction and lingering medical complications after taking the pain reliever Children’s Motrin. Samantha Reckis was given the ibuprofen when she was 7, an over-the-counter medicine she had taken previously without experiencing ill effects. But this time, Samantha suffered a severe reaction. Her throat, mouth, eyes, esophagus, intestinal tract, respiratory system and reproductive system became inflamed, and her doctors had to put Samantha into a coma to treat her. She was diagnosed with toxic epidermal necrolysis ... Read More

Eli Lilly, Boehringer Ingehleim testing experimental diabetes drug

Initial results from several late-stage studies show a new type 2 diabetes treatment known as empagliflozin is more effective than a placebo in reducing blood sugar levels. Empagliflozin is a once-daily tablet developed by Eli Lilly and Co. and German drug maker Boehringer Ingelheim. The drug is being tested in both 10- and 25-milligram doses. Side effects include genital infections. The drug companies say they plan to seek approval for empagliflozin later this year in the United States, Europe and Japan. The two drug companies have teamed up to design and sell several diabetes treatments, however Boehringer Ingelheim recently ended ... Read More