Tagged Articles

multiple myeloma 7 articles

FDA places clinical hold on Keytruda trials

The Food and Drug Administration (FDA) has placed a clinical hold on three trials involving the cancer drug Keytruda (pembrolizumab) in patients with the blood cancer multiple myeloma, raising concerns about the number of patients who have died after receiving the drug. The announcement comes just weeks after a review by the Data Monitoring Committee during which more deaths were observed in patients who had been treated with Keytruda, which led to the FDA ordering a hold on new enrollment in two of the three studies. Merck was testing the anti-PD-1 therapy in one trial with Keytruda in combination with Pomalyst ... Read More

Turtle Wax named in benzene exposure lawsuits

In two unrelated lawsuits, Turtle Wax, Inc. is being sued over diseases allegedly caused by exposure to benzene contained in its products. Matthew Eaton, an employee of Turtle Wax, filed a lawsuit claiming he developed acute Acute Myeloid Leukemia (AML) after long-term exposure to benzene in the wax, reports Madison-St. Clair Record. The lawsuit was filed on May 12 in the Madison County Circuit Court, claiming the company was responsible for his development of a life-threatening, benzene-related disease. According to Eaton, he will now endure a lifetime of physical pain and mental suffering due to the disease and its required treatment. ... Read More

Louisiana Man Says Products Containing Benzene Caused Injuries

A New Orleans couple are suing multiple companies over injuries they allege are caused by exposure to benzene containing products. Miles and Angeline Elder have filed a lawsuit against the makers of Liquid Wrench and Gunk, saying the benzene in the product caused Miles’ tissue damage that led to multiple myeloma. Elder claims to have had prolonged exposure as well as extended uses of the product and other benzene-containing household chemicals. The companies include CRC Industries, Berryman Products, W.M. Barr & Co., Radiator Specialty Co., U.S. Steel, Shell Oil, Harry’s Hardware, and Mike’s Hardware and Supply. The companies are being accused of negligence ... Read More

Sagent Pharmaceuticals recalls Zoledronic Acid bone treatment

Sagent Pharmaceuticals is recalling two lots of Zoledronic Acid Injection, a drug used to treat high blood calcium levels, because four leaking premix bags were detected during an investigation spurred by a product complaint. The leaking bags pose a sterility risk. The company says that the affected bags were not administered to patients because the leakage was readily apparent. Zoledronic Acid Injection is used to treat high calcium levels, called hypercalcemia, which is a condition that sometimes occurs in cancer patients. The solution also treats bone damage caused by Paget’s disease, multiple myeloma, and cancers that have spread to the ... Read More

FDA approves generic cancer drug to cover drug shortages caused by quality control issues at manufacturing plant

The first generic version of the cancer drug Doxil has been approved by the Food and Drug Administration (FDA), which may help a drug shortage that has led to rationing and less-effective care for cancer patients. Doxil was approved in 1995 to treat ovarian cancer, AIDS-related Kaposi’s sarcoma and multiple myeloma. The drug is made by Johnson & Johnson under contract by manufacturer Ben Venue Laboratories, a unit of German drug maker Boehringer Ingelheim. Supplies from Ben Venue began running short due to quality control problems. In November 2011, operations at Ben Venue were suspended after an FDA investigation found ... Read More

Bristol-Myers Squibb recalls chemotherapy drug

More than 31,000 units of a chemotherapy drug are being recalled by manufacturer Bristol-Myers Squibb Co., because one vial was found to be overfilled, which puts patients at risk for overdose. The recall affects 10 lots of BiCNU, an injection of the drug carmustine, which is used to treat brain tumors, multiple myeloma, Hodgkin’s disease and non-Hodgkin’s lymphoma. An overdose of BiCNU could result in lung or kidney toxicity. No adverse events have yet been reported. BiCNU was manufactured by Ben Venue Laboratories, a manufacturing contractor that Bristol-Myers Squibb no longer uses. The recall affects products sold in the United ... Read More

1986 study questions link between propoxyphene and type of cancer

Thirty-five years before the Food and Drug Administration (FDA) decided to pull the painkiller propoxyphene from the market because of serious health risks, researchers were already questioning the harm the drug could do. Known by the brand names Darvon and Darvocet, propoxyphene-containing drugs were already targeted years ago for unusually high incidences of dangerous and often fatal overdoses. It was data from a new study that showed the drugs also put users at risk for potentially fatal heart rhythm abnormalities that led the FDA to ban the drug in the United States, a move that was preceded by numerous European ... Read More