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paroxetine 24 articles

Lawsuit blames antidepressant Paxil for man’s suicide

U.S. District Judge James B. Zagel declined motions for a summary judgment by the defendant and ruled that a lawsuit blaming drugmaker GlaxoSmithKline (GSK) of manipulating data linking its antidepressant Paxil to suicide should move straight to trial. The lawsuit was filed by Wendy Dolin, widow of Reed Smith LLP attorney Stewart Dolin, who committed suicide shortly after beginning treatment with Mylan Inc.’s generic version of Paxil, known chemically as paroxetine. Mylan is also named in the lawsuit. Dolin claims that GSK attempted to downplay the risks of Paxil in one clinical trial by increasing the number of suicide attempts ... Read More

Paxil during pregnancy linked to birth defects

Women who use the antidepressant Paxil during the first trimester of pregnancy are at greater risk of delivering a baby with birth defects, including life threatening heart defects, according to a recent analysis published in the British Journal of Clinical Pharmacology. Paxil, known generically as paroxetine, is in a class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs. Other drugs in this class include Zoloft, Celexa, Lexapro and Prozac. Medications in this class are the most common treatment for mild to moderate depression. Paxil was considered safe for use in pregnant women until 2005, when a small study ... Read More

SSRIs linked to increased risk of bleeding events, transfusions after surgery

People who use antidepressants known as selective serotonin reuptake inhibitors (SSRI) and undergo surgery are more likely to have bleeding events, need transfusions, suffer from irregular heart functions, stay in the hospital longer, and die shortly after surgery than people not on antidepressants who had surgery, according to a new study. SSRIs are the most commonly prescribed antidepressants on the market today and include brand names such as Prozac (fluoxetine), Zoloft (sertraline), and Paxil (paroxetine). Numerous studies have shown the dangers of SSRIs on developing fetuses when taken by pregnant women, and on suicide risks when taken by adolescents. The ... Read More

SSRIs during pregnancy linked to newborn seizures

Babies born to mothers who used antidepressants during their pregnancy are more likely to be born premature or suffer a seizure shortly after birth, according to a new study published in the American Journal of Obstetrics & Gynecology. The new study backs up concerns raised by previous studies that antidepressant use among pregnant women is dangerous to developing fetuses despite what drug companies claim on their safety labels. The new study found that among nearly 229,000 babies born in Tennessee, those born to women who used antidepressants during their second trimester were more likely to be born an average of ... Read More

New warning of serious skin rash issued for antidepressant Paxil

A new side effect has been added to the safety label of the antidepressant Paxil (paroxetine) following reports that some patients who used the drug developed a rare but life-threatening rash known as Stevens Johnson Syndrome (SJS). Paxil is in a class of medications known as selective serotonin reuptake inhibitors, or SSRIs. Other drugs in this class include Zoloft, Celexa, Lexapro and Prozac. SSRIs are among the most prescribed medications in the United States and are used to treat depression and anxiety. SJS is an allergic reaction to medication. It is most often liked to anti-inflammatory drugs and antibiotics. The ... Read More

SSRIs linked to weight gain, birth defects

Several drugs to treat mood disorders, including commonly prescribed antidepressants, have been linked to weight gain, according to a new study. Ryan Roux, chief pharmacy officer with the Harris County Hospital District in Houston, and his team of researchers compiled a list of medications that promote weight gain, are weight neutral or are associated with weight loss. A popular class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs, are among the drugs that can cause patients to pack on pounds, the study claims. SSRIs are one of the most prescribed drugs in the country. The “weight promoting” brands ... Read More

Pregnant women who use SSRIs are less likely to breast feed

Women who take a type of antidepressant known as selective serotonin reuptake inhibitor (SSRI) during pregnancy are far less likely to breast-feed their babies than women who did not take the medication while pregnant, according to a new study. Researchers with Connecticut Pregnancy Exposure Information Service, a state-funded service that provides women with information about exposures during pregnancy and breast-feeding, pored through data from 466 pregnant women who contacted the CPEIS’ California affiliate over 10 years with questions about a variety of exposures. The results showed that women who took an SSRI at any time during their pregnancy were about ... Read More

SSRIs can cause weight gain, birth defects

Antidepressants may cause weight gain and are often prescribed to simulate appetite, according to a report by CBS 8 Health Day. Antidepressants that promote weight gain include Paxil (paroxetine) and Zoloft (sertraline). Wellbutrin (bupropion) and Prozac (fluoxetine) are considered weight-neutral or weight-loss drugs. All the drugs listed above are in a class of medications known as selective serotonin reuptake inhibitors, or SSRIs. These newer types of antidepressants are among the most prescribed medications in the United States. Typically, older antidepressants tend to cause more weight gain than the newer SSRIs, but the risk of weight gain is noted. Often it ... Read More

Another study shows PPHN risk with SSRI exposure

A new study, published in the January 12 issue of the British Medical Journal, adds more evidence that antidepressants known as selective serotonin reuptake inhibitors, or SSRIs, when used during pregnancy, can increase the chances that the newborn will have a life-threatening lung defect known as persistent pulmonary hypertension (PPHN). The study, conducted by researchers at Karolinska Institute in Stockholm, Sweden, found that infants born to women who took SSRIs late in their pregnancy had a two-fold increase of having PPHN compared to infants born to women who did not take the drugs. The absolute risk was three infants per ... Read More

SSRIs still considered risky during pregnancy

Scientists are currently debating whether there is a link between a class of antidepressants known as selective serotonin reuptake inhibitors (SSRI) and the risk of suicidal ideation and behavior, a problem identified shortly after the highly prescribed drugs hit the market. Newer studies suggest that there is no increased risk of suicide, and others show that the risk of suicide attempts in adults who start taking SSRIs is actually reduced, particularly in men and especially with sertraline, known by the brand name Zoloft. These findings are published in a recent issue of the journal Lancet. This is good news to ... Read More