Study links Paxil use in first trimester of pregnancy to serious birth defects
Results of a scientific study indicate birth defects in infants born to women taking antidepressants, including Paxil, during the first trimester of pregnancy. In fact the study revealed a greater risk for women who took Paxil (paroxetine) in the first trimester, as opposed to other antidepressents.
As a result of the study, in September 2005 drug manufacturer GlaxoSmithKline informed health care professionals that it was updating the Pregnancy subsection of the PRECAUTIONS section of the labels for the drug Paxil (paroxetine HCI) and Paxil CR controlled-release tablets to indicate the Paxil side effects.
The study revealed a greater risk for overall birth defects for women using proxetine, and an increased risk for heart defects specifically. Read more about Paxil and birth defects.
Recent studies have shown that some types of antidepressants increase the risk for birth defects when mothers take them while pregnant. But new studies suggest that the medication may also cause problems with the pregnancy itself. The new study, published in the British Journal of Clinical Pharmacology found that pregnant women who use antidepressants known as selective serotonin reuptake inhibitors (SSRIs) have a slightly higher risk of developing dangerously high blood pressure, a condition known as preeclampsia that can be harmful for both mother and the unborn child. SSRIs are among the most prescribed medications in the United States, and ... Read More
A new iPad app can help doctors determine the best antidepressant to treat patients. The new Clinaptica Depression Consultant app was developed by Scaled Psychiatric Systems, Inc. It costs $4.95 at the App Store, and is designed to go beyond any previous system for people with depressive disorders to recommend antidepressant therapies specific to different patient characteristics. Arizona Physician Dr. Rakesh Patel has used an online version of the program since 2006 and says the treatment recommendations have been “spot on almost every time.” A multi-study presented at the American Psychiatric Association’s annual meeting in 2009 showed that a sample ... Read More
A U.S. judge has ruled that GlaxoSmithKline Plc (GSK) can sell a generic copy of its Paxil CR antidepressant to Apotex Inc., denying a bid from generic drug company Mylan to block the sale. Mylan signed a two-year agreement in 2008 to market a copy of Paxil. It claimed GSK was breaching its contract by selling a copy of Paxil to another drug company. Since Paxil was approved by the Food and Drug Administration (FDA) in 1992, it has become one of the most widely prescribed antidepressants in the world. Paxil is in a class of medications known as selective ... Read More
Women who take a type of antidepressant known as selective serotonin reuptake inhibitor (SSRI) during pregnancy are far less likely to breast-feed their babies than women who did not take the medication while pregnant, according to a new study. Researchers with Connecticut Pregnancy Exposure Information Service, a state-funded service that provides women with information about exposures during pregnancy and breast-feeding, pored through data from 466 pregnant women who contacted the CPEIS’ California affiliate over 10 years with questions about a variety of exposures. The results showed that women who took an SSRI at any time during their pregnancy were about ... Read More
Most doctors advise their patients with depression not to take antidepressants during pregnancy because the drugs may cause serious birth defects. However, a new study shows that not treating depression during pregnancy may cause poor birth outcomes as well. The study, published in the Archives of General Psychiatry, involved about 8,000 pregnant women in the Netherlands who were asked once each trimester about their depression symptoms and whether they used antidepressants. The antidepressants studied in the research involved a class of medication known as selective serotonin reuptake inhibitors (SSRI), which includes brand names such as Paxil, Zoloft, Prozac, Celexa and ... Read More
Antidepressants may cause weight gain and are often prescribed to simulate appetite, according to a report by CBS 8 Health Day. Antidepressants that promote weight gain include Paxil (paroxetine) and Zoloft (sertraline). Wellbutrin (bupropion) and Prozac (fluoxetine) are considered weight-neutral or weight-loss drugs. All the drugs listed above are in a class of medications known as selective serotonin reuptake inhibitors, or SSRIs. These newer types of antidepressants are among the most prescribed medications in the United States. Typically, older antidepressants tend to cause more weight gain than the newer SSRIs, but the risk of weight gain is noted. Often it ... Read More
Currently, doctors and psychiatrists are weighing the legitimacy of a condition known as Premenstrual Dysphoric Disorder (PMDD) to determine if it deserves a listing in the Diagnostic and Statistical Manual of Mental Disorders (DSM), the American Psychiatric Association’s bible for mental health professionals. A new edition of the DSM has not been issued since 1987, and in it PMDD is not considered an actual disorder but rather a condition in need of “further study.” Granting PMDD its own diagnosis in the DSM will almost certainly guarantee one thing – that drug companies will be clamoring to create a drug to ... Read More
In January, the British Medical Journal reaffirmed a U.S. Food and Drug Administration (FDA) warning when it published a study that showed a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs), were linked to serious birth defects in newborns when taken by the mothers while they were pregnant. SSRIs include the brand names Paxil, Zoloft, Celexa, Lexapro and Prozac, and the birth defects associated with these pills include heart defects, lung conditions, brain and spine defects, skull deformities, club foot, and abdominal defects. That study followed warnings from several institutions and medical publications such as the New England ... Read More
Three new lawsuits have been filed against the makers of the antidepressant Lexapro by women who claim that using the drug during pregnancy caused them to deliver babies with various birth defects including spina bifida and club foot. Lexapro is in a class of medications known as selective serotonin reuptake inhibitors, or SSRIs. Other drugs in this class include the brand names Paxil, Zoloft, and Prozac. SSRIs are among the most prescribed medications in the country and have been considered relatively safe to use during pregnancy because there were no tests that suggested the drugs could cause problems in developing ... Read More
More lawsuits have been filed against drug maker Pfizer by women who claim that the company hid information that showed using the antidepressant Zoloft during pregnancy could cause birth defects. The class action lawsuit was filed in St. Louis Circuit Court against Pfizer. The women claim they were prescribed Zoloft during their pregnancies despite the alleged risks to their unborn children. The woman say their children were later born with several birth defects, including damage to their hearts. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors, or SSRIs. Other brand name medications in this class ... Read More