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persistent pulmonary hypertension 38 articles

New study suggests SSRI use during pregnancy increases risk of autism spectrum disorders in children

Women using antidepressants known as SSRIs (selective serotonin reuptake inhibitors) during pregnancy may be at higher risk of having children with autism spectrum disorders, according to a new study published in the Journal of Autism and Developmental Disorders. Several studies have raised red flags with the use of SSRIs during pregnancy. SSRIs, which include the brand names Zoloft, Paxil, Lexapro, Celexa and Prozac, have been linked to birth defects such as persistent pulmonary hypertension, heart defects, neural tube defects and malformations. Studies have also suggested that children exposed to SSRIs in utero are more likely to have behavioral problems and ... Read More

Study: Children exposed to SSRIs in utero at greater risk for obesity, type 2 diabetes

Babies born to women who took antidepressants while pregnant are more likely to become obese and develop type 2 diabetes, according to a new study. Obesity and type 2 diabetes in children is already on the rise in the United States and is generally blamed on poor diets and reduced physical activity. However, researchers with McMaster University say that maternal antidepressant use may also be a contributing factor in the pediatric obesity and diabetes epidemic. The study focused on a commonly prescribed type of antidepressant known as selective serotonin reuptake inhibitors, or SSRIs, which include the brand names Prozac, Lexapro, ... Read More

SSRI use in third trimester linked to persistent pulmonary hypertension (PPHN) in newborns

Babies born to women who used SSRI antidepressants during the third trimester of their pregnancies were at an increased risk of giving birth to a baby with persistent pulmonary hypertension in the newborn, or PPHN, according to new research. The study, conducted by researchers with the Sunnybrook Health Sciences Center in Toronto, Canada and the University of Toronto, involved data from seven meta-analyses. Researchers looked at maternal use of SSRIs, or selective serotonin reuptake inhibitors, during different trimesters of pregnancy and the incidence of PPHN. The greatest risk of PPHN was found to be in the third trimester. SSRIs include ... Read More

Boys with autism more likely to have been exposed to SSRIs in womb

Boys born to women who took a type of antidepressant during pregnancy were three times more likely to be diagnosed with autism than boys who were not exposed to the drugs in utero, a new study has found. The greatest risk was in boys who were exposed to the drugs during the mother’s first trimester of pregnancy. Researchers also found boys exposed to these antidepressants were more likely to have developmental delays. The new study, published this week online and in the May issue of the journal Pediatrics, focused on a commonly prescribed class of antidepressants known as selective serotonin ... Read More

Large study establishes link between SSRI use during pregnancy and birth defects

In December 2011, the Food and Drug Administration (FDA) recommended that health care providers not alter their current practice for treating depression in pregnant patients. The recommendation was based on a review of data that up to that point had been inconsistent on whether using antidepressants known as selective serotonin reuptake inhibitors (SSRIs) could cause harm to developing fetuses if taken by the mother during pregnancy. However, a month after the FDA’s announcement that studies had not established a link between use during pregnancy and birth defects, a large retrospective cohort study was published that strongly suggests that SSRI exposure ... Read More

Few resources give reliable information about safety of medication during pregnancy

Women have few reliable and easy-to-understand resources available to tell them what medications may be harmful to their unborn child if the drugs are used during pregnancy, the Centers for Disease Control and Prevention (CDC) has found. Women usually search the internet for information about pregnancy in general. However, when CDC researchers examined 25 pregnancy-related websites they found contradictory information about which drugs pose risks to pregnant women or their fetuses. One site listed 22 products as safe that were considered risky on another site. Plus, there was no information to back up safety claims made for 40 percent of ... Read More

Large study finds anti-nausea drug is safe for pregnant women

Reassurance that drugs are safe to use during pregnancy is hard to come by, especially since it is too risky to run clinical trials on pregnant women to determine whether a drug can cause birth defects. And what if a drug is designed to actually treat a bothersome symptom of pregnancy, such as morning sickness? How can a woman be sure the drug is safe for her developing fetus? Now, researchers say they can give women some peace of mind about using an anti-nausea drug while they are pregnant. A large study on Danish women shows that GlaxoSmithKline’s drug Zofran, ... Read More

New drug reaction warnings placed on SSRI and SNRI antidepressants

Patients who use some types of antidepressants with other serotonergic drugs are at an increased risk for developing a potentially life threatening drug reaction known as serotonin syndrome. The drug labels for several antidepressants in the selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) classes now contain a new warning that the drugs should not be used with other serotonergic drugs (including Triptans, Tricyclic antidepressants, Fentanyl, Lithium, Tramadol, Tryptonphan, Buspirone, and St. John’s Wort) and with drugs that impair metabolism of serotonin (in particular, MAOIs, both those intended to treat psychiatric disorders and also others, such as Linezolid and ... Read More

First SSRI Prozac celebrates 25th birthday this month

This month marks the 25th anniversary of the antidepressant Prozac (fluoxetine). The drug, the first in a class known as selective serotonin reuptake inhibitors (SSRIs) was launched in January 1988. Since then the drug has enjoyed increasing sales. Prozac was prescribed 3.9 million times in 2011 – a 9.2 percent increase from 2010 sales. Prozac, which is now also available in generic versions, is approved by the Food and Drug Administration (FDA) for the treatment of adult and pediatric major depression, adult and pediatric obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). It is also used to ... Read More

50th anniversary for Kefauver-Harris Amendment to ensure safer, more effective drugs

This year marks the 50th anniversary of the Kefauver-Harris Amendment, action that required drug companies provide more thorough data on the safety and efficacy of prescription drugs before they are approved. The amendment led to the development of evidence-based drug evaluations carried out by the Food and Drug Administration (FDA). Despite these efforts, some drug companies still try to withhold information on adverse drug reactions in order to bolster their own profits. Much of the credit for the passage of the Kefauver-Harris Amendment goes to Frances O’Kelsey. More than 50 years ago, when O’Kelsey was first hired to serve as ... Read More