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PPHN 24 articles

Older antidepressants Prozac, Paxil linked to birth defects

The antidepressants Prozac and Paxil are more likely to cause birth defects in babies born to women who use the drugs while pregnant than newer antidepressants in the same class, according to a study published recently in the British Medical Journal. Prozac and Paxil are in a class of antidepressant drugs known as selective serotonin reuptake inhibitors, or SSRIs. Makers of these medications face thousands of lawsuits from women who claim they were not warned that using the drugs while pregnant could cause birth defects, including a lung defect known as persistent pulmonary hypertension of the newborn (PPHN), heart defects, ... Read More

Study links antidepressant use during pregnancy to serious birth defect

Pregnant women who take antidepressants had a small but statistically significant increased risk of their babies being born with a life threatening lung defect called persistent pulmonary hypertension of the newborn, or PPHN, according to a new population-based study. PPHN is a condition in which a newborn baby’s circulation changes back to the circulation of a fetus, where much of the blood flow bypasses the lungs. When blood is shunted away from the baby’s lungs, it is difficult for the lungs to exchange oxygen and carbon dioxide, resulting in low blood oxygen levels. This can be serious and cause organ ... Read More

Antidepressant use during pregnancy remains controversial issue

A new study suggesting that there is no increased risk of heart defects in newborns exposed to antidepressants in the first three months of gestation is being criticized by medical experts. “While this is an excellent group of researchers, there are some serious flaws with this study,” says Dr. Adam Urato, maternal-fetal medicine specialist at Tufts Medical Center in Boston. “This isn’t rocket science. We know that exposing developing babies to synthetic chemicals is almost always a really bad idea and should be avoided whenever possible. This study does nothing to alter that common sense concolusion.” The study, conducted by ... Read More

SSRI use in third trimester linked to persistent pulmonary hypertension (PPHN) in newborns

Babies born to women who used SSRI antidepressants during the third trimester of their pregnancies were at an increased risk of giving birth to a baby with persistent pulmonary hypertension in the newborn, or PPHN, according to new research. The study, conducted by researchers with the Sunnybrook Health Sciences Center in Toronto, Canada and the University of Toronto, involved data from seven meta-analyses. Researchers looked at maternal use of SSRIs, or selective serotonin reuptake inhibitors, during different trimesters of pregnancy and the incidence of PPHN. The greatest risk of PPHN was found to be in the third trimester. SSRIs include ... Read More

Large study establishes link between SSRI use during pregnancy and birth defects

In December 2011, the Food and Drug Administration (FDA) recommended that health care providers not alter their current practice for treating depression in pregnant patients. The recommendation was based on a review of data that up to that point had been inconsistent on whether using antidepressants known as selective serotonin reuptake inhibitors (SSRIs) could cause harm to developing fetuses if taken by the mother during pregnancy. However, a month after the FDA’s announcement that studies had not established a link between use during pregnancy and birth defects, a large retrospective cohort study was published that strongly suggests that SSRI exposure ... Read More

First SSRI Prozac celebrates 25th birthday this month

This month marks the 25th anniversary of the antidepressant Prozac (fluoxetine). The drug, the first in a class known as selective serotonin reuptake inhibitors (SSRIs) was launched in January 1988. Since then the drug has enjoyed increasing sales. Prozac was prescribed 3.9 million times in 2011 – a 9.2 percent increase from 2010 sales. Prozac, which is now also available in generic versions, is approved by the Food and Drug Administration (FDA) for the treatment of adult and pediatric major depression, adult and pediatric obsessive-compulsive disorder, bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). It is also used to ... Read More

Doctor warns of possible serious complications from antidepressant use during pregnancy

What if there were a virus affecting 5 percent of all pregnant women that caused significant pregnancy complications? More than 10 percent of those infected miscarry, as many as 20 percent deliver their babies preterm, and 30 percent of babies are born with birth defects, have difficulty breathing, or experience a seizure shortly after birth. “If this were to occur it would be considered a public health emergency and a tremendous effort would be put forth to address it,” writes Dr. Adam Urato, a maternal-fetal medicine physician at Tufts Medical Center and guest commentator on Common Health. “Yet, this epidemic ... Read More

New warning of serious skin rash issued for antidepressant Paxil

A new side effect has been added to the safety label of the antidepressant Paxil (paroxetine) following reports that some patients who used the drug developed a rare but life-threatening rash known as Stevens Johnson Syndrome (SJS). Paxil is in a class of medications known as selective serotonin reuptake inhibitors, or SSRIs. Other drugs in this class include Zoloft, Celexa, Lexapro and Prozac. SSRIs are among the most prescribed medications in the United States and are used to treat depression and anxiety. SJS is an allergic reaction to medication. It is most often liked to anti-inflammatory drugs and antibiotics. The ... Read More

Judge OKs sale of generic Paxil despite risk for birth defects

A U.S. judge has ruled that GlaxoSmithKline Plc (GSK) can sell a generic copy of its Paxil CR antidepressant to Apotex Inc., denying a bid from generic drug company Mylan to block the sale. Mylan signed a two-year agreement in 2008 to market a copy of Paxil. It claimed GSK was breaching its contract by selling a copy of Paxil to another drug company. Since Paxil was approved by the Food and Drug Administration (FDA) in 1992, it has become one of the most widely prescribed antidepressants in the world. Paxil is in a class of medications known as selective ... Read More

BMJ confirms FDA’s warning that SSRIs can cause birth defects

In January, the British Medical Journal reaffirmed a U.S. Food and Drug Administration (FDA) warning when it published a study that showed a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs), were linked to serious birth defects in newborns when taken by the mothers while they were pregnant. SSRIs include the brand names Paxil, Zoloft, Celexa, Lexapro and Prozac, and the birth defects associated with these pills include heart defects, lung conditions, brain and spine defects, skull deformities, club foot, and abdominal defects. That study followed warnings from several institutions and medical publications such as the New England ... Read More