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PPIs 56 articles

Kidney disease: how what you’re consuming affects kidney health

Chronic kidney disease (CKD) is a worldwide epidemic. Twenty-six million American adults have CKD and millions of others are at increased risk. Kidney disease is the ninth leading cause of death in the U.S. The life-threatening disease is known to be associated with high blood pressure and diabetes. Because of its link to diabetes, researchers in the Netherlands decided to study the impact of diet on kidney function, as a diet rich in whole grains, fruits and vegetables has been associated with lower risk of diabetes. For five years, the researchers checked kidney function by monitoring the estimated glomerular filtration ... Read More

Study warns against PPI use for people with cystic fibrosis

Researchers at the University of Florida have linked acid reducing proton pump inhibitors, or PPIs, such as Prevacid, Nexium and Prilosec, to another risk. They are already under fire for links to kidney disease and kidney failure. The manufacturers of these drugs are being sued by many patients with serious kidney injuries who allege “negligence, design defect, failure to warn, fraudulent concealment, warranty claims and loss of consortium” as the cause of action against defendants. The popular drugs have also been linked to increased risk for gastric cancer, stroke, heart attack, dementia, C. difficile infections, and bone fractures. The new ... Read More

Acknowledgement of PPI risks is decades late, researchers say

In a letter published in Gut, Norwegian researchers comment on two recent studies linking the use of acid-reducing proton pump inhibitors, or PPIs, to gastric cancer. Hong Kong researchers published findings in early November that long-term PPIs use, even after Helicobacter pylori eradication therapy, is still associated with an increased risk of gastric cancer. At the same time a Swedish study reported incidence of gastric cancer to be linked to long-term PPI use. In their letter titled, “Proton pump inhibitors and gastric cancer: a long expected side effect finally reported also in man,” Professor Helge Lyder Waldum, Department of Clinical ... Read More

Tips for managing heartburn symptoms this Thanksgiving

The week of Thanksgiving is the 18th Annual GERD Awareness Week. Gastroesophageal reflux disease, or GERD, is very common, affecting millions of Americans. Its most common symptom is heartburn, specifically heartburn that occurs multiple times a week, is severe enough to wake a person from sleep, or occasional heartburn that is associated with difficulty swallowing or has persisted for five or more years. Another common symptom is acid regurgitation. Other less common symptoms include belching, difficulty or pain when swallowing, sudden excess of saliva, dysphagia (the sensation of food sticking in the esophagus), chronic sore throat, laryngitis, inflammation of the gums, ... Read More

Thanksgiving week is also GERD Awareness Week

Gastroesophageal reflux disease, or GERD, is most commonly associated with symptoms of heartburn and acid reflux and it affects millions of Americans. It occurs when the barrier between the stomach and esophagus is compromised and the stomach’s contents flow back into the esophagus. It can cause tissue damage to the lining of the esophagus and can increase risk of a pre-cancerous disease called Barrett’s esophagus. Perhaps appropriately, the week when most Americans are likely to overeat as they celebrate Thanksgiving with a feast of turkey, dressing, cranberry sauce, numerous casseroles and slices of pie, Nov. 19-25, 2017 is GERD Awareness ... Read More

New study confirms heartburn drugs linked to progression of kidney disease

Proton pump inhibitors, or PPIs, used to treat heartburn, acid reflux and ulcers, are some of the most prescribed drugs in the world. PPIs are sold under name brands such as Prevacid, Nexium and Prilosec, by prescription and over the counter, and they are taken by more than 20 million Americans in any given year. “PPIs have been regarded as generally safe and without serious adverse effects. However, this perspective is changing,” said Danish scientists earlier this year when they published a study linking the drugs to an increased risk for serious foodborne infection, listeriosis. The drugs have been linked ... Read More

Study links PPIs to risk of stroke and heart attack

A study published on Oct. 12, 2017, in Journal of Internal Medicine is linking common acid-reducing drugs to increased risk of strokes and heart attacks. Proton pump inhibitors, or PPIs, such as Prevacid, Nexium and Prilosec, are available both by prescription and over-the-counter and are taken by millions of Americans to treat ulcers, heartburn and acid reflux. When the researchers presented their preliminary findings last year at an American Heart Association conference, Dr. Thomas Sehested, the study’s lead author and a researcher at the Danish Heart Foundation, commented according to KFOR that, “PPIs have been associated with unhealthy vascular function, ... Read More

Equine study explores natural alternatives to PPI side effects

Popular acid-reducing drugs known as proton pump inhibitors (PPIs), which include brand names Prevacid, Nexium and Prilosec, are taken by millions of Americans. These drugs have been under fire for being over prescribed and for patients remaining on them much longer than medically necessary. They have also been linked to numerous side effects such as increased risk of chronic kidney disease and kidney failure, stomach infections, heart disease, pneumonia, bone fractures, and dementia, to name just a few. Many doctors and patients are looking for alternate treatments for ulcers, heartburn and acid-reflux symptoms. Interestingly, this isn’t only an issue for ... Read More

Call to deprescribe PPIs intensifies after drugs linked to persistent dermatological reaction

Proton pump inhibitors, or PPIs, used to treat symptoms of heartburn and acid reflux have been linked to side effects such as kidney disease, stomach infections, heart disease, pneumonia, bone fractures, and dementia, and even higher risk of death when compared to other drugs used to treat similar issues. Available both over-the-counter and by prescription, these popular drugs are taken by millions of Americans. PPIs have a reputation for being over-prescribed and used long-term when it is not medically necessary. Health care reformers have long been making efforts to limit PPI overuse and as more and more researchers raise awareness about ... Read More

PPIs linked to progression of chronic liver disease

For years, studies have been linking proton pump inhibitors (PPIs), such as Prilosec, Nexium and Prevacid, to kidney damage such as Acute Interstitial Nephritis (AIN), increased risk of Acute Kidney Injury (AKI or Acute Renal Failure) and Chronic Kidney Disease, as well as many other concerning side effects. These acid reflux and heartburn drugs, available both by prescription and over-the-counter, are consumed by approximately 10 percent of the population and Americans are estimated to spend $11 billion on PPIs yearly. A new study published by researchers at University of California San Diego School of Medicine in Nature Communications is now ... Read More