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preterm birth 17 articles

New study shows increased risk of autism in children exposed to SSRIs in utero

Children exposed to antidepressants in their mother’s womb are more likely to develop autism than children who were not exposed to the drugs, a new study suggests. The study identified the risk with both selective serotonin reuptake inhibitors (SSRIs) and nonselective monoamine reuptake inhibitors, or tricyclic antidepressants. This is the second study in two years to associate antidepressant use during pregnancy with an increased risk of autism in offspring. SSRIs are among the most commonly prescribed drugs in the United States, and include brand names such as Zoloft, Paxil, Celexa, Lexapro and Prozac. All SSRIs but Paxil are listed as ... Read More

SSRI use during fertility treatments shows little benefit to mother or fetus

Depressed women taking selective serotonin reuptake inhibitors (SSRIs) who are also undergoing infertility treatment may be more likely not to conceive, to suffer complications with pregnancy, and to have a baby with birth defects, a new meta-analysis shows. Women undergoing infertility treatments often battle depression. A study published in Medical News Today investigated depressed women undergoing infertility treatment and the risks to their fetuses while taking SSRIs. The new meta-analysis took a different approach than past studies, investigating the safety and efficacy of infertile women being treated with SSRIs. Researchers culled through studies and found that SSRI is associated with lowered ... Read More

SSRIs may not increase stillbirth, infant death, but still carry birth defect risk

The most widely prescribed class of antidepressants, if taken during pregnancy, do not increase the risk of stillbirth or newborn death, a new study suggests. However, several studies have shown that the drugs can cause birth defects, premature birth, and other problems. The lastest study was published in the Journal of the American Medical Association (JAMA) and involved data from prescription registries, patient registries, and birth registries from Denmark, Finland, Iceland, Norway, and Sweden. Data from more than 1.6 million women included about 30,000 pregnant women who had filled a prescription for antidepressants known as selective serotonin reuptake inhibitors, or ... Read More

Four sisters file lawsuit against pregnancy drug claiming it cased them breast cancer

Four sisters have filed a lawsuit against Eli Lilly and Co., claiming that its drug DES, or diethylstilbestrol, taken by their mother during pregnancy to prevent miscarriage and preterm birth, caused them to develop breast cancer. The drug, a synthetic estrogen, was used during the 1930s through 1970s, but was eventually pulled from the market after it was found to be linked to rare vaginal cancer in women whose mothers used DES. All four Melnick sisters experienced miscarriages, fertility problems or other reproductive tract problems that were suspected to have been caused by prenatal exposure to DES. Each of the ... Read More

50th anniversary for Kefauver-Harris Amendment to ensure safer, more effective drugs

This year marks the 50th anniversary of the Kefauver-Harris Amendment, action that required drug companies provide more thorough data on the safety and efficacy of prescription drugs before they are approved. The amendment led to the development of evidence-based drug evaluations carried out by the Food and Drug Administration (FDA). Despite these efforts, some drug companies still try to withhold information on adverse drug reactions in order to bolster their own profits. Much of the credit for the passage of the Kefauver-Harris Amendment goes to Frances O’Kelsey. More than 50 years ago, when O’Kelsey was first hired to serve as ... Read More

SSRIs may inhibit pregnancy in women undergoing fertility treatments

Researchers are urging doctors to use extreme caution when prescribing a common class of antidepressants called selective serotonin reuptake inhibitors (SSRIs) to women who are attempting to become pregnant or during pregnancy. SSRIs – which include the brand names Zoloft, Paxil, Prozac, Lexapro and Celexa – may inhibit pregnancy in women undergoing fertility treatments, cause miscarriages and preterm births, and put developing fetuses at risk of birth defects. The information comes from a review of published studies of women with depressive symptoms who took antidepressants while pregnant. The review was published in the journal Human Reproduction. Researchers noted that as ... Read More

Systematic review of studies finds numerous problems with SSRI use during pregnancy

Women who took antidepressants while pregnant were more likely to miscarry, deliver prematurely, and to give birth to babies with developmental and health problems, according to a new systematic review of studies. The review focused on selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants in the United States. Brand names include Paxil, Zoloft, Celexa, Lexapro and Prozac. Researchers from Beth Israel Deaconess Medical Center in Waltham, Mass., noted that women who took SSRIs while pregnant were more likely to deliver their babies preterm. They were also more likely to develop high blood pressure that can lead to pre-eclampsia, ... Read More

Team of researchers says risks with SSRIs during pregnancy outweigh benefits

A team of researchers is recommending that women with past episodes of mild to moderate depression who are pregnant or are trying to get pregnant not take selective serotonin reuptake inhibitors (SSRIs), such as Zoloft, Paxil, Celexa and Prozac, because of risks to the unborn child. “There is no evidence of improved pregnancy outcomes with antidepressant use,” the researchers wrote in the journal Human Reproduction, adding that there are established downsides to using the drugs while pregnant such as an increased risk of miscarriage, preterm birth, and behavioral problems in newborns. The team of researchers from Boston IVF and Tufts ... Read More

Mother’s high blood pressure may lead to lower IQ in children

Children born to mothers who had high blood pressure while pregnant may be more likely to have a lower IQ later in life, according to new research. The findings resulted from a research project designed to look into what causes aging-related disorders and lower cognitive function in low birth weight newborns. Environmental factors during pregnancy can lead to low birth weight, and a risk factor of hypertension in women is low birth weight newborns, researchers say. High blood pressure during pregnancy can lead to a condition known as pre-eclampsia, which can be life threatening to both mother and her unborn child. The only ... Read More

Antidepressants during pregnancy linked to premature birth

Taking a certain antidepressant during pregnancy increases the risk of giving birth preterm, according to a study published in the journal Epidemiology. The study focused on a type of antidepressants known as serotonin reuptake inhibitors (SRI) including selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs). The difference between the two drugs is that SSRIs target the neurotransmitter of serotonin in particular, whereas SNRIs target the reuptake of other neurotransmitters besides serotonin, such as norepinephrine. The study focused on the SSRIs citalopram (Celexa), fluoxetine (Prozac), escitalopram (Lexapro), paroxetine (Paxil), and sertraline (Zoloft), and the SNRIs duloxetine (Cymbalta) and ... Read More