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proton pump inhibitors 102 articles

Guidelines provided to help patients taper off PPIs

Acid-reducing medicines proton pump inhibitors, or PPIs, are one of the most widely prescribed drugs, but the long-term effects have been linked to adverse events including Clostidium difficile infection, osteoporosis, pneumonia, vitamin deficiency, dementia, and chronic kidney disease. Weaning off prescription-strength dosages of PPIs even after taking them for just a few months can lead to rebound symptoms and dependency. Evidence shows that a “substantial number” people treated with these medications can effectively decrease or completely discontinue use of PPIs, as many are prescribed to patients without an appropriate reason. As a result, the journal Current Gastroenterology Reports published an ... Read More

PPIs linked to increased risk of death

Common heartburn medications called proton pump inhibitors, or PPIs, have been linked to a significantly higher risk of death than another common type of acid reducer, called H2 receptor antagonists, according to a five-year longitudinal cohort study published online in the journal BMJ Open. PPIs have been associated with a host of serious adverse events including acute interstitial nephritis, chronic kidney disease, incident dementia, and Clostridium difficile (C.diff) infection, all of which carry a higher risk of mortality. The team of researchers from St. Louise Health Care System set out to find whether PPI use is associated with excess death, ... Read More

Study links PPIs to major depressive disorder

A common class of heartburn medicines called proton pump inhibitors (PPIs) have been linked to depression in a new study published in the journal Psychotherapy and Psychosomatics. Researchers say that the pills may disrupt the gut’s bacteria, which can lead to major depressive disorder. The study, conducted by Wei-Sheng Huang from the Department of Psychiatry at the Taipei Veterans General Hospital in Taiwan, is the latest to suggest that a disruption of gastrointestinal bacteria can affect mental, emotional and physical wellbeing, and may explain why PPIs have been linked to a host of side effects from cancer to dementia to ... Read More

PPI users at risk of kidney damage without previous kidney injury

More than half of new proton pump inhibitors (PPIs) users develop chronic kidney damage while taking the heartburn medication without evidence of acute kidney injury prior to beginning PPI treatment, according to a study published in the journal Kidney International. PPIs are widely used and are available both by prescription and over-the-counter. Brand names include Prilosec, Prevacid and Protonix. PPIs reduce gastric acid secretions to treat heartburn and acid reflux. They are sometimes used to treat stomach ulcers. PPIs are known to increase the risk of acute kidney injury, acute interstitial nephritis, and chronic kidney disease. But it hasn’t been ... Read More

Pregnant women’s use of PPIs linked to asthma in children

Heartburn and pregnancy often go hand-in-hand, and medicines to reduce acid and help alleviate symptoms have long been thought to be safe for expectant mothers and their unborn children. But a new study suggests that a common type of acid reflux medication used during pregnancy may be linked to a three-fold increased risk of the woman’s child suffering from asthma. The study, recently published in the journal Pediatrics, involved data from more than 1.6 million participants. Researchers followed children born to women who took a proton pump inhibitor, or PPI, while pregnant. PPIs are sold by prescription as well as ... Read More

PPIs linked to liver disease

Proton pump inhibitors, or PPIs, are generally considered safe for reducing stomach acid and relieving heartburn. But the medication, readily available by prescription and over-the-counter, has been linked to serious side effects. Researchers from the University of California San Diego School of Medicine recently found that PPIs may cause changes to gut bacteria that can promote liver disease. They also linked PPI use along with alcohol abuse to liver damage. PPIs, known by the brand names Prilosec, Prevacid and Protonix, work by reducing gastric acid. But the absence of stomach acid promotes the growth of Enterococcus bacteria in the intestine, ... Read More

PPIs linked to kidney disease, kidney failure

Commonly used proton pump inhibitors (PPIs), sold by prescription and under brand names like Prilosec to treat heartburn and acid reflux, have been linked to an increased risk of kidney disease, according to a meta-analysis presented at the ASN (American Society of Nephrology) Kidney Week. The research, conducted by Charat Thongprayoon, M.D., from Bassett Medical Center, and colleagues, involved an analysis of published studies that reported the risk of kidney disease or kidney failure among PPI users compared to non-users. More than a half million participants from five different studies met the criteria for the meta-analysis. Researchers found that participants ... Read More

Study links PPIs to stomach cancer

Proton pump inhibitors (PPIs), one of the most commonly used drugs the U.S., have been linked to an increased risk of stomach cancer, according to new research conducted by the University College London. The new research backs earlier research that linked the drugs to stomach cancer in previous studies. The heartburn and acid reflux medication sold both by prescription as well as over the counter, is often taken for months – or even years – despite the recommended maximum time-frame of two to four weeks. The latest study found that people who took PPIs for two weeks were twice as likely ... Read More

PPI use linked to anxiety, depression

Proton pump inhibitors, or PPIs, are powerful acid-suppressing drugs sold both by prescription and over-the-counter to treat heartburn and gastroesophageal reflux disease (GERD), but they have also been linked to a long list of side effects. A new study published in a recent issue of the journal International Psychogeriatrics suggests that PPIs may also impact the brain, causing anxiety, nervousness and depression, especially in older adults. The study involved more than 300 elderly participants who answered questions about their mood as well as their use of a PPI, like omeprazole, known by the brand name Prilosec. Researchers found that participants ... Read More

Kidney disease: how what you’re consuming affects kidney health

Chronic kidney disease (CKD) is a worldwide epidemic. Twenty-six million American adults have CKD and millions of others are at increased risk. Kidney disease is the ninth leading cause of death in the U.S. The life-threatening disease is known to be associated with high blood pressure and diabetes. Because of its link to diabetes, researchers in the Netherlands decided to study the impact of diet on kidney function, as a diet rich in whole grains, fruits and vegetables has been associated with lower risk of diabetes. For five years, the researchers checked kidney function by monitoring the estimated glomerular filtration ... Read More