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Several patients sue Takeda over Actos injuries, cancer in Los Angeles

Fourteen people have filed a personal injury lawsuit against Takeda Pharmaceuticals alleging the its diabetes drug Actos (pioglitazone) caused them to develop bladder cancer. The lawsuit, filed in Los Angeles Superior Court, also names Takeda’s subsidiaries and Eli Lilly, which helped the Japan-based drugmaker market the blockbuster drug. According to the plaintiffs’ lawyers, the former Actos users claim the drug promoted the growth of bladder cancer and a number of related complications, including “permanent, severe and debilitating injuries, pain and suffering, and emotional distress.” As a result of the injuries allegedly brought about by Takeda’s “negligence, fraud and malice,” the ... Read More

Obese teen boys have radically low testosterone levels, study finds

It’s no mystery that obese teenage boys are at a heightened risk of developing diabetes and heart disease, but a new study published last week in the journal Clinical Endocrinology found that obese boys have alarmingly low testosterone levels as well – between 40 to 50 percent less than males of the same age with a normal body mass index (BMI). The study, conducted by researchers at the University of Buffalo, builds on earlier research the same scientists completed in 2004, which discovered low testosterone levels (hypogonadism) in older obese males ages 18 to 35, both diabetic and non-diabetic. Dr. ... Read More

Maryland man receives 5-year sentence for illegally distributing AndroGel

A Hagerstown, Maryland, man was sentenced to serve 366 days in a state prison Thursday after he pleaded guilty to illegally distributing AndroGel, a topical testosterone replacement drug made by Abbott Laboratories. According to the Herald-Mail, a Circuit Court Judge sentenced Timothy Allen Feigley, 33, to five years in state prison – the maximum sentence for distributing a Schedule III controlled dangerous substance, but suspended all but one year and one day. Mr.  Feigey also received credit for 139 days he already served. Additionally, Mr. Feigley will be put on probation or three years upon his release. The state dismissed ... Read More

Major League Baseball players suspended for testosterone drug use

“… as long as men and women play sports, they will look for whatever edge is available to them. Some legal. Some not so legal,” says ESPN writer Jason Stark about the use of synthetic testosterone to boost performance in professional sports. In August, San Francisco Giants left field Melky Cabrera and Oakland Athletics pitcher Bartolo Colon were suspended after testing positive for synthetic testosterone, which can mimic anabolic steroids if used in sufficient quantities. The suspensions prompted at least one Major League Baseball insider to warn of an epidemic of the performance enhancing drugs within the sport. Of course, ... Read More

Takeda faces Actos class-action in Quebec

MONTREAL, QUEBEC–A group of Actos patients from Quebec, Canada have filed a class action lawsuit against Takeda Pharmaceuticals and its affiliate Eli Lilly in an effort to collect damages for injuries they allege were brought about by the blockbuster diabetes drug. The latest Canadian lawsuit asserts that Japan-based Takeda and Indiana-based Eli Lilly knew about but failed to disclose critical safety information that the popular drug, used to treat patients with type 2 diabetes, promotes the development of bladder cancer. The Quebec patients involved in the new class action developed bladder cancer as a result of taking Actos, the lawsuit ... Read More

Antidepressant may be safer treatment for stress urinary incontinence

A drug used to treat depression may be a safer alternative for women with stress urinary incontinence (SUI) than some other treatments, according to a study published in the British Journal of Clinical Pharmacology. Duloxetine is approved by the Food and Drug Administration (FDA) to treat depression and general anxiety disorder, as well as pain and tingling caused by diabetic neuropathy, fibromylgia, and ongoing bone or muscle pain. It is in a class of medications called selective serotonin and norephinephrine reuptake inhibitors (SNRIs). It works by increasing the amount of serotonin and norepinephrine, natural substances in the brain that help ... Read More

UFC President voices approval for testosterone replacement therapy

Ultimate Fighting Championship (UFC) President Dana White told Fox Sports that testosterone replacement therapy (TRT) is “great” because it can help restore hormone levels in aging men. “Here’s the thing about TRT: It’s absolutely 100 percent legal,” Mr. White told Fox Sports. He explained, “As sports medicine continues to advance, this is one of those things where every guy’s testosterone level starts to drop as they get older and this is basically sports science now where they can bring it back up to a normal level. And I think it’s great, it’s absolutely fair, it’s legal. “The problem is, there ... Read More

Researchers to test Actos as potential Alzheimer’s treatment

Takeda’s controversial diabetes drug Actos could soon be used to treat patients at high risk of developing Alzheimer’s disease, opening the drug to an entirely new customer base beyond diabetic patients. Previous research has established a link between decreased glucose utilization in the brain and Alzheimer’s disease. Actos (pioglitazone) is used to regulate glucose (blood sugar) in the body by making cells more sensitive to insulin – a natural hormone that stabilizes blood sugar levels. Only recently have researchers discovered that Actos taken by diabetic patients reaches the brain. Expanding on that knowledge, researchers with Takeda and Zinfandel Pharmaceuticals used ... Read More

Study finds many men can restore testosterone levels with diet and exercise

Doctors should encourage overweight, middle-aged, and pre-diabetic men to lose weight through diet and exercise before putting them on testosterone replacement therapy, says the author of a new study presented at the a Houston medical conference. Dr. Frances Hayes, a professor at St. Vincent’s University Hospital in Dublin, Ireland, said that men who suffer from low testosterone levels can restore their hormones by nearly 50 percent by adhering to a healthier, more active lifestyle. The study monitored 900 American men with an average age of 54 who had been diagnosed with impaired glucose tolerance, or pre-diabetes. The men, all of ... Read More

Another new study finds Actos elevates bladder cancer risk

A new Canadian analysis of previously completed Actos studies has linked Takeda’s blockbuster diabetes drug to an increased risk of bladder cancer yet again. Jeffrey A. Johnson, the Canada Research Chair in Diabetes Health Outcomes at the University of Alberta’s School of Public Health and the study’s senior author, told HealthDay News the analysis found Actos (pioglitazone), used to treat type 2 diabetes, is associated with a 22 percent increased risk of developing bladder cancer. According to Dr. Johnson, it’s not known precisely how Actos elevates the bladder cancer risk, but some studies suggest the drug may cause crystals to ... Read More