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Restless Leg Syndrome 7 articles

Long-term quinine use increases death risk

People treated for a year with quinine for leg cramps or restless leg syndrome are at an increased risk of dying, according to research published in the Journal of the American Medical Association. Quinine has been prescribed since the 1940s for leg cramps. But in 2006, the Food and Drug Administration (FDA) banned its use in the U.S., only permitting the brand name version of the drug, Qualaquin, for the treatment of malaria. Doctors can prescribe medications for conditions for which they are not approved. But the FDA warned that quinine has been linked to serious side effects and death and ... Read More

Parkinson’s, RLS drug possibly linked to heart failure

Mirapex (pramipexole), a drug used to treat symptoms of Parkinson’s disease and moderate to severe restless legs syndrome (RLS), may be linked to an increased risk of heart failure, according to a safety advisory issued by the Food and Drug Administration (FDA). Recent studies have suggested the potential for heart failure but the data is limited, thus the FDA says more review is needed before a definite risk can be established. The warning is based on a pooled analysis of randomized clinical trials that found heart failure was more frequent with Mirapex than with placebo; however, the results were not ... Read More

FDA warns doctors, pharmacists to be aware of possible drug mix-up

A common drug mix-up has caused some people to be hospitalized and has prompted the Food and Drug Administration (FDA) to issue a warning to doctors and pharmacies to be sure their patients are being given the correct medication. The drugs involved in the mix-up include risperidone (Risperdal), an antipsychotic medication used to treat mental illnesses such as schizophrenia, bipolar disorder, and irritability associated with autistic disorder; and ropinirole (Requip), a dopamine agonist used to treat Parkinson’s disease and restless leg syndrome. Not only has risperidone been mistaken for ropinirole, but ropinirole has been mistaken for risperidone. The FDA has ... Read More

Darvon, Darvocet may have caused more deaths than any other painkiller

Before it was removed from the market late last year, Darvon, Darvocet and other painkillers containing propoxyphene were considered by some professionals as having caused more deaths annually than any other drug. It is listed by the U.S. Drug Enforcement Agency as one of the country’s top ten abused drugs, and was banned in the United Kingdom and Europe for years before the United States followed suit. At the time it was pulled from the U.S., an estimated 20 to 40 million prescriptions were written for the drug every year for the past 50 years. The bottom line – propoxyphene-containing ... Read More

Restless leg syndrome turns out to be movement disorder caused by Reglan

PHOENIX, ARIZONA – Ron, a musician and artist, was having trouble sleeping. His legs would move involuntarily back and forth under the sheets. At first, both Ron and his doctors thought he suffered from restless leg syndrome. But after a battery of tests conducted by neurologists, and a review of his medical history and medications, doctors determined that Ron suffered from a Parkinson’s-like condition known as Tardive Dyskinesia. They say it was caused by the heartburn medication Reglan. Reglan, also known by the generic metoclopramide, is a prescription medication used to treat severe heartburn, acid reflux, gastroparesis and other gastrointestinal ... Read More

FDA warns against use of malaria drug for restless leg syndrome

The Food and Drug Administration (FDA) has approved a Risk Evaluation and Mitigation Strategy plan for the malaria drug Qualaquin (quinine sulfate) to warn against unapproved uses. The plan warns health care professionals and consumers not to use Qualaquin to treat night time leg cramps or restless leg syndrome, because such use has resulted in serious side effects and even death. Qualaquin is approved by the FDA to treat uncomplicated malaria caused by the parasite Plasmodium falciparum, which can be life-threatening if untreated. The drug is sometimes prescribed for restless leg syndrome though that use is not approved by the ... Read More

FDA warns about qualaquin use for restless leg syndrome

The Food and Drug Administration (FDA) has issued a warning to health care professionals to use extreme caution when prescribing Qualaquin (Quinine Sulfate), according to the Postmarket Reviews section of the Volume 2, Number 2 2, 2009 issue of its quarterly online newsletter, Drug Safety News (DSN). Qualaquin is approved by the FDA for the treatment of uncomplicated Plasmodium falciparum malaria, a disease rarely found in the U.S. However, drug use data indicates that many prescriptions written for quinine sulfate in the U.S. are for the treatment of nocturnal leg cramps or Restless Leg Syndrome, both of which are off-label ... Read More