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rheumatoid arthritis 19 articles

Long-term use or high doses of RA drug increases diabetes risk

The likelihood of a patient developing type 2 diabetes while on rheumatoid arthritis (RA) medication known as glucocorticoids increases in relation to the dosage, duration and timing of steroids, according to a new study published in the journal Arthritis and Rheumatology. Glucocorticoid therapy is prescribed to about half of all patients with rheumatoid arthritis, a chronic inflammatory disorder affecting many joints including those in the hands and feet. Diabetes is a side effect of glucocorticoids. The medication has been used since 1948 to treat flare-ups in joint pain. It is also used for longer periods at low doses to help ... Read More

Mylan recalls injectable cancer, psoriasis, rheumatoid arthritis drugs

Injectable drugs to treat various cancers, severe psoriasis, and rheumatoid arthritis are being recalled by Mylan N.V. because particles were found floating in some retention samples during testing, posing a serious risk to patients. The Mylan recall affects Gemcitabine for injection, USP 200mg; Carboplatin Injection 10mg/mL; Methotrexate injection, USP 25mg/mL; and Cytarabine injection. Gemcitabine is a treatment for ovarian cancer, breast cancer, non-small cell lung cancer and pancreatic cancer. Carboplatin is used to treat advanced ovarian carcinoma. Methotrexate is administered intramuscularly, intravenously, intra-arterially, or intrathecally to treat certain neoplastic diseases, severe psoriasis and adult rheumatoid arthritis. If a sterile injectable product ... Read More

Bone marrow treatment restores hair growth in patients with alopecia

Clinical trials on FDA-approved drugs for other conditions have been shown to restore hair growth in some patients with alopecia areata, an autoimmune disease that causes hair loss. Researchers at Columbia University Medical Center have identified the immune cells responsible for destroying the hair follicles in people with alopecia, and set out to test FDA-approved drugs that would eliminate these immune cells to see if they would restore hair growth in patients. Alopecia is a common autoimmune disease that can occur at any age. Hair is often lost in patches on the scalp, but in some cases patients can have ... Read More

FDA panel split on heart risks with non-steroidal anti-inflammatory drugs

Two Food and Drug Administration (FDA) advisory committees were split on whether data from an analysis of multiple clinical trials showed an increased risk of cardiovascular events in people using common painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs). The FDA’s Arthritis Advisory Committee and Drug Safety and Risk Management Advisory Committee met jointly to review data and determine whether naproxen was less dangerous to the heart than other NSAIDs such as ibuprofen and Celebrex, as the journal The Lancet suggested. Naproxen is sold as a prescription drug under the name Naprosyn and over-the-counter under the brand name Aleve. Ibuprofen is ... Read More

Smoking-related COPD takes life of Marlboro Man

Another Marlboro Man has died from a smoking-related disease. Eric Lawson, one of several rugged-looking men paid by the tobacco company Phillip Morris to represent the company’s Marlboro cigarette brand, died of chronic obstructive pulmonary disease (COPD) on January 10. He was 72. Lawson was not only a spokesman for Marlboro, he even smoked the cigarettes – as many as three packs a day. By the 1990s, he saw the error of his ways, and spoke of the hazards of cigarette smoking in public service announcements for the American Cancer Society. Yet, even Lawson couldn’t shake the habit, and continued ... Read More

Surgeon general report: More serious, deadly diseases linked to tobacco use

Fifty years since the surgeon general warned that cigarette smoking could have deadly health consequences, resulting in a decades-long effort to place tighter restrictions on the sale and use of tobacco products, more health problems have been linked to tobacco use. Smoking can cause liver cancer, colorectal cancer, type 2 diabetes, age-related macular degeneration, erectile dysfunction and rheumatoid arthritis, according to a report by Acting Surgeon General Boris D. Lushniak. Smoking can also worsen asthma, cause cleft lips and palates in developing fetuses, and cause strokes in non-smokers exposed to second-hand smoke, the report states. And, due to changes in ... Read More

FDA proposes stricter guidelines for widely prescribed painkiller hydrocodone

Proposed new guidelines for painkillers aims to put drugs containing hydrocodone, such as Lortab and Vicodin, in the same category as potent opioids like Oxycontin and morphine. The Food and Drug Administration’s (FDA) recommendation for the highly addictive class of painkillers must first be approved by other Health and Human Service Department officials before it can go into effect. The major policy change comes more than a decade after the Drug Enforcement Administration (DEA) first asked that hydrocodone-containing drugs be more restricted. Hydrocodone drugs are the most widely prescribed medications in the country, with more than 131 million prescriptions written ... Read More

Hepatitis B reactivation warnings added to drugs Arzerra, Rituxan

The Food and Drug Administration (FDA) announced new black box warnings for potentially fatal reactivation of hepatitis B viruses (HBV) were added to two drugs – one an immune suppressant and the other an anti-cancer medication. The warnings will be added to the labels of Arzerra (ofatumumab) and Rituxan (rituximab). Arzerra is used to treat chronic lymphocytic leukemia (CLL) in patients who have further disease after treatment with the anti-cancer drugs fludarabine and alemtuzumab. Rituxan is used to treat non-Hodgkin’s lymphoma and CLL. It is also used to treat other medical conditions, including rheumatoid arthritis, granulomatosis with polyanglitis, and microscopic ... Read More

Chemotherapy drugs recalled due to glass particles in vials

Hospira Inc. is recalling certain lots of injectable chemotherapy drugs because the vials may be contaminated with tiny particles that can be inadvertently injected into patients, which could cause serious health problems that require immediate medical intervention. The recalled drugs include Carboplatin, Cytarabine, Paclitaxel, and Methotrexate, which are distributed packaged in vials and used to treat various types of cancer. In addition, Methotrexate is also used to treat psoriasis and rheumatoid arthritis. The products were distributed nationwide. The recall affects 19 lots of the drugs and was ordered due to visible particles embedded in the glass located at the neck ... Read More

FDA panel considers benefits, risks of experimental rheumatoid arthritis drug

Drug regulators are questioning whether an experimental drug for rheumatoid arthritis has too great of a cancer risk and whether it actually works as well as the drug company claims. The drug, tofacitinib, marketed by Pfizer, is under review by a Food and Drug Administration (FDA) advisory panel, which will vote whether to recommend the treatment for FDA approval. The FDA isn’t required to follow the advice of its expert panels, but it usually does. Analysts have pegged tofacitinib as a potential blockbuster medication. “Blockbuster drugs” are ones that generate at least $1 billion in revenue for their owner over ... Read More