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risk factors 15 articles

Cancer drug Avastin with chemo granted priority review for treatment of ovarian cancer

The Food and Drug Administration (FDA) has granted Priority Review status for the cancer drug Avastin (bevacizumab) plus chemotherapy for the treatment of women with recurrent platinum-resistant ovarian cancer. Avastin is already approved to treat specific types of colorectal, lung, kidney, and brain cancers. Avastin was also granted priority review for the treatment of cervical cancer. The Priority Review status is based on data from the Phase 3 AURELIA trial, a multicenter, randomized, open-label study in 361 women with platinum-resistant recurrent epithelial ovarian, primary peritoneal or fallopian tube cancer who have received no more than two anticancer regimens prior to ... Read More

Young adults who were treated with growth hormones as children may be at greater risk for stroke

People who received growth hormones as children to treat short stature or hormone deficiency should be aware that they are at an increased risk of stroke caused by burst blood vessels when they become young adults, a team of French and British researchers say. The warning is based on findings from a study published in this week’s issue of the journal Neurology, and applies also to people who misuse the growth hormones to improve athletic performance, for body building and other “questionable reasons.” Growth hormones were approved in the United States in the mid-1980s to treat pituitary gland problems and to ... Read More

Pancreatic cancer research grows as cases of the disease increase

Several organizations and philanthropies are banding together to find more effective treatments for pancreatic cancer, one of the most deadly forms of the disease. Entertainment industry’s Stand Up to Cancer (SU2C) initiative, family philanthropies, the advocacy group Pancreatic Cancer Action Network (PanCan), and the PanCan-inspired federal “recalcitrant cancer” law are making it possible for medical centers to test chemotherapies, targeted therapies, immunotherapies and other treatments for pancreatic cancer patients. Pancreatic cancer has a 6 percent five-year survival rate and is the fourth leading cause of cancer related-deaths. However, cases of the disease are growing, and experts say the disease will ... Read More

Waistline measurement can indicate type 2 diabetes risk

Want to know if you are at risk for type 2 diabetes? Then whip out your tape measure, says Public Health England. Waistlines larger than 40 inches in men or 35 inches in women indicate a “very high risk” of developing the chronic disease, the agency warns. Men with a 40-inch waist are five times more likely to develop type 2 diabetes and women with 35-inch waistlines were three times more likely to develop the disease compared to those with slimmer waistlines. Even waistlines three to four inches smaller than 40 or 35 inches for men and women, respectively, puts ... Read More

Study links high cholesterol to breast cancer

Controlling high cholesterol may help prevent breast cancer, a new study shows. However, current medications that help lower cholesterol levels could lead to other health issues. Researchers at the Aston University School of Medicine Sciences in Birmingham, England, reviewed medical records of more than 660,000 female patients between 2000 and 2013, and found a connection between high cholesterol and breast cancer. From this, researchers determined that high cholesterol increases a woman’s risk of developing breast cancer by nearly two thirds. Obesity can be a contributing factor for breast cancer, and researchers say that may be because high cholesterol and obesity ... Read More

New chemotherapy treatment extends metastatic pancreatic cancer survival by nearly 2 months

Metastatic pancreatic cancer patients treated with Merrimack Pharmaceuticals’ experimental chemotherapy drug MM-398 in combination with the cancer drugs 5-fluorouracil (5-FU) and leucovorin survived nearly two months longer than patients treated with only 5-FU and leucovorin, the Pancreatic Cancer Action Network announced. The results come from the NAPOLI-1 phase III study, which involved three participant groups, each made up of patients with metastatic pancreatic cancer who had been previously treated with gemcitabine (Gemzar) -based chemotherapy. Participants were treated with either 5-FU and leucovorin, or a combination of MM-398 with 5-FU and leucovorin. (5-FU and leucovorin are a standard treatment option for metastatic ... Read More

Study: Acute pancreatitis greatly increases risk of pancreatic cancer

People diagnosed with acute pancreatitis are more likely to develop pancreatic cancer, according to a new study published in the journal Clinical Gastroenterology and Hepatology. Previous studies have shown a higher incidence of pancreatic cancer in patients diagnosed with acute pancreatitis, however it was unknown the rate that acute pancreatitis precedes a diagnosis of pancreatic cancer and the time between the two diagnoses. “Our study demonstrates that there is a much higher risk of pancreatic cancer in patients with acute pancreatitis than commonly believed,” said principle investigator Banke Agarwal, MD, associate professor of gastroenterology and hepatology at St. Louis University. Researchers ... Read More

FDA warning: Cardiac implant can seriously damage heart

The Food and Drug Administration (FDA) issued a warning that a cardiac implant used in children and adults to treat an abnormal hole between the left and right chambers of the heart known as an atrial septal defect (ASD) can break down and cause life-threatening emergencies that require immediate surgery. The FDA warned that in rare cases, the St. Jude Amplatzer Septal Occluder can rub against the wall of the heart and can erode the tissue and create a hole. It can also lead to further scraping or erosion through tissue in the upper chambers (atria) of the heart, primarily ... Read More

SSRIs may not increase stillbirth, infant death, but still carry birth defect risk

The most widely prescribed class of antidepressants, if taken during pregnancy, do not increase the risk of stillbirth or newborn death, a new study suggests. However, several studies have shown that the drugs can cause birth defects, premature birth, and other problems. The lastest study was published in the Journal of the American Medical Association (JAMA) and involved data from prescription registries, patient registries, and birth registries from Denmark, Finland, Iceland, Norway, and Sweden. Data from more than 1.6 million women included about 30,000 pregnant women who had filled a prescription for antidepressants known as selective serotonin reuptake inhibitors, or ... Read More

Complaints allege Fresenius withheld information about deaths to minimize legal risks, keep market share

Fresenius Medical Care, the world’s largest provider of dialysis services and products, is facing numerous wrongful death lawsuits claiming one of its products caused the deaths of dialysis patients. The company is fighting back, claiming it was not at fault. But sources say top management at Fresenius knew its dialysate product GranuFlo was contributing to serious health problems including deaths in patients but withheld this information in order to maintain the company’s market share as well as to minimize and diffuse its legal risks. Dialysates, such as GranuFlo, are solutions used to clean the blood during hemodialysis. GranuFlo is the ... Read More