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risperidone 76 articles

Metformin helps reduce weight in children with autism treated with antipsychotics

The commonly prescribed type 2 diabetes drug metformin is effective at reducing weight in overweight children and adolescents with autism spectrum disorder, and is especially true in children who take antipsychotic medication to treat their condition, according to a new study published in the Journal of the American Medical Association (JAMA). Children with autism are about twice as likely to be obese compared to adolescents without developmental disabilities, according to the Centers for Disease Control and Prevention (CDC). Two medications are approved to treat irritability with autism in children – risperidone (Risperdal) and aripiprazole (Abilfy). Both medications can cause significant ... Read More

Higher doses of antipsychotic risperidone causes more severe prolactin-related symptoms

Smaller dosages of the antipsychotic drug risperidone reduced the severity of prolactin-related symptoms, suggesting a need to track the hormone’s levels in patients who use the drug long-term, according to a study published in the journal BMC Psychiatry. Risperidone, sold under the brand name Risperdal as well as generically, is approved to treat adults and children with schizophrenia, bipolar disorder, and irritability with autism. It is often prescribed off-label for other behavioral conditions including ADHD. The treatment can cause weight gain in patients, putting them at risk for type 2 diabetes. It can also increase levels of prolactin. Prolactin is a hormone ... Read More

Metformin helps autistic kids taking antipsychotics lose weight

Children treated with the antipsychotic drug Risperdal to treat symptoms of autism are at risk of weight gain, which causes metabolic changes and increases their chances of developing type 2 diabetes. But taking the frontline diabetes drug metformin along with the antipsychotic can dramatically help kids shed those extra pounds, a new study shows. The study, published in JAMA Psychiatry, was the first to look at the treatment and prevention of weight gain in children with autism spectrum disorder. Metformin has been studied for the general treatment of weight gain in children, and has been shown to stop weight gain in ... Read More

Antipsychotic prescriptions for pediatric patients increasing

Prescriptions for antipsychotic medications written for children and adolescents has grown significantly in recent years, and two thirds of them are written for off-label indications, raising questions about whether the use of these drugs among children is appropriate. “It’s concerning that such a high proportion of pediatric patients were taking AAPs (atypical antipsychotic drugs) off-label, and that a number of children are exposed to AAP side effects such as metabolic syndrome and diabetes, while the drugs’ effectiveness on their psychiatric condition may not have been well established,” said Minji Sohn, PhD, co-author of analysis of outpatient data from the National ... Read More

Some second-generation antipsychotic drugs more likely to cause weight gain

The second-generation antipsychotic drugs risperidone, aripiprazole and olanzapine, used to treat irritability in adults and children with autism, are more likely to cause weight gain than others, according to a study published in the Journal of Child and Adolescent Psychopharmacology. Several antipsychotics have been approved to treat irritability with autism, which includes behaviors such as aggression, self-injury and severe tantrums. But risperidone, aripiprazole and olanzapine are more likely to cause changes in glucose and lipid metabolism, weight gain, and poor cardiovascular outcomes. Risperidone, known by the brand name Risperdal, can also increase levels of the prolactin, the hormone that causes pregnant women ... Read More

Children may have long lasting side effects from Risperdal, other antipsychotic drugs

Medicating children with antipsychotic medication for behavior problems could have a significant lifelong implications on their levels of hyperactivity, depression and anxiety, a new study has found. Treating children with antipsychotics can be a difficult balancing act when it comes to treating symptoms of severe psychosis, such as schizophrenia, but antipsychotic side effects can sometimes outweigh the benefits. Researchers with the University of Wollongong published the initial results of the first comprehensive study investigating the long-term effects of three commonly prescribed antipsychotics – risperidone (Risperdal), olanzapine (Zyprexa) and aripiprasole (Abilify) – on children. Treating children with these powerful drugs is a ... Read More

Lawsuit claims drug company withheld Risperdal side effects data

Johnson & Johnson and its subsidiary Janssen Pharmaceuticals took measures to limit the medical community’s knowledge of side effects in children with its antipsychotic drug Risperdal, according to a lawsuit waged against the drug companies by the family of a Tennessee boy who was allegedly harmed by the drug. Andrew Yount’s lawsuit is the fifth among nearly 1,750 Risperdal side effects cases pending in Philadelphia to go to trial. The lawsuits claim that Johnson & Johnson withheld data showing that Risperdal could cause female breast growth in adolescent boys, a condition known as gynecomastia. Yount’s lawsuit claims that he was ... Read More

Latest Risperdal side effects lawsuit settles

The latest Risperdal side effects lawsuit set for trial has settled for an undisclosed amount, but that doesn’t mean a global settlement is expected anytime soon in the mass tort program. Nearly 1,800 people are suing Johnson & Johnson and its subsidiary Janssen Pharmaceuticals alleging its antipsychotic Risperdal caused adolescent boys to grow female breasts, a condition known as gynecomastia. Four Risperdal lawsuits have gone to trial. The fifth, Moffat v. Janssen Pharmaceuticals, settled May 13, four days after it was slated to go to trial. The Moffat case was not the first to end in a settlement. In May ... Read More

Risperdal side effects especially worrisome in children

The antipsychotic drug Risperdal (risperidone) can successfully reduce serious behavioral problems in children with autism spectrum disorder, but it comes at a price. Risperdal can increase appetite, causing children to gain weight rapidly, leading to insulin resistance predisposing them to diabetes, cardiovascular disease and liver disease, according to research published in the Journal of the American Academy of Child and Adolescent Psychiatry. The study, led by Lawrence Scahill, MSN, PhD, professor of pediatrics at Emory University School of Medicine and Marcus Autism Center, involved children ages 4 to 13 with autism and serious behavioral problems. The children were randomized to receive ... Read More

‘Independent’ reanalysis of study funded by Risperdal makers

Findings of a medical paper that understated claims regarding side effects with the antipsychotic Risperdal – specifically that the medication can cause adolescent boys to grow breasts – were upheld by a so-called independent reanalysis, which was later found to have been funded by the manufacturers of the drug. During a Risperdal side effects trial against Johnson & Johnson and its subsidiary Janssen Pharmaceuticals last year, after which a jury found in favor of the plaintiff, attorneys found internal records that showed Janssen had spearheaded the study, even instructing researchers to “refute the results” of the controversial findings. Risperdal, known ... Read More