Tagged Articles

selective serotonin reuptake inhibitors 83 articles

50th anniversary for Kefauver-Harris Amendment to ensure safer, more effective drugs

This year marks the 50th anniversary of the Kefauver-Harris Amendment, action that required drug companies provide more thorough data on the safety and efficacy of prescription drugs before they are approved. The amendment led to the development of evidence-based drug evaluations carried out by the Food and Drug Administration (FDA). Despite these efforts, some drug companies still try to withhold information on adverse drug reactions in order to bolster their own profits. Much of the credit for the passage of the Kefauver-Harris Amendment goes to Frances O’Kelsey. More than 50 years ago, when O’Kelsey was first hired to serve as ... Read More

Lexapro may be effective in treating symptoms of menopause

The antidepressant escitalopram, known by the brand name Lexapro, was effective in decreasing hot flash frequency and severity in menopausal women, according to a small clinical trial. Lexapro is in a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is approved to treat depression and generalized anxiety disorder, and excessive worry and tension that lasts for 6 months or longer. Other brand-name antidepressants in the SSRI class include Paxil, Zoloft, Celexa, and Prozac. The study was conduced in 2009 and has not resulted in the drug’s maker seeking approval for the new indication. However, some doctors prescribe ... Read More

Systematic review of studies finds numerous problems with SSRI use during pregnancy

Women who took antidepressants while pregnant were more likely to miscarry, deliver prematurely, and to give birth to babies with developmental and health problems, according to a new systematic review of studies. The review focused on selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed antidepressants in the United States. Brand names include Paxil, Zoloft, Celexa, Lexapro and Prozac. Researchers from Beth Israel Deaconess Medical Center in Waltham, Mass., noted that women who took SSRIs while pregnant were more likely to deliver their babies preterm. They were also more likely to develop high blood pressure that can lead to pre-eclampsia, ... Read More

Studies reveal risks, help women make informed decisions about taking SSRIs during pregnancy

Janice Price, 37, is waiting for answers. The 37-year-old woman has wanted to start a family with her husband for at least two years. But she is taking an antidepressant and worries about studies that have linked antidepressant use during pregnancy to problems for both the expectant mother and her unborn child. Recent studies have shown that pregnant women who take a common type of antidepressant known as selective serotonin reuptake inhibitors (SSRIs) have an increased risk of developing high blood pressure that can lead to pre-eclampsia, a condition that can be life threatening to both mother and the fetus. ... Read More

Team of researchers says risks with SSRIs during pregnancy outweigh benefits

A team of researchers is recommending that women with past episodes of mild to moderate depression who are pregnant or are trying to get pregnant not take selective serotonin reuptake inhibitors (SSRIs), such as Zoloft, Paxil, Celexa and Prozac, because of risks to the unborn child. “There is no evidence of improved pregnancy outcomes with antidepressant use,” the researchers wrote in the journal Human Reproduction, adding that there are established downsides to using the drugs while pregnant such as an increased risk of miscarriage, preterm birth, and behavioral problems in newborns. The team of researchers from Boston IVF and Tufts ... Read More

SSRIs may increase stroke risk

Taking the most common type of antidepressant can increase the risk of certain types of strokes, according to a study published in the journal Neurology. The new research builds on previous studies that linked use of selective serotonin reuptake inhibitors (SSRIs) to major bleeding, such as gastrointestinal bleeding. SSRIs include brand name drugs Zoloft, Paxil, Lexapro and Prozac. SSRIs are thought to inhibit the clumping together of platelets, which could cause internal bleeding. The new study focused on antidepressant use and stroke. Canadian researchers analyzed 16 studies and found that of the combined 500,000 participants, those taking SSRIs were 51 ... Read More

Antidepressants during pregnancy may affect babies’ language comprehension

A new study suggests that babies born to women who take selective serotonin reuptake inhibitors (SSRIs) during pregnancy to treat depression may be better able to grasp and understand sights and sounds of language. However, previous studies have shown that the drugs can put babies at risk for serious birth defects, prematurity, learning difficulties, developmental delays, behavioral problems, and autism. The new study was conducted by researchers from the University of British Columbia, Harvard University and the Child & Family Research Institute, and focused on babies born to pregnant women who suffered from depression. Some of the women took SSRIs, ... Read More

Antidepressants may increase risk for type 2 diabetes

People who use antidepressants may be at greater risk for developing type 2 diabetes, according to a new study published in Diabetologia. Researchers at Harvard School of Public Health conducted a meta-analysis and determined that antidepressants are associated with a 68 percent increased risk for developing the disease, after adjustment for age. Previous studies have suggested a link; the meta-analysis is based on three cohorts of U.S. adults – Health Professionals Follow-Up Study (HPFS), Nurses’ Health Study I (NHS I), and Nurses’ Health Study II (NHSII). A total of nearly 170,000 participants were involved. At baseline, all participants did not ... Read More

Antidepressants among the most prescribed drugs in 2011

Antidepressants were the seventh most prescribed drugs in 2011, with the psychiatric drugs Xanax, Zoloft and Celexa leading the pack, according to the journal ACS Chemical Neurosciences. While sales of all antidepressants dropped from $11.6 billion in 2010 to $11 billion in 2011, some experts say the use of antidepressants in America is excessive and could be causing more problems for some. Pfizer’s cholesterol drug Lipitor ranked No. 1 in pharmaceutical sales in the United States, with a whopping $7.7 billion in revenue. Bristol-Myers Squibb’s antipsychotic Ability ranked No. 4 with $5.2 billion in sales. Both Zoloft and Celexa are ... Read More

Company apologizes for birth defects caused by drug given to pregnant women

German drug maker Gruenenthal Group is apologizing to women who took its morning sickness medication Thalidomide in the 1950s and 1960s, and to their children who suffered congenital birth defects as a result. The apology comes 50 years after the drug was pulled off the market for causing babies to be born with shortened arms and legs or with no limbs at all. “We ask that you regard our long silence as a sign of the shock that your fate caused in us,” said Harald Stock, Gruenenthal Group’s chief executive, during an unveiling of a statute in the drug company’s ... Read More