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side effects 620 articles

Number of drug side effects reports skyrocketing in recent years

The Food and Drug Administration (FDA) received a record number of adverse event reports about drug side effects and problematic medical devices for 2015, representing a fivefold increase since 2004, according to an analysis by the Milwaukee Journal Sentinel and MedPage Today. In 2004, 206,000 drug or medical device adverse events were reported to the FDA. In 2015, that number jumped to 1.5 million. Reports ranged from mild effects such as gas and flatulence to serious injuries and death. Most of the side effects reported involved drugs that treat diseases such as rheumatoid arthritis, psoriasis, multiple sclerosis, a type of cancer, and ... Read More

Study: side effects of weight loss drug orlistat grossly underreported

Only a fraction of side effects associated with the obesity drug orlistat, sold as the prescription drug Xenical and the over-the-counter medicine Alli, were published in papers and summarized clinical study reports submitted to the European Medicines Agency (EMA), according to a study conducted by researchers with the Nordic Cochrane Centre in Copenhagen. The study used the Freedom of Information Act to acquire clinical study reports from the EMA that included seven randomized placebo-controlled trials of orlistat involving 4,225 patients. The data was reviewed by drug regulators in both the U.K. and the U.S., who voted to approve Xenical in ... Read More

Californians Demanding End To Irrigating Crops With Industrial Wastewater

A group of Californians concerned about their state’s growing practice of allowing industrial wastewater to irrigate hundreds of farms gathered outside the state capitol building in Sacramento August 9 to deliver a wheelbarrow full of petitions urging an immediate halt to the practice. The 350,000 petition signatures were collected by CREDO, Care2, Food & Water Watch, the Center for Biological Diversity, RootsKeeper, Center for Environmental Health, Breast Cancer Action, Center for Food Safety, Courage Campaign, and the Center for Race, Poverty and the Environment. The petition urges Governor Jerry Brown and the California Water Resources Board to stop allowing Chevron ... Read More

Antipsychotic prescriptions for pediatric patients increasing

Prescriptions for antipsychotic medications written for children and adolescents has grown significantly in recent years, and two thirds of them are written for off-label indications, raising questions about whether the use of these drugs among children is appropriate. “It’s concerning that such a high proportion of pediatric patients were taking AAPs (atypical antipsychotic drugs) off-label, and that a number of children are exposed to AAP side effects such as metabolic syndrome and diabetes, while the drugs’ effectiveness on their psychiatric condition may not have been well established,” said Minji Sohn, PhD, co-author of analysis of outpatient data from the National ... Read More

Study: Patients with schizophrenia fare better with fewer meds, more therapy

Patients with schizophrenia who were given smaller doses of antipsychotic drugs along with individual talk therapy and family support fared far better than patients who got the usual drug-focused care, a new landmark study has found. More than two million people in the United States are diagnosed with schizophrenia. Treatment typically involves high doses of antipsychotic drugs, such as Risperdal, in order to quell hallucinations and delusions. But the side effects can be brutal. Antipsychotic drugs can cause weight gain, diabetes, and debilitating movement disorders. Risperdal, one of the few schizophrenia treatments approved for children and adolescents, has also been ... Read More

Risks may out weigh benefits of statins in elderly

Seniors are nearly four times more likely to be prescribed cholesterol-lowering statins than they were in 1999, and in many cases the drugs are being prescribed to the elderly who have no signs of heart disease, exposing them to potentially serious statin side effects. Statins are among the most prescribed drugs in the world. They are designed to drive down high cholesterol levels to help prevent heart attacks, strokes and cardiovascular-related deaths. New guidelines have dramatically expanded by millions the number of patient who are now eligible to take the drugs. The guidelines offer a “risk calculator” to figure a ... Read More

FDA warns of serious side effects with wrinkle fillers

Soft tissue fillers, also known as dermal fillers, facial implants or wrinkle fillers, injected into skin on the face to smooth wrinkles can cause rare but serious side effects if unintentionally injected into blood vessels in the face, the Food and Drug Administration (FDA) warns. Unintentional injection can block blood vessels and restrict blood supply to tissues which can result in embolization, meaning that the filler material has traveled to other parts of the body. Side effects include vision impairment, blindness, stroke, damage and/or death to the skin (necrosis) and underlying facial structures. While unintended injections into blood vessels may ... Read More

Adverse events linked to misuse of IV training solutions

Numerous patients have fallen ill and one died after receiving infusions of saline products intended for training purposes and not for human use, the Centers for Disease Control and Prevention (CDC) reported. The products involve Wallcur’s simulated intravenous (IV) saline solutions, which were inadvertently distributed to medical clinics, surgical centers and urgent care facilities in numerous states. More than 40 patients were injected with the IV training solutions, and many experienced adverse events including fever, chills, tremors and headaches. Some patients were hospitalized, and one death has been associated with use of the product though the CDC says it is ... Read More

Book links Lipitor to memory problems, dementia

Cholesterol-lowering statin drugs, such as the widely prescribed Lipitor, may gradually degrade the brain by depriving it of cholesterol, causing memory problems, dementia and other cognitive problems, according to the book Lipitor: Thief of Memory. The book, written by Dr.Duanne Graveline, M.D., chronicles the former astronaut and aerospace medical research scientist’s own horrific experience with statins and how he says the drugs caused him to suffer two transient global amnesia events and chronic neuropathy. Graveline’s theory is also explained by his good friend Dr. David Brownstein, who wrote in a blog about how statins work by poisoning an enzyme known ... Read More

FDA to push drugmakers to provide latest drug safety information electronically

Pharmaceutical companies must provide health care providers with the latest available drug safety information via real-time electronic updates, according to a new rule proposed by the Food and Drug Administration (FDA). “This would ensure that the most up-to-date version of the prescribing information is available to health care professionals and the public,” the rule states. The new guidelines require drug makers to include a link on their drugs’ safety labels and outside packaging of the products that connects directly to a publicly accessible online repository with the drug’s most current instructions, including dosage recommendations, adverse events, and contraindications or drug interactions. The new ... Read More