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Combining old diabetes drug with new improves blood sugar control

Combining the commonly used metformin with another class of medication can greatly improve blood sugar control in Type 2 diabetics, according to new research. Metformin is in a class of drugs called biguanides. It works by decreasing the amount of glucose absorbed by food and the amount of glucose made by the liver. By doing this, it increases the body’s response to insulin. It is used alone or with other medications, including insulin, to treat type 2 diabetes. The new study, funded by drug maker Sanofi Aventis, tested metformin in combination with a drug in a new class of type ... Read More

Drug company testing type 2 diabetes drug designed to have fewer side effects

Drug developer BioKier currently testing a new oral formulation of type 2 diabetes treatment that may prove safer than injectable versions of the drug currently on the market. The new drug, called BKR-013, is designed to prompt the body to regulate blood sugar levels on its own. BioKier’s inspiration comes from gastric bypass surgery. Patients who have undergone this surgery have lost weight from eating less because their stomachs are smaller and they feel full faster. Doctors have also noted that some gastric bypass patients who were diabetic before surgery returned to normal blood sugar levels after surgery. In some ... Read More

Novel new diabetes treatment fares well in clinical trials

Clinical trials on a novel new type 2 diabetes treatment lowered glucose, did not increase lipids, and was well tolerated in patients with the chronic disease. The drug is an investigative liver-selective glucokinase activator, or GK activator, referred to as TTP399. It is a key regulator of glucose homeostasis. It is a member of the Hexokinase family and is expressed in the endocrine cells of the Langerhans islets of the liver, in the L- and K-cells of the intestines, and in the neurons of the central nervous system, in particular the hypothalamus. GK modulates blood glucose by inducing glucose-stimulated insulin ... Read More

Newborn head and body support products recalled due to presence of mold

Children’s Medical Ventures is recalling its Gel-E Donut and Squishon 2 products used in hospitals to support and cradle an infant’s head or body because of numerous complaints about visible mold on the outer surface of the products. The mold was determined to be Cladosporium and Penicillium Fungi, commonly found molds. Cladosporium can cause several different types of invasive infections including skin, eye, sinus and brain infections and those most vulnerable include newborns, critically ill patients, and patients with impaired or weakened immune systems. Both Cladosporium and Penicillium Fungi can cause difficulty breaking or allergic reaction. The recall is classified ... Read More

Young adults who were treated with growth hormones as children may be at greater risk for stroke

People who received growth hormones as children to treat short stature or hormone deficiency should be aware that they are at an increased risk of stroke caused by burst blood vessels when they become young adults, a team of French and British researchers say. The warning is based on findings from a study published in this week’s issue of the journal Neurology, and applies also to people who misuse the growth hormones to improve athletic performance, for body building and other “questionable reasons.” Growth hormones were approved in the United States in the mid-1980s to treat pituitary gland problems and to ... Read More

New sleeping pill gets FDA approval, awaits DEA clearance

A new type of prescription sleep aid has won approval from the Food and Drug Administration (FDA) and if given clearance from the Drug Enforcement Administration (DEA) should be commercially available later this year. Belsomra, made by Merck & Co., works by temporarily blocking chemicals in the brain that control sleep cycle and keep people awake at night. The sleeping pill is designed to help people with insomnia to sleep through the night. Belsomra was approved based on trials that pitted the medication against a placebo. It was not tested against other sleep aids, however, so it is not known ... Read More

Dialysis solutions recalled due to potential contamination

Baxter International is recalling two lots of Dianeal Low Calcium Peritoneal Dialysis Solution with 2.5 percent Dextrose 5000mL (Ambu-Flex II) because oxidized stainless steel, garment fiber and PVC particulate matter was present during the manufacturing process and seen floating in the solution. If the particulate within the solution is injected into patients it could cause local inflammation with foreign body reaction or result in adhesion formation. The matter could also potentially serve as a focal point for infection should any existing pre-existing peritonitis exist, which could be deadly to patients receiving the solution. The product labeling advises health care providers ... Read More

FDA provides guidance to help medical device manufacturers gain faster marketing approval

The Food and Drug Administration (FDA) is providing manufacturers with information to help them win faster approval for medical devices deemed “substantially equivalent” to other devices, even if the technology of the new device is different or carries different risks. The guidance is designed to prevent defective medical devices from passing through the agency’s abbreviated 510(k) approval process, which allows faster clearance to moderate risk devices if they are similar to other devices currently on the market. The FDA has been revamping the 510(k) process since it was revealed four years ago that the faulty Johnson & Johnson DePuy ASR ... Read More

RegenESlim appetite control capsules recalled due presence of dangerous ingredient

Certain lots of RegenESlim appetite control dietary supplements are being recalled because they contain an ingredient that may cause deadly side effects. A Food and Drug Administration (FDA) analysis found in two lots of RegenESlim the presence of DMAA, also known as 1,3-dimethylamylamine, methylhexanamine, or geranium extract, commonly used as a stimulant, pre-workout, and weight loss ingredient in supplements. The agency has warned that DMAA is potentially dangerous to health as it can narrow blood vessels and arteries, which can cause a rise in blood pressure or other cardiovascular problems such as shortness of breath, arrhythmias, tightening in the chest, ... Read More

Injectable skin and blood infection treatment recalled

Certain lots of the injectable drug Cubicin (daptomycin), used to treat skin infections and certain blood stream infections, are being recalled because of the potential presence of glass particles in vials. The administration of glass particulate, if present in an intravenous drug, poses a potential safety risk to patients such as thromboemobolism or a life-threatening pulmonary emboli. Other adverse events that could result from administration of glass particulate include phlebitis, mechanical block of the capillaries or arteries, activation of platelets, or subsequent generation of microthrombi. It can also cause the formation of granulomas, which can result in a protective local ... Read More